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Biomedical subjects

D A HOWELL

Publications and source records attributed to D A HOWELL.

At least 19 recordsLinked to original sources
PubMed1964

OBSERVATIONS ON ANTICOAGULANT THERAPY IN THROMBOEMBOLIC DISEASE OF THE BRAIN.

According to a recently reported study, anticoagulant therapy appears to be ineffective in thrombotic cerebrovascular disease when viewed from the standpoint of mortality, although it does control thrombosis in animals, recurrent ischemic attacks and progression of infarction in patients with stuttering strokes. The efficacy of anticoagulant therapy in preventing a catastrophic stroke is analyzed in the present report. Of 92 untreated patients followed up for an average period of 36 months, 28 suffered a recurrent stroke, only two of these being trivial. One trivial and 12 catastrophic strokes occurred in the first 16 months. Of 103 patients treated with anticoagulants for an average period of 16 months, seven had recurrent strokes, but five of these were trivial. In the first 16 months one catastrophic and four trivial strokes occurred. Anticoagulant therapy appears to be useful in preventing catastrophic strokes in selected patients in whom the risk of recurrent strokes justifies the risks involved in this treatment.

Anticoagulants↗
PubMed1963

OBSERVATIONS ON STROKES AND CEREBRAL EDEMA WITH INTRACRANIAL TUMOURS.

Four patients who suffered strokes were found at autopsy to have intracranial tumours remote from the region responsible for the stroke, but the relevant cerebral white matter was swollen, pale yellow, and manifestly edematous. It is inferred from these observations that strokes in the presence of cerebral tumours may be caused by rapid fluctuations in the extent and intensity of the edema surrounding the cerebral tumour.A fifth patient is reported with recurrent strokes associated with a glioblastoma multiforme. He showed many dramatic remissions associated with treatment with adrenocorticotrophic hormone and equally prompt relapses when treatment was stopped. Similar cases in the literature are referred to. It is suggested that these hormones decrease the cerebral edema and thus produce the remissions.

Adenocarcinoma↗