Investigation of use of goal attainment scaling to evaluate individual progress of clients with severe and profound mental retardation.
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Adolescent↗
Biomedical subjects
D B Bailey
Publications and source records attributed to D B Bailey.
Nuclear morphologic and morphometric analyses of nodular poorly differentiated lymphocytic lymphoma: assessment of small cleaved nuclei.
Comparative analytic measurements of nuclear parameters in normal and neoplastic lymphocytes are limited. In the present morphometric study lymphocyte nuclear features in 21 cases of nodular poorly differentiated lymphocytic lymphoma (NPDLL) were assessed with respect to the theoretical aspects of some non-Hodgkin's lymphoma (NHL) classifications. The mean nuclear area of the lymphocytes in NPDLL is generally within the range of the areas of unstimulated (mature) lymphocytes of mantle and follicular regions of lymph nodes with reactive hyperplasia. On this basis, the neoplastic lymphocytes in NPDLL do not reflect, at least cytologically, the antigen-activated, transforming lymphocytes of normal follicular centers. All measured nuclear parameters of small, unstimulated lymphocytes of neoplastic follicles suggest that major proportions of this component are also part of the neoplastic cohort. Sectional nuclear profiles in NPDLL are much more irregular in shape and have a higher percentage of invaginations than normal lymphocytes. However, only 4 to 5 per cent of nuclear profiles in NPDLL are of sufficient depth to be termed clefted. Serial section reconstruction of both normal and neoplastic lymphocytes indicates the degree to which the numbers of invaginated or clefted nuclei are underestimated in the examination of histologic sections. For example, the 4 to 5 per cent of nuclear profiles with clefts in histologic sections of NPDLL actually represent about 25 to 30 per cent of the lymphocyte population. On the basis of computer modeling of stylized nuclei with simple invaginations of varying depths and serial section reconstruction of normal and neoplastic nuclei, it is likely that all lymphocyte nuclei have some form of nuclear membrane invagination and that in poorly differentiated lymphomas these invaginations may be single and multiple discrete indentations or linear, branching grooves. Assessment of the ratio of nuclear invagination depth to nuclear diameter in normal and neoplastic lymphocytes indicates that transforming normal lymphocytes in follicular centers do not undergo a phase of increased nuclear clefting and that this ratio is somewhat greater in lymphocytes in NPDLL than in follicular center lymphocytes. However, the latter effect is not due to increased depth of nuclear invaginations in NPDLL, but rather results from the fact that mean nuclear diameter in this subtype of NHL is considerably smaller than that of normal lymphocytes.(ABSTRACT TRUNCATED AT 400 WORDS)
B-Lymphocytes↗
Participation of professionals, paraprofessionals, and direct-care staff members in the interdisciplinary team meeting.
Results of a study of individual participation in interdisciplinary team meetings, with a focus on the participation behavior of professionals, paraprofessionals, and direct-care staff members, were reported. Several differences in observed and self-perceived participation were noted, with the general finding that professional staff members exhibited the highest levels of participation, whereas direct-care staff members exhibited the lowest levels of participation.
Female↗
A triaxial model of the interdisciplinary team and group process.
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Child↗
Effects of lines of progress and semilogarithmic charts on ratings of charted data.
The extent to which interrater agreement and ratings of significance on both changes in level and trend are affected by lines of progress and semilogarithmic charts was investigated. Thirteen graduate students rated four sets of charts, each set containing 19 phase changes. Set I data were plotted on equal interval charts. In Set II a line of progress was drawn through each phase on each chart. In Set III data points were replotted on semilogarithmic charts. In Set IV a line of progress was drawn through each phase of each Set III chart. A significant main effect on interrater agreement was found for lines of progress as well as a significant 2-way interaction between lines of progress and change type. Three main effects (chart type, lines of progress, and type of change) and a significant 3-way interaction were found for ratings of significance. Implications of these data for visual analysis of charted data are discussed.
Journal Article↗
Measuring individual participation on the interdisciplinary team.
In this paper we describe a scale designed to measure individual participation in interdisciplinary team meetings. Data from an observational study of team meetings at a residential institution for severely and profoundly mentally retarded persons were used to examine the measurement characteristics of the scale. Acceptable levels of interobserver agreement were found. A principal components analysis demonstrated that participation is not a unitary construct, but consists of at least five relatively independent dimensions. A generalizability study indicated that participation varies across team meetings and suggested that at least two observations are needed to obtain an adequate picture of typical participation. A sample application of the scale was described, and implications of the scale for researchers and practitioners were discussed.
