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Biomedical subjects

D B Crane

Publications and source records attributed to D B Crane.

10 recordsLinked to original sources

A re-appraisal of treatment in chronic bacterial prostatitis.

The pH of normal human expressed prostatic secretion in 136 samples from 93 men was 7.28 +/- 0.04. In 41 samples from 14 patients with documented chronic bacterial prostatitis the alkalinity of prostatic fluid was increased 10-fold (1 pH unit) and was 8.32 +/- 0.07. We believe these studies account for the failure of trimethoprim to eradicate human bacterial prostatitis effectively despite the experimental data documenting diffusion and concentration of trimethoprim in the acidic prostatic fluid of the normal dog. The factors governing drug diffusion into the prostate and the influence of pH on the concentration of trimethoprim in the expressed prostatic secretion are discussed.

Adult

Single stage urethroplasty as treatment for stricture disease.

The use of a full thickness free skin graft for a single stage urethroplasty in stricture disease has been popularized recently by Devine and Horton. From 1973 to 1977, 40 patients at our hospitals have been treated with single stage urethroplasty using this technique. Excellent results have been noted on followup evaluation.

Adolescent

Paraganglioma of urinary bladder wall.

A classic case of pheochromocytoma of the urinary bladder is presented. The history of headaches and palpitations during micturition is the result of sudden release of catecholamines into the general circulation. The diagnosis using selective arteriography as well as the medical and surgical management are described.

Adult

Chyluria.

A twenty-four-year-old black female presented through the outpatient department complaining of "white urine". Pertinent history, physical examination, and diagnostic studies are reviewed with special emphasis on lymphangiography. The literature is reviewed particularly with regard to laterilization of the fistula, thoracic duct obstruction, and methods of therapy.

Adult

Pelvic lipomatosis: 5-year followup.

Followup of 5 cases presented in 1971 and report of 8 additional cases confirm the initial conclusions that pelvic lipomatosis is a benign but potentially progressive process leading to ureteral obstruction. Young black subjects are affected most commonly. More than 40 per cent of the patients have required permanent urinary diversion.

Adult

Angiography in pheochromocytoma of the urinary bladder. Report of a case.

A case of pheochromocytoma of the urinary bladder in a 20-year-old female is reported. This is the 36th reported case in the English language literature. The patient had classical symptoms of vesical pheochromocytoma with sudden onset of headache, palpitations, and blood pressure elevation during voiding. The provisional diagnosis was arrived at on clinical history, laboratory investigations, including the estimation of catecholamines and vanil mandelic acid (VMA). The diagnosis was confirmed and the tumor was exactly localized by means of angiography. The angiographic appearance of pheochromocytoma of the urinary bladder is not pathognomonic and is similar to that previously described for adrenal pheochromocytoma. Angiography is, with adequate precautions, a safe and useful procedure for ruling out synchronous adrenal or extra-adrenal tumors and for exact localization of the bladder tumor.

Adult

External sphincterotomy: its effect on erections.

External urethral sphincterotomy on 129 paraplegics had little effect on erections. In the 101 patients with post-injury erections only 2 had cessation of erectile capacity. Subjectively, 16 per cent had partial loss and 13 per cent had an increase. The remaining 69 per cent had no change. When the data were correlated with level and completeness of injury, age, time since injury, time since sphincterotomy, postoperative delayed hemorrhage and effect on leg and bladder spasms, no conclusions could be drawn concerning the etiology of altered erections.

Adult