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Biomedical subjects

D A Luke

Publications and source records attributed to D A Luke.

66 records · Page 4Linked to original sources
PubMed1979

Lobectomy with sleeve resection of the bronchus for malignant disease of the lung and the influence of the suture material used for the bronchial repair.

A series of 100 consecutive cases of lobectomy combined with sleeve resection of the bronchus for malignant disease of the lung is presented. In 13 of these cases a sleeve resection of the appropriate pulmonary artery was also carried out. An operative mortality of 8% was encountered and a crude 5-year survival of 40% was achieved. A comparison of absorbable and non-absorbable suture materials for the bronchial anastomosis indicated that the absorbable suture, Polyglycolic Acid (Dexon), minimized the morbidity from complications at the bronchial anastomosis.

Bronchi↗
PubMed1979

Metrical analysis of growth changes in the jaws and teeth of normal, protein deficient and calorie deficient pigs.

Weanling pigs were separated into three groups: control animals were allowed unlimited food; protein deficient animals were allowed unlimited carbohydrate or fat but restricted in protein intake; calorie deficient animals were restricted in total food intake. The skulls and teeth of animals killed at one year and at two years of age were measured from radiographs, and from the results were derived the following conclusions: (1) Pigs fed on protein and on calorie deficient diets all showed considerable retardation of the growth of jaws and teeth, consistently more severe in the calorie deficient than in the protein deficient animals. (2) The shape of the mandible was altered by both types of malnutrition, the height of the ascending ramus being reduced to a greater extent than either its anteroposterior width or the length of the body of the mandible. The labial alveolar process became more proclined with increasingly severe malnutrition. (3) The upper and lower jaws were retarded to a similar extent in both groups of experimentally malnourished animals. (4) Retardation of tooth growth was less severe than that of jaw growth. (5) Contralateral asymmetry of molar crown size in the protein deficient animals was initally quite marked, but when the teeth were approaching their final size the asymmetry was no greater than in control animals.

Animals↗
PubMed1976

Development of the secondary palate in man.

A study of secondary palate formation in man employing histochemical techniques indicates that (1) tongue muscles are sufficiently differentiated at the time of palatal shelf elevation to produce active tongue movements; (2) an embryo with asymmetrically arranged shelves and tongue suggests that the tongue is indeed active at this time; (3) few blood vessels are present beneath the epithelium at fusion sites both before and after fusion has occurred suggesting that this epithelium is not metabolically active; (4) only slight lysosomal enzyme activity is seen in the disintegrating epithelium at the junction of palatal shelves and nasal septum, and (5) macrophages are infrequent near to the disintegrating epithelium and their scarcity is consistent with the prolonged survival of epithelial rests in the midline of the human secondary palate.

Cell Differentiation↗
PubMed1976

Dental and craniofacial development in the normal and growth-retarded human fetus.

Craniofacial and dental development were examined in 32 human fetuses, 22--42 weeks of gestational age, nine of which were classified as light-for-dates (LFD). Statistically significant differences were detected between the LFD and the normal group with respect to upper and lower jaw size and cranial base length but not in the case of neurocranial length, orbital height or deciduous molar crown size. The structures which are least affected by intrauterine growth retardation are those whose growth rate is normally either low throughout the second half of gestation or falls substantially during the 10 weeks prior to term.

Body Weight↗
PubMedDate not supplied

Bronchopleural fistula after pneumonectomy.

BACKGROUND: Bronchopleural fistula (BPF) is an infrequent but life-threatening complication after lung resection. The incidence of BPF reported in the literature varies between 0 and 15%. AIM: To evaluate the incidence of BPF after pneumonectomy for primary lung cancer in a single practice using a single technique. METHODS: Hospital records of patients who underwent pneumonectomy from 1 January 1988 to 1 October 1998 were reviewed retrospectively. The bronchial stump was closed using a uniform hand suture technique. There was a total of 157 patients, including 118 males and 39 females with a mean age of 64 years (range 37-78). Sixty-two patients (39.5%) had a right pneumonectomy. RESULTS: Three patients developed BPF (1.9%). All occurred within seven days of the operation. Two of the three patients died. Ventilation for more than 24 hours was found to be the only significant risk factor for the development of BPF (p < 0.001). CONCLUSIONS: Hand suture closure of bronchial stump after pneumonectomy is a safe, reproducible and inexpensive technique, and a low incidence of BPF can be achieved.

Bronchial Fistula↗
PubMedDate not supplied

Pulmonary cystic hydatid disease in Ireland.

BACKGROUND: Hydatid disease is rare in Ireland and its incidence and prevalence are unknown. Most cases are diagnosed by a combination of clinical findings, morphological features on imaging and by serological testing. AIMS: We describe an Irish case of pulmonary hydatid disease detected at bronchoscopy by bronchoalveolar lavage, and discuss the diagnosis and treatment of the disorder. CONCLUSION: The diagnosis of this rare disease requires a high index of suspicion. Treatment is primarily surgical, with a role for antihelminthic agents.

Adult↗
PubMedDate not supplied

Treatment for mental illness and substance abuse in a public psychiatric hospital. Successful strategies and challenging problems.

Although the literature on dual diagnosis has grown considerably over the last several years, report describing inpatient treatment models are less common. We describe some of the major treatment concerns in the dural diagnosis literature, such as using 12-step self-help programs like Alcoholics Anonymous (AA) or Narcotics Anonymous (NA), dealing with different stages of treatment, and developing a program with integrated substance abuse and psychiatric treatment. The practical application of these treatment issues is featured by showing how they are incorporated into an innovative inpatient dual diagnosis treatment program at a public psychiatric hospital. Finally, the treatment program is described in detail regarding administrative issues, staff training, daily treatment schedules, and patient demographics.

Adult↗
PubMedDate not supplied

Cleft palate.

Explore the source record for details and available documents.

Cleft Palate↗