Search PubMed⌕ Search

Biomedical subjects

D A Schmidt

Publications and source records attributed to D A Schmidt.

At least 55 records · Page 3Linked to original sources
PubMed1977

Effect of low dosage schedule of D-penicillamine on collagen cross-linking in a nine week immobilized rabbit knee.

Rabbits immobilized with one leg pinned in a fully flexed position, were treated with 60 mg of D-penicillamine/kg three times a week for 9 weeks. After this period of immobilization the animals were sacrificed and the periarticular connective tissue collagen reduced with [3H] NaBH4 for determination of collagen cross-links. There was a significant decrease in the formation of cross-links in the control and immobilized knee in the treated animals as compared to the untreated animals. Penicillamine also blocked the increase in DHLNL, HLNL and HHMD previously demonstrated in immobilized rabbit knees. This is the first demonstration that in vivo administration of penicillamine directly inhibits cross-linking reactions in collagen.

Animals↗
PubMed1976

Mucosal morphologic alterations in Thiry-Vella fistulas.

Three Thiry-Vella fistulas were surgically placed in each of 9 dogs to study the effects of x-irradiation on isolated loops of small intestine. Mucosal biopsy samples were removed from the fistulas for 5 days at 24-hour intervals after surgical operation to assess the morphologic alterations that occurred in the fistula mucosa following surgical isolation. There was a reduction of villus height during the 1st day, reduction of crypt depth on days 2 and 3, and stabilization of villus height and crypt depth during days 3 to 5 after surgical operation. The surgical technique and morphologic alterations observed in the mucosa of the fistulas during the 5 days after surgery are described.

Animals↗
PubMed1975

Neutropenia and salmonellosis in hospitalized horses.

Colitis due to salmonellae was diagnosed in 9 horses following hospitalization for various reasons at the University of Missouri Veterinary Teaching Hospital, from May, 1971, to April, 1972. Diarrhea, fever, and either a neutrophil count of less than or equal to 3,600/cmm or a rapid decline in neutrophil numbers were specific for salmonellosis. The value of hematologic survelillance in hospitalized Equidae was demonstrated in another group of 9 horses with neutropenia, each of which was promptly treated and did not develop colitis. Bacteriologic culturing of fecal samples from 28 clinically normal horses yielded only 2 salmonella isolations, S manhattan in each case. The serotyped salmonellae isolated from the patients with colitis were all S typhimurium, with similar antibiotic resistance patterns.

Agranulocytosis↗