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Biomedical subjects

D Arvidsson

Publications and source records attributed to D Arvidsson.

At least 37 records · Page 2Linked to original sources
PubMed1998

Laparoscopic common bile duct exploration.

OBJECTIVE: To explore the feasibility of laparoscopic techniques for the removal of common bile duct (CBD) stones. DESIGN: Retrospective analysis. SETTING: University hospital, Sweden. SUBJECTS: 39 patients who underwent laparoscopic common bile duct exploration, either by a transcystic technique or by choledochotomy, between September 1992 and April 1995. INTERVENTIONS: Cholecystectomy, intraoperative cholangiography, and removal of CBD-stones by a transcystic technique (n=22), laparoscopic choledocholithotomy (n=11), or after conversion to open choledocholithotomy (n=6). MAIN OUTCOME MEASURES: Stone clearance rates, operative time, complications, and postoperative hospital stay. RESULTS: Stone removal was achieved in 32/39 patients (82%) by a laparoscopic approach. Reasons for failure were early in our experience, and the result of technical difficulties or stones that were too large for the transcystic approach, or with impacted stones at choledochotomy. Postoperative morbidity was low (n=4, 10%) with no mortality. CONCLUSIONS: Common bile duct stones can be removed in a large proportion of patients undergoing laparoscopic cholecystectomy, either by a laparoscopic transcystic technique or through a laparoscopic choledochotomy. The laparoscopic techniques need further evaluation, preferably in prospective multicentre trials comparing other treatment strategies including endoscopic sphincterotomy.

Adult↗
PubMed1998

A survey of surgical treatment of gallstone disease and the diffusion of laparoscopic surgery in Sweden 1992-93.

OBJECTIVE: To study the diffusion of laparoscopic biliary surgery in Sweden, 1992-93. DESIGN: A prospective survey of all biliary surgery for gallstone disease recorded for 8 weeks in 1992 and the same period in 1993. SETTING: All surgical departments in Sweden. SUBJECTS: A consecutive series of 1938 patients in 1992 and 1748 patients in 1993. MAIN OUTCOME MEASURES: The changing indications, diffusion, morbidity, mortality, postoperative and hospital stay after laparoscopic cholecystectomy (LC) in Sweden in 1992 compared with 1993. RESULTS: Despite the spread of LC, the indications did not change between 1992 and 1993 (p=0.31). The total number of cholecystectomies decreased from 1938 in 1992 to 1748 in 1993. The overall percentage of laparoscopic cholecystectomies (LCs) increased from 74.7% to 81.2% (p <0.001) between 1992 and 1993. Postoperative morbidity and mortality after LC did not differ between 1992 and 1993, but the total morbidity was 9.0% in 1992 and 7.0% in 1993 (p=0.02). Mortality for all cholecystectomies did not change over the periods, being 0.6% in 1992 and 0.2% in 1993 (p=0.07). The numbers of LCs done in any hospital were divided in two groups, 20 or fewer and 21-80. In the smaller group, the postoperative morbidity was 7.1% and in the larger group it was 7.0%, (p=0.9). The postoperative mortality was 0.1% in both groups. The postoperative and total hospital stays of all cholecystectomies decreased from 3.4 days in 1992 to 2.9 days in 1993 (p=0.001) and from 5.0 in 1992 to 4.4 days in 1993 (p < 0.001), respectively. The postoperative and total hospital stays of LCs decreased from 2.0 in 1992 to 1.8 days in 1993 (p=0.009) and from 3.3 in 1992 to 2.9 days in 1993 (p=0.007), respectively. CONCLUSION: Despite the introduction and diffusion of the new technology, LC, the indications for surgery did not change and the number of cholecystectomies did not increase from 1992 to 1993. The morbidity and mortality of LC and the mortality of all cholecystectomies were unchanged between 1992 and 1993, but the morbidity for all cholecystectomies decreased. The number of LC or all cholecystectomies done in any particular hospital were not related to morbidity or to mortality.

Cholecystectomy, Laparoscopic↗
PubMed1997

[Laparoscopy possible even in cholelithiasis. Results for 96 patients from three different hospitals are reviewed].

