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Biomedical subjects

D Autenrieth

Publications and source records attributed to D Autenrieth.

5 recordsLinked to original sources
PubMed1983

Synthesis, tissue distribution and tumor uptake of [99Tc]tetrasulfophthalocyanine.

99Tc-labeled-tetrasulfophthalocyanine was prepared by the condensing of sulfophthalic acid and pertechnetate in the presence of a reducing agent. Reaction products were purified in various chromatographic systems and characterized by combustion, specific activity and spectral analyses. The tissue distribution pattern of the major product was studied in tumor-bearing rats. Most of the activity accumulated in the liver, kidneys, ovaries and uterus, whereas tumor uptake mainly occurred in the exterior cell layers. The in vivo stability of the complex was evidenced by the absence of 99Tc accumulation in the thyroid and the stomach.

Adenocarcinoma↗
PubMed1978

Steroid-nucleosides.

A new class of potential chemotherapeutic agents consisting of steroids coupled with nucleoside bases is described. Such structures may be viewed as nucleosides in which the sugar moiety is replaced by a steroid molecule. We may therefore expect the nucleoside characteristics to give interference at the DNA level, resulting in the desired antitumor activity, whereas the steroid moiety may provide target specificity. A number of such coupling products were prepared and preliminary biologic studies are reported.

Animals↗