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D A York

Publications and source records attributed to D A York.

161 records · Page 9Linked to original sources
PubMed1970

The effect of calcium ions on long chain fatty acid transport by slices of rat jejunum.

1. There is a large increase in palmitic acid uptake by rat jejunum slices when incubated in the presence of calcium. This effect is observed at both 37 and at 0 degrees C.2. The presence or absence of calcium in the incubation medium does not affect triglyceride synthesis from absorbed fatty acid.3. The release of synthesized triglyceride from the tissue into the medium is increased by calcium.4. The probability that calcium transport and long chain fatty acid transport may be interrelated at both the brush border and at the basal and lateral membranes of the intestinal mucosal epithelial cell is discussed.

Animals↗
PubMedDate not supplied

Conditioned taste aversion produced by inhibitors of fatty acid oxidation in rats.

The aversive effects of mercaptoacetate (MA) and methyl palmoxirate (MP) were examined in the present experiment. We used a conditioned taste aversion (CTA) paradigm for Sprague-Dawley rats maintained on a low- or high-fat diet, and determined that MA and MP both produce profound aversions to a novel saccharin solution. Because it is known that the stimulation of food intake brought about by MA administration is blocked by destruction of vagal afferents. we repeated the CTA experiment in control and capsaicin-treated rats. Results show that although the capsaicin-treated rats did not increase food intake after MA administration, the CTA produced by MA remained. Therefore, the neural pathways for the aversive and orexigenic effects of MA are distinct. We conclude that MA and MP are aversive, and that the aversive signal generated by MA does not involve vagal afferents or other fibers damaged by capsaicin.

Animals↗