At laparoscopic cholecystectomy, a procedure routinely used at Swedish surgery departments today, common bile duct stones are found to be present in 5-10 per cent of cases. During recent years, several alternative procedures have been evolved for the management of duct stones, such as operative or postoperative endoscopic sphincterolomy, or conversion to open surgery and choledochotomy. The article gives an account of laparoscopic treatment of common bile duct stones, and results obtained in 96 patients from three surgery departments in Sweden. Three different primary techniques were used: saline flushing via the cholangiography catheter, after intravenous injection of 1 mg of glucagon (in six cases of small stones); transcystic common duct exploration (TCDE), with cholodochoscopy and a Dermia basket (68 cases); and laparoscopic choledochotomy and choledochoscopy (22 cases). The success rate was 88 per cent (84/96), and mortality zero. In many cases the postoperative course was similar to that of patients undergoing laparoscopic cholecystectomy alone. We recommend TCDE in cases of common bile duct stones of no more than 8-9 mm in diameter, and where the cystic duct is large. Single-stage laparoscopic treatment of bile duct stones seems to be a safe and effective method of dealing with two problems in the same setting, and is an important alternative in the management of duct stones.

Adult↗
PubMed1997

Population-based study of cancer risk and relative survival following sphincterotomy for stones in the common bile duct.

BACKGROUND: Endoscopic sphincterotomy was introduced in 1974 as a procedure for removing stones in the common bile duct. To assess the long-term risk of cancer and relative survival, all patients who underwent this procedure at six different hospitals between 1977 and 1985 were identified. METHODS: A total of 992 patients was identified and they were followed by linkage to the Swedish Death Registry and the Swedish Cancer Registry. RESULTS: At 1 year or more after sphincterotomy there was no increased risk of cancer in the liver, gallbladder, bile duct or pancreas (standardized incidence ratio 0.80, 95 per cent confidence interval 0.3-1.9). Relative survival was lowered slightly in the first year after sphincterotomy, but did not differ from that of the background population thereafter. CONCLUSION: Endoscopic sphincterotomy for stones in the common bile duct does not appear to affect the risk of cancer in the pancreas, liver or bile ducts, nor does it affect long-term survival.

Adult↗
PubMed1996

A cost-minimization analysis of laparoscopic cholecystectomy versus open cholecystectomy.

BACKGROUND: Earlier economic analyses have evaluated charges but not costs, and have not considered the cost of production losses associated with open and laparoscopic cholecystectomy. This study attempted to accomplish an economic evaluation of open versus laparoscopic cholecystectomy from the point of view of society. METHODS: A cost-minimization analysis, using a clinical decision model, was performed. The data used were taken from different clinical studies, Swedish national registers, local patient statistics, and hospital accounting systems. The direct and indirect costs were measured. RESULTS: Laparoscopic cholecystectomy resulted in cost savings per patient amounting to about 2,400 SEK (as of 31 August 1994, Pound = 11.90 SEK; $1 = 7.76 SEK) compared with open surgery. CONCLUSIONS: From the point of view of society, laparoscopic cholecystectomy was a cost-saving strategy if at least 68 patients were operated on yearly. However, with regard to hospital costs, open cholecystectomy was less expensive than laparoscopic cholecystectomy.

Cholecystectomy↗
PubMed1995

Laparoscopic suture rectopexy.

PURPOSE: This article describes a technique for laparoscopic suture rectopexy and assesses the postoperative results. METHODS: The rectum was fixed to the presacral fascia with five to six sutures. The procedure was performed using a laparoscope in four patients. RESULTS: There were no postoperative complications. In one patient a large enterocele was observed during the operation. This patient developed a recurrence about one month postoperatively. CONCLUSION: Laparoscopic suture rectopexy might be an alternative to open rectopexy for patients with isolated rectal prolapse.

Adult↗
PubMed1995

Hepatic extraction of hyaluronic acid in porcine peritonitis.

The hepatic extraction of hyaluronic acid (HA) was studied in porcine fecal peritonitis in two groups of animals given various amounts of volume substitution. There was a progressive decrease in hepatic blood flow (QH) and a corresponding increase in the plasma concentration of HA in arterial blood over a 5-hour observation period, less pronounced in animals given more volume substitution. While hepatic clearance of HA decreased, the extraction ratio over the liver was not altered. The extracted amount of HA, which at steady state reflects the turnover of HA, was also unchanged. There was a significant correlation between QH and arterial HA concentration (r = 0.57; p < 0.05). The data suggest that the arterial HA concentration in sepsis reflects QH rather than an altered ability of the liver to eliminate HA.

Animals↗
PubMed1995

Effects of pneumoperitoneum on splanchnic hemodynamics: an experimental study in pigs.

