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Biomedical subjects

D B Saprygin

Publications and source records attributed to D B Saprygin.

At least 37 records · Page 2Linked to original sources
PubMed1984

[Is the damaging action of catecholamines on the myocardium realized via hyperstimulation of the beta receptors?].

Experiments on an isolated rat heart were made to compare the damaging action on the myocardium of catecholamines (noradrenaline, adrenaline and isoproterenol) differing in the affinity for beta-receptors. The damage to myocardial cells was evaluated from the release into the perfusate of intracellular enzymes (creatine phosphokinase and lactate dehydrogenase) and the number of contracture damaged myocytes. Noradrenaline exerted the most powerful damaging action on the myocardium at a concentration of 10(-6) M. Perfusion of the heart with isoproterenol at concentrations of 10(-6) M and 10(-5) M did not lead to the affection of cardiomyocytes. It was isoproterenol concentration exceeding noradrenaline concentration 100 times that produced an increase in the rate of the release of the enzymes to the perfusate and a rise of the number of contractures in the myocardium, with the above increase being less than that provoked by adrenaline and noradrenaline (10(-6) M). It is concluded that the mechanism of the cardiotoxic effect of catecholamines cannot be reduced only to their effect on myocardial beta-receptors.

Animals↗
PubMed1984

[Correlation between serum lipid level and coronary bed lesions in patients with ischemic heart disease].

The blood lipid levels were collated with the atherosclerotic damage to the coronary bed in 124 patients with coronary heart disease. An increase in the content of total cholesterol and low density lipoprotein cholesterol directly correlated with the degree of the total lesion of the coronary bed. The concentrations of high density cholesterol and very low density cholesterol and the atherogenicity index showed no correlation with the severity of atherosclerotic changes in the coronary arteries. The level of triglycerides in these patients displayed a tendency to increase. In evaluating the severity of coronary heart disease, it is recommended to determine the levels of total cholesterol and low density lipoprotein cholesterol. Changes in the concentration of high density lipoprotein cholesterol are unreliable for assessing the degree of coronary atherosclerosis.

Adult↗
PubMed1983

[Sensitivity of creatine phosphokinase in early diagnosis of myocardial infarction and improvement of the test's specificity by determination of the rate of increase of enzyme activity].

The activity of serum enzymes: creatine phosphokinase (CPK), CPK isoenzyme MB and asparagine aminotransferase--was examined every 1-3 hours after the onset of a painful attack in 68 patients with "determined" (according to the 1979 WHO classification) myocardial infarction (DMI) and 32 patients with unstable angina pectoris. The activity of all three enzymes was increased in 100% of DMI cases. The rate of enzyme activity increment (delta E/delta T) calculated for the first 3-12 hours of the disease demonstrated that absolute delta E/delta T values for CPK were significantly higher than those for other enzymes. The CPK delta E/delta T was several times as high in DMI patients as it was in patients with unstable angina. Measurement of the rate of CPK activity increment over any 6-hour interval within the first day after the painful attack is suggested as a way of further improvement of the test specificity.

Adult↗
PubMed1982

[Diagnosis and quantitative evaluation of irreversible myocardial damage by the cumulative activity of creatine phosphokinase MB isoenzyme in heart surgery patients].

In 185 patients after different cardiosurgical operations a postoperative follow-up study (after 3 hours) of the activity of MB creatinephosphokinase (CPK) was carried out. The cumulative activity of MB CPK was calculated (Q MB CPK) according to a modified Shell-Sobel formula. Trends in the type of curve changes of activity MB CPK were established and used to isolate three discrete levels of Q MB CPK (zero , average and high). The high level of MB CPK over 14.0 Eq was found only in patients with the intraoperational myocardial infarction, which in 13 cases (92%) was confirmed at the autopsy. Among patients with the average of zero level of Q MB CPK no myocardial infarction was found at autopsy (15 patients). The level of Q MB CPK did not depend on the surgical traumatism of myocardium. Zero level of Q MB CPK was found in 76% of patients after resection of the aneurysm of the left ventricle, and in 54% after valvular prosthesis. Determination of MB CPK is a specific and sensitive method of diagnosis of intraoperational myocardial infarctions. This method can be used in any cardiosurgical procedures.

