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Biomedical subjects

D Andersen

Publications and source records attributed to D Andersen.

At least 109 records · Page 6Linked to original sources
PubMed1977

Parietal cell (highly selective or proximal gastric) vagotomy for peptic ulcer disease.

Parietal cell vagotomy has been in clinical use for 7 years in elective treatment of nonobstructive duodenal ulcer, and for even a shorter period for complicated cases and for gastric ulcer The evolution of the surgical technique has not yet come to an end and the ability to perform the procedure is still improving. It can therefore be questioned, if this operation is yet ripe for a realistic clinical trial, and the great variation in recurrence rate reported in pilot series as well as in prospective randomized clinical trials points to the possibility that we will have to wait several years before the anticipated mean recurrence rate is known. At present it can be stated that even if gastric emptying is not quite undisturbed, the addition of a drainage procedure in nonobstructive cases is unnecessary. The same may be true in some patients with pyloric obstruction. Furthermore, the mortality rate is very low and the incidence of moderate-to-severe dumping and diarrhea is virtually nil.

Animals↗
PubMed1977

Gastrin concentrations in serum and gastric mucosa in patients with pernicious anaemia.

Sessile polyps in the antrum were found in 12 of 51 patients with pernicious anaemia. During gastroscopy, mucosal biopsies for gastrin determination were taken from the antrum and fundus and from the polyps. Patients with high gastrin concentration in the antral mucosa showed high serum gastrin concentrations, while most patients with low antral gastrin concentrations also had low serum gastrin values. On an average, the gastrin concentrations in the antrum were approximately 10 times, and those in the fundus approximately 100 times, higher than the corresponding values obtained in a reference group. The gastrin content in the polyps was not different from that in the surrounding antral mucosa. This study suggests that the polyps are not due to a functional hypertrophy of the antral mucosa caused by locally increased production of gastrin.

Adult↗
PubMed1977

Malrotation of the duodenum. Frequency in a radiographic control group.

In a prospective radiographic study, abnormal configurations with kinking and torsion (malrotation) of the duodenum were found in 41% of 150 non-dyspeptic subjects. Malrotation of the duodenum (MD) was more frequent before the age of 30, and in the entire series the frequency decreased significantly with age from approximately 60% at 20 years to approximately 25% in individual aged 35 years or more. It should be considered whether the same radiographic configuration as in MD up to the age of 30--35 years is merely due to uncompleted disposition and fixation of the duodenum, so that the diagnosis of MD cannot be definitely established until after that age. In the presence of MD, the luminal diameter of the duodenum was larger than normal, and there was a greater tendency to gastric retention at 4 hours after the barium meal.

Adolescent↗
PubMed1977

Malrotation of the duodenum and duodenal ulcer.

In 173 patients with surgically confirmed duodenal ulcer, malrotation of the duodenum (MD) was found in the pre-operative radiographs in a total of 54% without significant differences in the age and sex distribution. As compared with a control group, the frequency of MD was significantly increased in men and in patients over 50 years (Table I). The luminal diameter in the presence of MD was larger in the ulcer patients than in the control group (Table II). Gastric retention at 6 hours after the barium meal was more frequent in ulcer patients with MD than in those with normal duodenal configuration, and in both groups more frequent than in the control group. At a follow-up examination at least 12 months after the operation for duodenal ulcer, a significant tendency to a poorer result was revealed in patients with MD, manifested by persistent or postoperatively developed postcibal pain, fullness, nausea and vomiting (Table III-V), except in patients who had undergone parietal-cell vagotomy without pyloroplasty. The latter observation suggests that, in the presence of MD, preserved pyloric function is of significance in the frequency of subsequent manifest symptoms of this anomaly.

Adolescent↗
PubMed1977

Colonic haustral pattern in relation to pressure activity and presence of diverticula.

The correlation between the haustral pattern in the sigmoid colon, on the one hand, and the pressure activity and presence of diverticula, on the other, was examined in 184 patients, subjected to both X-ray examination and sigmoid pressure measurement. No correlation was found between an increased haustral pattern and a high pressure activity. Only a special S-shaped haustral pattern showed a slight correlation to an increased pressure activity. An interpretation of colonic haustral pattern in terms of muscular activity, therefore, seems unwarranted. A significant correlation was found between an increased haustral pattern and the presence of sigmoid diverticula.

Colon↗
PubMed1977

Gastric mucosal polyps in pernicious anaemia.

In a 4-year follow-up study of 68 patients with pernicious anaemia gastric polyps were observed in 25 patients. In some patients the polyps seemed to vanish completely from one year to another, while they might ascen or increase in other patients. None of these polyps underwent malignanttransformation during thperiod f observation, and by histological examination they could be classified as non-neoplastic regenerative benign polyps in an atrophic gastric mucosa. In our opinion the surgical attitude to these nonneoplastic gastric polyps in pernicious anaemia should be restrictive.

Adult↗
PubMed1977

Peritoneal lavage in the diagnosis of intraperitoneal bleeding.

The ability of peritoneal lavage with normal saline to disclose intraperitoneal haemorrhage requiring surgical intervention was assessed in a prospektive study of 30 patients admitted after blunt abdominal trauma or on suspicioun of ruptured ectopic pregnancy. The results were compared with the results of a meticulous clinical examination including simple laboratory tests, and were found significantly more reliable in the management of these patients.

Adolescent↗
PubMed1976

Intraluminal pressure in the sigmoid colon. I. Method and results in normal subjects.

A modified method for measurement of pressure activity in the sigmoid colon is presented, using open-ended tubes and measurement of pressure activity for 30 minutes after intravenous administration of 0.5 mg of neostigmine. The motility index in 12 normal persons was found to have median 597 with a range of 125-1169. Variation among persons exceeded the day-to-day variation significantly. Error in reading the curves was negligible.

Adult↗
PubMed1976

Intraluminal pressure in the sigmoid colon. II. Patients with sigmoid diverticula and related conditions.

Patients with lower abdominal symptoms, indicating colonic disorder, were classified into predefined clinical syndromes. Two important syndromes were colicky sigmoid syndrome and chronic diverticular disease. The first one, characterized by presence of colicky lower abdominal pains but absence of colonic diverticula, probably covers what is generally referred to as 'irritable bowel syndrome'. The second one was characterized by presence of lower abdominal colics and of colonic diverticula. The results showed a significant correlation between the presence of lower abdominal colics and a high pressure activity in the sigmoid colon after intravenous neostigmine. There was, however, no correlation between the presence of diverticula and a high pressure activity. The generally accepted theory of a high pressure activity as the dominant factor in the pathogenesis of colonic diverticula, therefore, was questioned, as was the equally accepted theory of a gradual development of chronic diverticular disease from the adiverticular colicky sigmoid syndrome.

Adult↗