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Biomedical subjects

D B Horn

Publications and source records attributed to D B Horn.

At least 37 records · Page 2Linked to original sources
PubMed1976

Plasma renin activity in diabetic autonomic neuropathy.

Postural changes in plasma renin activity were studied in three groups of age and duration-matched male diabetics (potent, impotent and with postural hypotension) and in non-diabetic control subjects. Those diabetic subjects with postural hypotension due to automatic neuropathy had no increase in plasma renin activity to the erect posture whereas both the potent and impotent groups had similar plasma renin activity responses to the control subjects. There was a significant inverse correlation between the rise in plasma renin activity on standing and the postural drop in blood pressure (r = 0.476, P less than 0.01) but no correlation with other tests of autonomic reflex function such as the Valsalva manoeuvre and blood pressure response to sustained handgrip. The results suggested that the lesion responsible for the postural hypotension is in the efferent sympathetic pathway. However, neuropathy per se did not wholly explain the decreased postural plasma renin activity response. Diabetic nephropathy, with involvement of cells of juxtaglomerular apparatus, may also be implicated.

Adult↗
PubMed1974

Treatment of Paget's disease of bone with synthetic salmon calcitonin.

Thirteen patients with painful Paget's disease of bone were treated as outpatients with low doses of synthetic salmon calcitonin 22.5-50 mug three times weekly. Treatment produced full remission of pain in a mean time of 5.5 weeks and a mean depression of serum alkaline phosphatase activity of 33%.The interval before symptomatic relief could not be predicted from the variables studied. The ultimate fall in serum alkaline phosphatase activity, however, could be predicted from the initial levels and from the early rate of decrease (P < 0.001). Biochemical resistance to treatment, which occurred in three cases, could be related to the dose and duration of treatment.Prolonged remissions of pain may occur which are not related to biochemical remission, to the dose of calcitonin, or to the duration of treatment. The side effects attributable to salmon calcitonin were transient nausea (in nine patients), transient flushing (in four), diarrhoea (in two), and rash (in one) though in only one patient did treatment have to be withdrawn prematurely because of these effects.

Aged↗
PubMed1973

Bile acids in the diarrhoea of ileal resection.

Twenty individual diarrhoeal stools from three patients with ileal resection were centrifuged at 14 000 g for one hour at 10 degrees C to separate the stool into pellet and supernatant. Bile acids and electrolytes were measured in each phase. Relationships were examined between chenodeoxycholic acid and cholic acid in each phase and in toto to electrolyte and water loss. Chenodeoxycholic acid was associated with electrolyte and water loss whether present in solid or liquid phase. The association varied between individuals. The cholic acid content of the stool showed no association with electrolyte and water loss. It would appear that it is the total amount of chenodeoxycholic acid entering the colon, irrespective of its physical state, that is important in the diarrhoea of ileal dysfunction.

Adult↗