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Biomedical subjects

D A Hilding

Publications and source records attributed to D A Hilding.

At least 37 records · Page 2Linked to original sources
PubMed1968

Virus-like particles in the spiral ganglion of the guinea pig cochlea.

Double-walled spherical particles 100 millimicrons in diameter were accidentally discovered in the cytoplasm of spiral ganglion neurons of apparently healthy guinea pigs with normal startle responses. These particles in some ways resemble viruses of the herpes group and may represent a latent form of neuronal infection.

Animals↗
PubMedDate not supplied

Biological effects of ingested amosite asbestos, taconite tailings, diatomaceous earth and Lake Superior water in rats.

Because amphibole fibers were found in Lake Superior and in Duluth municipal water, this study was initiated to evaluate the carcinogenicity of ingested asbestos. Groups of 22-30 Sprague-Dawley rats were fed asbestos and related materials during their lifetime and were examined at autopsy after spontaneous death. Test materials were unfiltered Duluth city tap water, municipal water reservoir sediment suspension, taconite plant tailings, amosite asbestos (a "low-dose" group at 20 mg/rat . day an a high-dose group at 300 mg/rat . day) and diatomaceous earth; a control group drank fiber-free well water or filtered city tap water. Autopsy studies revealed no significant increase in the incidence of malignant tumors in any experimental group compared with that in the control group.

Animals↗
PubMedDate not supplied

Development of the labyrinthine receptors in the guinea pig, cat and dog.

Light and electron microscope observations were made on the vestibular receptors in fetal guinea pigs and cats, and in kittens and puppies. In the guinea pig hair cells were recognizable by 30 DBB (days before birth), myelinated preganglionary nerve fibers by 25 DBB, and neuro-epithelial synapses by 15 DBB. These observations can be correlated with the early development of the righting reflex in fetal guinea pig. Similar ultrastructural observations were made on cats and dogs at different times in development. A direct comparison between development in the vestibular system and the auditory system is possible since development of the organ of Corti in the same animals has previously been documented.

Age Factors↗
PubMedDate not supplied

Glycogen in the cochlea during development.

A recently developed technique for demonstrating glycogen by electron microscopy was used to study its location at various stages of cochlear development. It appears first in dispersed form in most of the cells of the otocyst at the stage of the 14-day rat embryo. Glycogen clums were found in Reissner's membrane at 17 days and in the future pillar cells shortly afterwards. Near the time of birth, glycogen appeared in the stria vascularis. By a few days after birth, heavy deposits were evident in the stria but glycogen had faded from the pillar cells and Reissner's membrane. Ten days after birth glycogen is no longer apparent in any of the cells of the cochlear duct except the outer hair cells.

Amylases↗