Search PubMed⌕ Search

Biomedical subjects

D Albert

Publications and source records attributed to D Albert.

At least 109 records · Page 6Linked to original sources
PubMed1980

Halo nevi and the Vogt-Koyanagi-Harada syndrome. Manifestations of vitiligo.

A 10-year-old boy with Vogt-Koyanagi-Harada syndrome had loss of pigment cells in the skin, the halo nevi, the retina, and probably the leptomeninges. The amount of inflammation that accompanied destruction of pigment cells varied greatly and seemed to determine whether the patient had symptoms from his vitiligo. This patient exhibited symptoms associated with loss of pigment cells in his skin and leptomeninges, but not from the destruction of the pigment cells in his eyes. We suggest that vitiligo is a disease that can be manifested in any tissue containing pigment cells and has a variable clinical expression.

Child↗
PubMed1979

Interstitial deletion of chromosome 13 and associated congenital anomalies.

An interstitial deletion of chromosome 13 with breakpoints at 13q22 and 13q32 is presented. The clinical findings associated with this deletion are discussed in relation to the correlations of specific chromosomal bands with constellations of congenital defects as described by Niebuhr and Ottosen (1973), Niebuhr (1977). Lewandowski and Yunis (1975), and Noel et al. (1976).

Abnormalities, Multiple↗
PubMedDate not supplied

Psychopharmacologic treatment of negative schizophrenic symptoms.

Diverse pharmacologic agents have been reported to be effective in treating negative schizophrenic symptoms (NSS). In light of this large and growing literature, as well as of reconceptualizations of the underlying pathophysiology of NSS, the time may have come to reject models that assume "irreversibility" of NSS. However, flaws in existing studies prevent closure regarding the reversibility of, and by inference the treatability of, NSS. Guidelines for future studies are articulated, e.g., the need to distinguish primary from secondary NSS, to include drug-free subjects with a predominance of NSS in clinical trials, and to use well-validated and psychometrically sound instruments for assessing NSS.

Antipsychotic Agents↗
PubMedDate not supplied

Rubeosis iridis in "pseudogliomas".

A total of 85 eyes (75 patients) with pseudogliomas (i.e., certain conditions which simulate retinoblastoma, were examined histopathologically to determine the incidence of rubeosis iridis. Neovascularization of the anterior surface of the iris was found in 70 eyes (82%). The principal associated changes in these eyes were moderate to severe inflammation of the uveal tract and retinal detachment. These findings are interpreted as indicating that inflammation, retinal detachment, and/or ischemia are effective stimulants in producing iris neovascularization, and rubeosis is not a significant factor in differentiating eyes with retinoblastoma from those eyes with pseudogliomas.

Adolescent↗
PubMedDate not supplied

Treatment of arthritis with topical capsaicin: a double-blind trial.

The neuropeptide substance P has been implicated in the pathogenesis of inflammation and pain in arthritis. In this double-blind randomized study, 70 patients with osteoarthritis (OA) and 31 with rheumatoid arthritis (RA) received capsaicin (a substance P depletor) or placebo for four weeks. The patients were instructed to apply 0.025% capsaicin cream or its vehicle (placebo) to painful knees four times daily. Pain relief was assessed using visual analog scales for pain and relief, a categorical pain scale, and physicians' global evaluations. Most of the patients continued to receive concomitant arthritis medications. Significantly more relief of pain was reported by the capsaicin-treated patients than the placebo patients throughout the study; after four weeks of capsaicin treatment, RA and OA patients demonstrated mean reductions in pain of 57% and 33%, respectively. These reductions in pain were statistically significant compared with those reported with placebo (P = 0.003 and P = 0.033, respectively). According to the global evaluations, 80% of the capsaicin-treated patients experienced a reduction in pain after two weeks of treatment. Transient burning was felt at the sites of drug application by 23 of the 52 capsaicin-treated patients; two patients withdrew from treatment because of this side effect. It is concluded that capsaicin cream is a safe and effective treatment for arthritis.

Administration, Topical↗