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Biomedical subjects

D A Jenner

Publications and source records attributed to D A Jenner.

43 records · Page 3Linked to original sources
PubMed1975

Influence of anti-oestrogens on the specific binding in vitro of (3H)oestradiol by cytosol of rat mammary tumours and human breast carcinomata.

The anti-oestrogenic potential of two nitrogen-mustard-containing compounds, I.C.I. 79792 and I.C.I. 85966, was studied. I.C.I. 85966 usually did not decrease specific binding of [3H]oestradiol by breast-tumour cytoplasmic proteins. I.C.I. 79792 decreased specific [3H]oestradiol binding, but not to the same extent as similar concentrations of I.C.I. 46474, diethylstilboestrol or dibutyldihydrostilboestrol.

Animals↗
PubMed1974

Endogenous steroid concentrations in human breast tumours determined by high-resolution mass fragmentography.

A pilot study of the endogenous steroid concentrations in human breast tumours was performed. The technique of high-resolution molecular-ion monitoring during combined g.l.c.-mass spectrometry was used to determine oestrone, oestradiol-17beta and oestriol in concentrations above 1ng/g wet wt. of tissue, and dehydroepiandrosterone, testosterone, androsterone (3alpha-hydroxy-5alpha-androstan-17-one) and 3beta-hydroxy-5alpha-androstan-17-one in concentrations exceeding 5ng/g, in extracts of five primary breast tumours.

Androsterone↗
PubMedDate not supplied

Catecholamine excretion rates in relation to life-styles in the male population of Otmoor, Oxfordshire.

The paper gives the results of the number of analyses of aspects of life-style and dietary patterns of members of the Otmoor population, in relation to their catecholamine excretion rates. The data reported here are restricted to males. Feelings of boredom were associated with low adrenaline excretion rates. Reported physical tiredness was associated with low adrenaline levels, while mental tiredness seems to be related to high adrenaline levels. People who regarded themselves as having a competitive personality, as being faced by a large number of life challenges, as having to meet self-set deadlines, as choosing to focus on more than one task at the same time, or as being under time pressure had high rates. Cigarette smoking and coffee consumption were related to high adrenaline excretion rates. Taken together these variables can explain 16-20% of variance in adrenaline excretion. Smoking and coffee consumption are of primary importance. The results of similar analyses of noradrenaline are reported.

Boredom↗
PubMedDate not supplied

Inter-population comparisons of urinary catecholamines: a pilot study.

Urinary catecholamine excretion rates, previously shown to be related to lifestyles and environmental influences, were investigated in three traditional-living populations and in an English population. Significant inter-population differences in excretion rates and in creatinine-related excretion were observed. These included high daytime levels of adrenaline output in the traditional groups relative to the English group. Methodological problems are discussed.

Adult↗
PubMedDate not supplied

Inter-population comparisons of catecholamine excretion.

Twenty-four hour urines were obtained from groups of male and female volunteers recruited from urban populations in developed and developing countries (UK, USA, Japan and Nigeria) an from agriculture-based Polynesian population (Tokelau Islands). The urines were collected on typical working days, with minimal disturbance to subjects' normal routines. High-performance liquid chromatography was used to determine catecholamine concentrations in each urine, providing a basis for calculation of total 24-hour excretion. Mean 24-hour excretion of noradrenaline and adrenaline was low in the Polynesians compared to the modern, urban groups, and low in women compared to men. Discussion of the results includes assessment of the possible influences of artefact, physical characteristics of the population samples, physical environment and social and psychological factors.

Age Factors↗