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Biomedical subjects

D Ackery

Publications and source records attributed to D Ackery.

26 records · Page 2Linked to original sources
PubMed1982

The comparison of 8-hydroxyquinoline, tropolone, and acetylacetone as mediators in the labelling of polymorphonuclear leucocytes with indium-111: a functional study.

Tropolone forms a lipophilic complex with indium-111 which is capable of mediating the labelling of polymorphonuclear leucocytes (PMNs) by this isotope; labelling efficiencies are comparable with the best achieved using 8-hydroxyquinoline and acetylacetone. However, in terms of PMN chemotaxis and phagocytosis, tropolone is significantly less toxic than either of te other ligands. 8-Hydroxyquinoline was found to reduce PMN chemotaxis and phagocytosis to approximately 70% of the control values at a concentration of 20 micro M. Tropolone may prove a superior labelling reagent.

Chemotaxis, Leukocyte↗
PubMed1982

Myocardial imaging with dipyridamole: comparison of the sensitivity and specificity of 201Tl versus MUGA.

Myocardial imaging was performed at rest and after dipyridamole infusion using 201Tl and 99Tcm - gated blood pool studies (MUGA). Of 38 patients studied, 21 had coronary artery disease (CAD) and 17 were normal. With 201Tl imaging, 19 of 21 patients with CAD (sensitivity 88%) showed perfusion defects during dipyridamole. Of 17 normals 6 (specificity 65%) showed clear perfusion defects during dipyridamole. With MUGA, 2 of 15 patients with CAD (sensitivity 13%) developed abnormal wall motion during dipyridamole; both patients developed ST depression greater than 1 mm. Of 10 normals none developed abnormal wall motion. Twenty six of 38 patients developed angina during dipyridamole, which was reversed by aminophylline in 24 of 26. We suggest that dipyridamole infusion is effective for 201Tl-perfusion imaging, and easily performed, but is not suitable for MUGA studies where ischaemia is the required endpoint.

Aminophylline↗
PubMed1976

Whole-body and exchangeable potassium measurements in normal elderly subjects.

A comparison of total body potassium status of eighteen healthy subjects with normal renal function in the age group 65-85 years, measured by whole body counting and by total exchangeable potassium on plasma and urine samples taken at 24h, shows that there is no delay in exchange in radioactive potassium in the elderly, and that the exchangeable method gives a reliable value of total body potassium. The results suggest that the normal range for potassium per kilogramme body weight is lower for old persons than for younger age groups.

Aged↗
PubMed1972

Lung scintigraphy.

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Bronchial Neoplasms↗