Angina Pectoris↗
PubMed1982

[Role of determination of creatine kinase isoenzyme MB in the diagnosis of myocardial lesions after surgery of the major vessels].

A considerable increase in CPK activity is usually noted after reconstructive surgery on thoracic and abdominal aorta and its branches (75 patients), MB-CPK activity being increased in 48.0% of the cases. Increased cumulative MB-CPK activity, pointing to the isoenzyme's withdrawal from the myocardium (3.2 to 5.6 Eq), was established in 8 patients. It was only in one case (1.3%) that a typical curve and a high cumulative activity of the isoenzyme (29.14 Eq) suggested the diagnosis of acute myocardial infarction. Therefore, increased MB-CPK activity alone cannot signal focal myocardial necrosis. Although the increase in cumulative MB-CPK activity correlates, to some degree, with negative ECG developments in the patients with basic coronary disease, it is only the typical curve and high MB-CPK activity that can be used as specific criteria in the enzymatic diagnosis of myocardial infarction after reconstructive surgery on main vessels.

Adult↗
PubMed1981

[Use of contrical with heparin in the acute period of myocardial infarct].

The use of the methods of multiple (35) precordial ECG leads and serial tests for the activity of creatine phosphokinase and its MB fraction allows quantitative assessment of the dimensions of the necrotic zones. In injection of contrykal with heparin the dimensions of the myocardial infarct decreased. In early injection of these agents, the clinical and electrocardiographic findings improved more rapidly and the infarction zone was smaller. Injection of contrykal with heparin arrested the anginose attack more rapidly, corrected the peripheral symptoms of circulatory insufficiency, normalized arterial pressure and relieved the congestive phenomena in the lungs within a shorter period of time. The combined use of these agents is a pathogenetically substantiated method for the treatment of patients in the acute period of myocardial infarction for the purpose of restricting the dimensions of the ischemic damage to the myocardium.

Acute Disease↗
PubMed1980

[Hemo- and lymphosorption in cardiogenic shock (an experimental study)].

The important role of toxemia in the pathogenesis of cadiogenic shock was demonstrated in 38 experiments on dogs. It was found that the blood becomes toxic later than the lymph. Lymphosorption arrests the progress of toxemia but does not relieve it if it has already developed. The hemosorption method produced a good effect. Studies showed, however, that it does nor prevent the arrival of lymph with a high toxin content. The best effect was produced when lympho- and hemosorption were combined under conditions of stimulation of lymph production and lymph drainage.

Animals↗
PubMedDate not supplied

[The concentrations of somatotropic hormone and insulin in the blood of heart surgery patients with a complicated course of the postoperative period].

It has been shown that the course of the early postoperative period in cardiosurgical patients and its outcome is to a great extent related to adequate balance of adaptation hormones, whose levels and changes are determined by the functional state of compensatory-adaptive systems. Patients with favourable outcome of the complicated postoperative period along with synchronous activation of sympathoadrenal system (SAS), hypophyseoadrenal system (HAS) and an elevated somatotropic hormone (STH) level demonstrated adequately high blood insulin content, with the equilibrium in adrenalin/insulin and cortisol/insulin ratios retained, and moderate STH predominance over insulin. In 1/4 of patients with complicated postoperative period and unfavourable outcome an attenuated SAS response was accompanied by excessively high STH, ACTH, cortisol blood content and a lower insulin level, which determined relative insulin insufficiency.

Adolescent↗
PubMedDate not supplied

[The course of the early postoperative period in heart surgery patients in relation to the state of humoral regulatory mechanisms].

It has been shown that the course and outcome of the early postoperative period in cardiosurgical patients are to a great extent related to the functioning of the adaptation systems under study and their interrelations. An essential role of sympathoadrenal system (SAS) in the control over hormonal body status has been established. It ensures, provided its activity is retained, interaction of other hormonal systems as a uniform functional mechanism in postoperative stress. Decreased activity and intrasystemic coordination of SAS combined with low activity of renin-angiotensin-aldosterone system and excessively activated hypophyseal-adrenal system in patients with postoperative complications are indicative of adaptation mechanism damage and are of negative prognostic value.

Adolescent↗