Search PubMed⌕ Search

Biomedical subjects

D Alagille

Publications and source records attributed to D Alagille.

At least 109 records · Page 6Linked to original sources

Experience with choledocal cyst.

In a series of ten children operated upon for congenital choledocal cyst, it was noted that the diagnosis had often been delayed because of intermittent or moderate symptoms during the first year of life. We favor resection of the cyst, advocated by many authors recently, but it should be emphasized that this procedure is not without risk and may be quite a difficult undertaking. Late results were satisfactory on the whole, even in one child with severe portal hypertension. However, the moderate fibrosis found at operative biopsy and the still slightly enlarged liver at follow-up examination are reasons for long-term observation of these patients.

Bile Ducts, Intrahepatic↗

Hepatic ductular hypoplasia associated with characteristic facies, vertebral malformations, retarded physical, mental, and sexual development, and cardiac murmur.

Among 30 children with hepatic ductular hypoplasia and normal extrahepatic bile ducts, 15 formed a hemogeneous, readily recognizable group. In addition to chronic cholestasis, they have characteristic facies, a mesosystolic murmur, vertebral arch defects, growth retardation, mental retardation, and hypogonadism. Typical biochemical and histologic features aid in differentiation of this group from patients with other varieties of biliary disease.

Abnormalities, Multiple↗