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Biomedical subjects

D B Martin

Publications and source records attributed to D B Martin.

59 records · Page 4Linked to original sources
PubMedDate not supplied

Beta hemolytic streptococcal endocarditis: predominance of non-group A organisms.

Identification of beta hemolytic streptococci (BHS) as group A or non-group A on the basis of bacitracin sensitivity rather than Lancefield serogrouping may lead to misidentification of the pathogen. In four recent cases of endocarditis due to BHS, the pathogens initially were identified as group A; Lancefield serogrouping showed all four to be group G. All four patients presented with a syndrome characteristic of acute bacterial endocarditis. Review of all cases of endocarditis at our institution for the past five years showed none due to group A BHS. In 166 previously reported cases of endocarditis due to BHS, 68 pathogens were serogrouped: 53 belonged to groups B, C, G, or H; only five were group A. Our four cases and review of the literature demonstrate the need for Lancefield serogrouping in serious beta hemolytic streptococcal infections, rather than reliance on bacitracin sensitivity.

Acute Disease↗
PubMedDate not supplied

Glycolytic inhibition by 2-deoxyglucose reduces hyperglycemia-associated mortality and morbidity in the ischemic rat.

Numerous laboratories have shown that hyperglycemia increases cerebral ischemic damage. This presumably results from increased lactate production and accumulation during ischemia. Although increased tissue lactic acidosis is associated with increased ischemic brain damage, this damage has not been directly linked to glycolytic flux. Because 2-deoxyglucose (2-DG) is a competitive inhibitor of glycolysis we tested its ability to reduce hyperglycemia-exacerbated ischemic brain damage. Severe forebrain ischemia was produced by the four-vessel occlusion model in rats. Four rats received 3 g/kg glucose and saline while a second group (n = 5) was injected with 3 g/kg glucose plus 1.6 g/kg 2-DG. A third group (n = 5) was treated with 1 g/kg glucose plus saline and a fourth group (n = 5) received 1 g/kg glucose and 1.6 g/kg 2-DG. All rats were injected i.p. 10 minutes prior to the ischemic insult with the same volume/kg body weight. All rats receiving the high dose of glucose alone (3 g/kg) were dead within 24 hours postischemia. Rats who received 2-DG in addition to 3 g/kg glucose showed only 40% mortality (p = 0.119 Fisher's Exact). 2-DG completely eliminated convulsions during the initial two hours of recovery which was significant (p = 0.008), however, all rats in both groups showed some convulsions by 24 hours postischemia. Among rats receiving the low glucose dose (1 g/kg), none of the rats receiving 2-DG died or convulsed by 24 hours postischemia.(ABSTRACT TRUNCATED AT 250 WORDS)

3-Hydroxybutyric Acid↗
PubMedDate not supplied

Nesidioblastosis associated with insulin-mediated hypoglycemia in an adult.

Nesidioblastosis, the process of differentiation of pancreatic islets from ductular epithelium, is a well-described cause of insulin-mediated hypoglycemia in neonates and infants, but not in adults. A 58-yr-old woman with characteristic clinical features of fasting hypoglycemia had inappropriately elevated plasma immunoreactive insulin levels during symptomatic episodes of fasting hypoglycemia. Angiography, palpation at laparotomy, and resection of the distal three-quarters of the pancreas provided no evidence of a tumor. Pathologic examination of the resected pancreas revealed the findings of nesidioblastosis, i.e., budding of islets from the wall of ductules, and also increased number and size of islets and abnormal shape and location of islets. An entire spectrum of islet cell abnormalities including nesidioblastosis can cause insulin-mediated hypoglycemia in adults, as it does in neonates and infants.

Adenoma, Islet Cell↗
PubMedDate not supplied

Organochlorine pesticides and polychlorinated biphenyls in sediment and fish from Wetlands in the north central United States.

Sediment samples collected in 1980-1982 from riverine and pothole wetlands at 17 locations in the north central United States were analyzed for organochlorine pesticides, certain of their metabolites, and polychlorinated biphenyls (PCBs). Concentrations were above minimum detection levels (5 ng/g of organochlorines and 20 ng/g of PCBs) in less than 4% of the samples taken. Fish samples taken at 9 of these 17 locations, and analyzed for the same compounds, showed a higher frequency of detectable contaminants. The most common compound found in fish was DDE, which was found in 51% of the samples at levels up to 512 ng/g. alpha-BHC was present at concentrations of 5 to 27 ng/g in 36% of the fish samples, and DDD was found at levels of 5 to 60 ng/g in 14%. Four other compounds, DDT, dieldrin, PCB, and trans-nonachlor, were detected in fish at relatively low concentrations in less than 10% of the samples. This survey, thus, indicated little contamination by organochlorine pesticides or PCBs in the wetland habitats of this region.

Animals↗