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Biomedical subjects

D Antoniadis

Publications and source records attributed to D Antoniadis.

11 recordsLinked to original sources
PubMed2005

The controversial role of serum uric acid in essential hypertension: relationships with indices of target organ damage.

The role of serum uric acid (SUA) in the context of adverse cardiovascular events in hypertensive subjects is controversial. Additionally, the relationship between SUA and indices of target organ damage is not well defined in this setting. Towards this end, we studied 842 consecutive nondiabetic patients with stage I-II essential hypertension (office blood pressure=148/95 mmHg, aged 53.4 years), referred to our outpatient hypertensive unit within a period of 4 years. According to the urinary albumin excretion (UAE), the study population was classified into those with microalbuminuria [MA(+), UAE=20-200 mg/24 h, n=222] and those without MA [MA (-), UAE< 20 mg/24 h, n=620]. Moreover, according to the presence of left ventricular hypertrophy (LVH) the participants were subdivided into two additional groups: [LVH (+), n=305 and LVH (-), n=537]. SUA levels were higher by 0.4 mg/dl, (P=0.04) in group MA (+) compared with the group MA (-), while no difference was observed between groups LVH (+) and LVH (-) (P=NS). In the entire population, SUA was correlated with body mass index (BMI) (r=0.17, P<0.001), waist/hip ratio (r=0.3, P<0.001), office systolic blood pressure (SBP) (r=0.14, P<0.05), triglycerides levels (r=0.25, P<0.001), UAE (r=0.35, P<0.001) and HDL (r=-0.26, P<0.001). Multiple regression analysis demonstrated that SUA was significantly related with BMI, office SBP and UAE (P<0.05). In conclusion, increased SUA levels are associated with MA but not with LVH in essential hypertensive subjects. Whether these inter-relationships may elucidate the clinical positioning of augmented SUA in this setting remains to be clarified in future studies.

Albuminuria↗
PubMed2000

Absence of any significant effects of circadian blood pressure variations on carotid artery elastic properties in essential hypertensive subjects.

We sought in this study to examine the effects of diurnal blood pressure variations upon common carotid artery (CCA) elasticity in selected subjects with uncomplicated moderate essential hypertension. Towards this end, 174 non-smoker subjects with stage I-II essential hypertension and without diabetes mellitus, left ventricular hypertrophy and carotid atherosclerosis, were classified as dippers and non-dippers according to the diurnal variation of >10% between mean daytime and night-time systolic and diastolic blood pressure (BP) in 24-h non-invasive ambulatory BP monitoring. CCA distensibility was derived by a combination of surface ultrasonographic data and simultaneous BP measurements at the brachial artery. The dippers and non-dippers were similar with respect to demographic characteristics. Non-dippers had significantly greater office systolic BP, 24-h systolic BP and ambulatory pulse pressure (PP) and significantly less (daytime-night-time) systolic and diastolic BP fall (by 16 mm Hg and 11 mm Hg respectively, P< 0.0001) compared to dippers. CCA distensibility was significantly reduced in non-dippers compared to dippers (by 0.89 dyne(-1)/cm(2/)10(-6), P < 0.05). Multiple linear regression analysis identified patient age and ambulatory PP as significant predictors of the CCA elasticity index. When patient age, 24-h systolic and diastolic BP were used as covariates in an analysis of covariance, the difference of CCA elasticity between dippers and non-dippers ceased to reach statistical significance. In contrast, when patient age, ambulatory PP, systolic (daytime-night-time) BP fall and diastolic (daytime-night-time) BP fall were used as covariates, the difference of CCA distensibility between dippers and non-dippers continued to be statistically significant. In conclusion, the excessive impairment of CCA elastic properties in non-dippers compared to dippers hypertensive seems to be ascribed to the increased of total 24-h haemodynamic load and not to the circadian pattern of BP. Journal of Human Hypertension (2000) 14, 813-818

Adult↗
PubMed1996

Oral tuberculosis.

A case with oral tuberculosis and unaware of systemic tuberculosis is reported. The oral lesions clinically manifested as two painless ulcerations in the hard palate. Pulmonary tuberculosis was diagnosed following the histopathologic and bacteriologic examination of the oral lesions.

Aged↗
PubMed1990

[Ultrastructural and histochemical study of a pleomorphic adenoma of the palate].

Histochemical and ultrastructural study of the epithelial regions forming lumina in one case of pleomorphic adenoma of the palate was undertaken. The ultrastructural findings suggest that these epithelial regions are derived from the intercalated ducts. The presence in the cytoplasm of periluminal cells of pinocytotic vesicles and vacuoles containing material similar in appearance of that seen in the luminal supports a reabsorptive activity of these cells. The microcalculi of calcium phosphate occasionally seen in the cytoplasm of these cells may be formed by the phagocytosis of the endocytotic material from the lumina.

