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Biomedical subjects

D A Harville

Publications and source records attributed to D A Harville.

4 recordsLinked to original sources

Confidence intervals for a variance ratio, or for heritability, in an unbalanced mixed linear model.

A procedure is presented for constructing an exact confidence interval for the ratio of the two variance components in a possibly unbalanced mixed linear model that contains a single set of m random effects. This procedure can be used in animal and plant breeding problems to obtain an exact confidence interval for a heritability. The confidence interval can be defined in terms of the output of a least squares analysis. It can be computed by a graphical or iterative technique requiring the diagonalization of an m X m matrix or, alternatively, the inversion of a number of m X m matrices. Confidence intervals that are approximate can be obtained with much less computational burden, using either of two approaches. The various confidence interval procedures can be extended to some problems in which the mixed linear model contains more than one set of random effects. Corresponding to each interval procedure is a significance test and one or more estimators.

Analysis of Variance

Index selection with proportionality constraints.

Tallis [1962] formulated and solved the problem of constructing a selection index whose use will produce changes in the means of genotypic values of various traits that are proportional to ultimately desired changes. Several meaningful variations of this problem are described, and their solutions are presented in a common framework.

Animals