OBJECTIVE: To study the effects on splanchnic haemodynamics of pneumoperitoneum induced by carbon dioxide insufflation. DESIGN: Controlled experimental study. ANIMALS: 11 Pigs weighing 19-30 kg. INTERVENTION: The animals were divided into a control group (n = 4) and a experimental group (n = 7). Experimental animals were subjected to stepwise increasing intra-abdominal pressure from 0 mm Hg to 25 mm Hg by carbon dioxide insufflation. MAIN OUTCOME MEASURES: Portal venous blood flow, portal venous blood pressure, portal/hepatic vascular resistance, and gastrointestinal vascular resistance. RESULTS: At 25 mm Hg portal venous blood flow was reduced (66% of baseline), and portal venous blood pressure and portal/hepatic vascular resistance were increased (360% and 650% of baseline, respectively). The increase in gastrointestinal vascular resistance was less pronounced. CONCLUSIONS: Increased intra-abdominal pressure caused significant changes in the splanchnic haemodynamics. The risk was greater if the intra-abdominal pressure exceeded 15 mm Hg.

Animals↗
PubMed1994

Laparoscopic versus open cholecystectomy: hospitalization, sick leave, analgesia and trauma responses.

Laparoscopic cholecystectomy has rapidly become established as the treatment of choice for cholecystolithiasis. There is very little evidence, however, to support the claimed benefit to patients. In the present study 30 consecutive patients below the age of 65 years without acute cholecystitis and with no signs of common bile duct stones were randomized to laparoscopic or conventional open cholecystectomy. Median (interquartile range) intravenous consumption of pethidine with a patient-controlled injection device between 13 and 24 h after surgery was 125 (62-175) mg in patients who underwent the laparoscopic procedure and 200 (150-250) mg in those who had open operation. Urinary adrenaline and cortisol levels as well as those of plasma glucose, C-reactive protein and interleukin 6 were increased after surgery in both groups of patients, but without any significant difference between them. The mean(s.d.) duration of postoperative hospital stay (2.8(0.8) versus 1.8(0.6) days) and sick leave (24.0(4.4) versus 11.7(4.1) days) was significantly longer with open than laparoscopic cholecystectomy. The findings demonstrate obvious advantages of laparoscopic surgery as regards postoperative pain and convalescence, although factors reflecting the magnitude of trauma did not differ.

Absenteeism↗
PubMed1994

Ultrasound monitored laser-induced local hyperthermia in the liver. An experimental study on pigs.

Ultrasound (US) was used to monitor the size of tissue necrosis generated by Nd-YAG laser-induced local interstitial hyperthermia and tissue coagulation in 8 normal pig livers. Four treatments were done in each liver with 4 different energy settings. The size of the tissue necrosis measured on specimens was compared to the size measured on US. The laser energy caused a round tissue necrosis with some charring in the centre surrounded by a zone of white necrosis and a thin border of hyperaemia. A good correlation was found between the true and US-measured size of the necrosis diameters. It therefore seems possible to safely guide and monitor local laser hyperthermia in the liver with real-time US. The water-cooled quartz fibre used in this study has, however, some limitations.

Aluminum Oxide↗
PubMed1993

Inhibition of CD18-dependent adherence of polymorphonuclear leukocytes does not affect liver oxygen consumption in fecal peritonitis in pigs.

We tested the hypothesis that circulating polymorphonuclear leukocytes (PMNs), adhering to endothelium of the liver vascular bed are involved in the alterations of the liver oxygen delivery (DO2) and consumption (VO2) that is a result of fecal peritonitis in pigs. Twenty-two pigs were divided into three groups. Animals in group I (n = 7) served as controls. Fecal peritonitis was induced in groups II (n = 7) and III (n = 8). Animals in group III were pretreated with IB4, a monoclonal anti-CD18 antibody inhibiting adherence of PMNs to the endothelium. Peritonitis increased liver VO2 in groups II and III in spite of decreased liver DO2. In group I, circulating PMNs increased during the experimental period. Sepsis caused a decrease in the number of circulating PMNs in group II, an effect that was fully counteracted in group III, where the number of PMNs rose to control level. Myeloperoxidase activity and morphometric determination of PMN infiltration in liver biopsies virtually paralleled the circulating PMN count. Although fecal peritonitis is followed by a CD18-dependent leukopenia that can be counteracted by pretreatment with an anti-CD18 antibodies, this treatment does not affect the alteration in liver VO2 and DO2 observed.

Animals↗
PubMed1993

[Laparoscopic surgery. A shift in paradigm?].

Since it was first introduced at the beginning of the century, laparoscopy has been developed by pioneers in the field of gynaecological surgery from a diagnostic aid to a high tech tool for use in various branches of surgery. In the near future, this rapidly developing technique, with three-dimensional video and robot-assisted surgery, will require well planned theoretical and practical training.

Abdominal Injuries↗