Biomedical subjects

D B Jarrett

Publications and source records attributed to D B Jarrett.

56 records · Page 4Linked to original sources

PubMedDate not supplied

Analysis of time to stabilization in the treatment of depression: biological and clinical correlates.

The discovery of clinical and biological variables which correlate with the rate of treatment response is an important aim of outcome research. In this report, such items were assessed in a large group of patients with recurrent depression to determine what variables contribute to stabilization during treatment. Relatively few items were strongly related to time to stabilization aside from age, clinical severity of illness, and number of previous episodes. One biological variable, cortisol nadir, was positively related to the time of stabilization. Similar assessments of non-responders did not yield any specific predictors.

Adult↗

PubMedDate not supplied

Sleep-related hormone secretion in depressed patients.

Among human subjects, sleep is a time of considerable neuro-endocrine activity and the nocturnal secretion of growth hormone is intimately related to the sleep-wake cycle. In contrast, the hypothalamic-pituitary-adrenal axis of entrained individuals shows a circadian pattern of activity with secretion increasing in the latter part of sleep. A variety of neuroendocrine disturbances have been described in depressed patients who also manifest consistent disturbances in their sleep-wake cycle. The sleep-wake cycle is capable of masking these rhythms and thereby modifying patterns of hormone secretion. The sleep disturbance in depressed patients appears to have little effect on the phase of either cortisol or growth hormone secretion but does reduce their amplitudes.

Adrenal Cortex↗