Hospitals, Psychiatric↗
Cadmium-113 nuclear magnetic resonance investigation of metal binding sites in concanavalin A.
Cadmium-113 nuclear magnetic resonance studies are presented on the 113Cd-substituted protein concanavalin A (Con A). This protein has two different conformations, locked and unlocked, as described previously by Brown et al. [Brown, R. D., III, Brewer, C. F., & Koenig, S. H. (1977) Biochemistry 16, 3883]. The unlocked form of Con A gives one 113Cd resonance, indicating rapid exchange of the metal ions between the solution and the binding sites. Solutions of the locked form show three resonances: a free cadmium resonance (68 ppm), a resonance assigned to 113 Cd occupying the manganese site (46 ppm), and a resonance assigned to 113Cd occupying the calcium site (--125 ppm). In addition, Pb(II) is shown to bind to the calcium site and Zn(II) is shown to have high affinity for both sites. Data have been presented in previous literature that support a model in which Con A binds monosaccharides in a different manner than it binds oligosaccharides. However, if this difference exists, it does not affect the metal binding sites. Also, some heterogeneity in Con A has been reported in the literature; however, we have shown that the presence of these heterogeneities does not affect the 113 Cd NMR parameters.
Binding Sites↗
Cadmium-113 nuclear magnetic resonance studies of cadmium-substituted derivatives of bovine superoxide dismutase.
We have prepared the following cadmium-113-substituted derivatives of bovine superoxide dismutase and recorded the nuclear magnetic resonance (NMR) spectrum of the cadmium: 2Cd(II), in which Cd(II) is presumed to bind to the Zn(II) site and the copper site is unoccupied, and 2Cd(II)--2Cu(I), which is analogous to the reduced form of the native protein. NMR transitions were observed at 310 ppm downfield from Cd(ClO4)2 for 2Cd(II) and at 320 ppm for the 2Cd(II)--2Cu(I)-containing proteins. In each case the observed line width was 27 +/- 2 Hz. The following conclusions were drawn. (a) The very small chemical-shift difference between the two derivatives indicates that the Cd(II) binding site is very similar in both samples. It follows from this result and previous work that the imidazolato bridge is protonated on the Cu side upon reduction of the Cu ion from the II to I valence state. (b) The extremely narrow line width of the resonance in both forms suggests a virtual identity of Cd(II) bound to both subunits of the molecule. (c) The relaxation time, T1 = 1.2 s, is caused by approximately equal contributions from chemical-shift anisotropy and dipolar interactions with nearby protons.
Animals↗
Professional skills, concerns, and perceived importance of work with families in early intervention.
Innovations brought about by Public Law 99-457 require early intervention personnel to expand their work practices to involve and support families in the provision of early intervention services. To support training needs in this area, and to understand possible barriers to change, this study examined the extent to which 142 early interventionists from two states felt competent in working with families, valued family roles, and were concerned about changing to family-centered practices. Relationships among these characteristics and experience, discipline, and job category were explored. In general, nurses and social workers scored higher than did educators and other health-care professionals on several dimensions of family-centered care. Many professionals expressed concerns about collaboration.
Persons with Disabilities↗
Phase I and pharmacokinetic evaluation of the combination of orally administered docetaxel and cyclosporin A in tumor-bearing cats.
Intravenously administered docetaxel (DT) is problematic in cats because of the requirement for premedication to ameliorate acute vehicle-induced hypersensitivity reactions. Previously we have revealed that therapeutic plasma concentrations of DT can be achieved in normal and tumor-bearing dogs when DT is administered PO in combination with oral cyclosporin A (CSA). The purpose of this study was to identify the maximally tolerated dosage and characterize the pharmacokinetic disposition of oral DT combined with CSA in cats with tumors. Eighteen tumor-bearing cats were enrolled in this phase I dose escalation and pharmacokinetic study. DT was administered by gavage with CSA (5 mg/kg) twice over a 3-week period. The starting dose of DT was 1.0 mg/kg. Based on the clinical toxicity profile, with gastrointestinal adverse effects and hematologic toxicity the maximal tolerated dose of oral DT was 1.75 mg/kg in combination with 5 mg/kg CSA. Additional studies are necessary to determine the efficacy of DT/CSA in cats with epithelial tumors.
Administration, Oral↗