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Biomedical subjects

D B Morgan

Publications and source records attributed to D B Morgan.

At least 109 records · Page 6Linked to original sources
PubMed1976

Hypophosphataemia: A complication of "innocuous dextrose-saline".

Plasma and urinary phosphate levels were studied before and after operation in 13 patients undergoing uncomplicated major surgery. The maintenance intravenous fluid in six patients was 0.9% saline and in the other seven patients it was 4% dextrose with 0.18% saline. Although the plasma-phosphate fell in both groups, reaching minimum on the second postoperative day and then returning towards normal, it was significantly lower in the group receiving dextrose on the second, third, and fourth postoperative days when the levels were below the normal range. It is suggested that when dextrose-saline solutions are indicated in postoperative patients the addition of phosphate to the solution should be considered.

Creatinine↗
PubMed1976

Diurnal pattern of water and electrolyte excretion and body weight in idiopathic orthostatic hypotension. The effect of three treatments.

The diurnal pattern of water and solute excretion and body weight were examined in five control subjects and in a patient with idiopathic orthostatic hypotension before and during treatment. The patient had a reversed diurnal pattern of excretion of sodium, urea and water but not of potassium and creatinine, and there was an excessive diurnal variation in body weight. The effects of three treatments, high salt diet alone and then with the addition of head-up tilt, and later fludrocortisone, were studied. Fludrocortisone caused marked clinical improvement and retention of sodium and water. Once a steady state was achieved none of the treatments had any significant effect either on the diurnal variation in weight or on the water and solute xcretion pattern except for a small reduction in sodium excretion at night when the patient slept with a head-up tilt. In is concluded that these treatments cause symptomatic improvement in idiopathic orthostatic hypotension through an increase in extracellular fluid volume rather than through any change in the abnormal diurnal pattern of water and salt excretion.

Aged↗
PubMed1975

Effects of a diphophonate on calcium metabolism in calcium-deprived rats.

Calcium metabolism was studied in growing rats, submitted to calcium deprivation ofvarious intensity. A decreased intake resulted in decreased net absorption of calcium(V'na), no change in bone formation (V'o+), and an increase in bone resorption (V'o -). In animals given dichloromethylene disphosphate (Cl'2MDP), a compoundknown to inhibit bone resorption, V'o+ was less than in the controls but again the same at all calcium intakes; V'na was below V'o+, V'o- still increased as the calcium intake was reduced. The various kinetic parameters in rats receiving Cl'2MDPwere indistinguishable from published data in parathyroidectomized (PTX) animals, yetblood calcium was low in PTX rats but normal in Cl'2MDP-atreated rats. It appears that the rat has an efficient mechanism for increasing bone resorption which is not inhibited by Cl'2MDP and does not require parathyroid hormone.

Animals↗
PubMed1974

The uptake and metabolism of (32-P)pyrophosphate by mouse calvaria in vitro.

In order to study the uptake and metabolism of PP(i) by bone, (32)PP(i) was added to the medium surrounding explanted mouse calvaria maintained in organ culture. Most of the PP(i) was hydrolysed during incubation, but there was a measurable entry of intact PP(i) into bone. When (32)P(i) was added to the medium, synthesis of PP(i) and organic phosphates from P(i) was observed in bone. There was no detectable passage of PP(i) from bone into the medium. These results are discussed in terms of two models of pyrophosphate hydrolysis and exchange. Some quantitative estimates about the fate of PP(i) in bone were made.

Animals↗