Adenoma, Pleomorphic↗
PubMed1990

[Treatment of sialolithiasis and its complications with intraglandular injection of biotherapeutic solution].

The creation of sialoliths in the ductal system of major salivary glands causes characteristic symptoms due to the obstruction of the flow of produced saliva. If sialolithiasis is not treated early obstructive sialadenitis will develop and its repeated relapses may lead to fibrosis and degeneration of glandular parenchyma. In this study we present the method of intraglandular injection of biotherapeutic solution (1.000.000 I.U. penicillin G in 5 cc normal saline) to achieve treatment of obstructive sialadenitis and rejection of the sialolith. Our results as shown in tables I and II and in figures 1-9 are very encouraging. From the conclusions drawn it looks like this method can be recommended as an optional solution to surgery (lithectomy-adenectomy) under the conditions mentioned in the discussion.

Humans↗
PubMed1989

[Histochemical study on the mucosubstances of the calculi of the main excretory duct of the human submandibular gland].

The consideration that mucosubstances act as sites of nucleation and salivary calculi growth prompted to this investigation. Nine calculi of the main excretory duct of the submandibular gland were decalcified and routinely embedded in paraffin. From the blocks serial sections were cut and stained with haematoxylin and eosin and the subsequent histochemical methods for mucosubstances. 1) Alcian Blue-PAS. 2) High Iron Diamine-Alcian Blue. 3) Alcian Blue with critical electrolyte concentration. 4) Alcian Blue before and after testicular hyaluronidase digestion. 5) Acrolein-Thionin-Shiff-PAS 6) Toluidine Blue. Neutral and acid glycoproteins originated from the submandibular gland were predominated in the organic matrix. Glycosaminoglycans probably originated from the connective tissue were detected in the outer areas of the organic matrix. In the central and peripheral parts of 3 salivary calculi spheroid bodies, 1-30 in diameter, were present. The spheroid bodies were unstained with all the histochemical methods for mucosubstances. It is possible the glycoproteins of the submandibular gland to act as nucleating sites in the formation of calculi or, to be passive constituents which are bound by the already formed crystals of the calculi.

Glycoproteins↗
PubMed1985

Studies on the vascular drainage system of the hamster buccal pouch.

Because some investigators feel that the hamster buccal pouch is an immune privileged site with no lymphatic drainage, this study was done to demonstrate and further elucidate a drainage system from the pouch to the cervical nodes. Eight hamsters were injected with india ink, submucosally in the right pouch. Dissections at one or 2 days revealed ink in macrophages in the right submandibular nodes at 2 days. Histologically, the ink was noted within macrophages which aggregated around blood vessels. No lymph vessels were noted in the pouch. Six hamsters were injected with fluorochrome-labelled latex microspheres. At 2 and at 4 days the microspheres were noted in both the pouches and the ipsilateral submandibular nodes. The results indicate there is a delayed lymphatic drainage from cheek pouches to the submandibular nodes mediated by macrophages.

Animals↗
PubMedDate not supplied

[Clinical study of sialolithiasis. Findings from 100 cases].

The present work is based on a study of 100 cases of sialolithiasis referred to the Department of Oral Medicine, Dental School, University of Thessaloniki during the period 1963-1986. Among 100 cases sialolithiasis was distributed as following: Submandibular glands 89 cases, parotids 8 cases and minor salivary glands 3 cases. Sialolithiasis of sublingual glands were not found. In most of the cases the calculus was single while on 16 cases calculi were double or even more. Among the cases of sialolithiasis of minor salivary glands we found single in two cases while in the remaining one the calculi were double. There was a slight but not significant prevalence in the male sex (52 male/48 female) and their age varied from 6 to 70 years. In 72% of the cases the patient's age was under 40 with the most common (34%) in the 3rd decade. Inflammatory swelling of the sublingual plica and wharton's duct appeared in 46.4%. Complication of acute sialadenitis was observed in 23.7% of the cases. The first symptom was swelling of the gland during the meals (88.7%) while pain in the gland was followed after different period of time. The duration of symptoms was ranged between 1 to 30 years in 3% of the cases, and in the remaining 61% it ranged from 1 day to 1 year. The calculi were removed surgically in 40 cases and conservatively in 8 cases. All three cases of minor salivary gland sialolithiasis were treated surgically. The remaining 49 patients didn't return for complete treatment.

Adolescent↗