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Biomedical subjects

D A Gould

Publications and source records attributed to D A Gould.

At least 37 records · Page 2Linked to original sources
PubMed1994

Allogeneic bone marrow transplantation.

From highly investigational to standardized therapy, allogeneic BMT has established its role in the treatment of selected diseases. Continued refinements in bone marrow transplantation will increase the number of potential candidates, reduce associated risks, and improve disease-free survival rates. With further exploration into its efficacy, allogeneic BMT will bring new challenges and opportunities for patients, families, and health care providers.

Bone Marrow Transplantation↗
PubMed1992

Case report: percutaneous transluminal angioplasty of the inferior mesenteric artery in the treatment of chronic mesenteric ischaemia.

Percutaneous transluminal angioplasty (PTA) of the superior mesenteric artery (SMA) and coeliac axis (CA) is a well recognized form of treatment for patients with chronic intestinal ischaemia and carries a low morbidity and mortality. We report a case where PTA of the inferior mesenteric artery in the presence of occluded SMA and CA proved both feasible and highly effective in abolishing the patient's symptoms.

Angioplasty, Balloon↗
PubMed1990

Vein graft surveillance improves patency in femoro-popliteal bypass.

Sixty-three patients undergoing femoro-popliteal bypass using autologous vein were prospectively screened for the development of graft related strictures by clinical assessment, intravenous digital subtraction angiography (IVDSA) and Duplex scanning. Eighteen strictures were identified in 14 grafts. Clinical examination detected only 11% of lesions, IVDSA detected 83% of lesions and Duplex scanning detected all 18 lesions. Seventeen lesions had occurred by 6 months from the time of operation which suggests that screening should begin early. Treatment by percutaneous transluminal angioplasty (PTA) was offered for eight strictures and dilatation was complete in all cases. No stricture recurred in the follow-up period. Cumulative patency in this series of screened and selectively treated vein grafts was compared with a previous series of 216 femoro-popliteal vein grafts and an improvement in 1 year potency of 15% was achieved (log rank test, chi 2 = 5.12, P = 0.02).

Angiography, Digital Subtraction↗
PubMed1986

Intramural pseudodiverticulosis--an unusual cause of benign oesophageal stricture.

Three cases of intramural pseudodiverticulosis of the oesophagus are described together with a review of the relevant literature. This unusual condition, diagnosed by characteristic features on the barium swallow, is associated with a high incidence of benign oesophageal stricture which responds readily to endoscopic dilatation.

Aged↗
PubMed1984

The primary role of ultrasound in evaluating right-sided diaphragmatic humps and juxtadiaphragmatic masses: a review of 22 cases.

Twenty-two successive patients presenting with localised humps on the right hemidiaphragm or juxtadiaphragmatic masses, as revealed on standard chest radiographs, were submitted for ultrasound examination. These were carried out irrespective of the patient's symptoms. Ultrasonography provided a useful adjunct to conventional chest radiography and accurately defined the extent of diaphragmatic humps and the contents of diaphragmatic herniations and juxtadiaphragmatic masses, clearly defining their relationship to the adjacent organs. In most cases further radiological investigations were unnecessary.

Aged↗
PubMed1983

Association between rising haemoglobin concentration and renal cyst formation in patients on long term regular haemodialysis treatment.

Seventeen of 20 (85%) patients on RDT for six to 13 years were found to have acquired renal cysts. There was a significant positive association between Hb and duration of RDT. The extent of cyst was positively and significantly correlated with the latest Hb and years on dialysis. There was also a significant positive correlation between size and years on dialysis only approached statistical significance. There was no correlation between kidney size and latest Hb. Complications in patients with acquired renal cysts appear to resemble those of familial polycystic disease with the added risk of neoplasia.

Adult↗
PubMedDate not supplied

Graft distortion after endovascular repair of abdominal aortic aneurysm: association with sac morphology and mid-term complications.

PURPOSE: To investigate the incidence, significance, and mechanism of stent-graft distortion after endovascular repair (EVR) of abdominal aortic aneurysm. METHODS: EVR of abdominal aortic aneurysm was performed in 51 cases (49 modular, bifurcated; 2 tube). Thirty-two patients were followed for 6 or more months and had equivalent baseline and follow-up images which could be used to determine changes in graft configuration. Sac dimensions were measured using computed tomographic (CT) images and graft-related complications were recorded. RESULTS: Amongst 32 patients evaluated on follow-up, there was graft distortion in 24. Distorted grafts were significantly (p = 0.002) associated with sac diameter reduction (mean 5 mm) and sac length reduction (mean 8.1 mm). All graft-related complications occurred in the limbs of eight distorted grafts, with a mean reduction of sac length in this group of 7.8 mm on reformatted CT images. CONCLUSION: There was a highly significant association between graft distortion and limb complications, and reduced sac dimensions.

Aged↗
PubMedDate not supplied

Efficacy versus effectiveness of carotid endarterectomy.

CONTEXT: Several well-known clinical trials have demonstrated that the value of carotid endarterectomy depends on preoperative symptoms and the degree of carotid artery stenosis. The benefit of surgery also depends on how the results of these clinical trials (defining the efficacy of carotid endarterectomy) are applied to actual clinical practice (the effectiveness of the procedure), where surgical risks are greater. COUNT: The number of carotid endarterectomies needed to prevent one major stroke or death--that is, the number needed to treat (NNT). CALCULATION: Reciprocal of the difference between the 5-year cumulative incidence of major stroke or death with medical therapy and the 5-year cumulative incidence of major stroke or death with carotid endarterectomy. DATA SOURCES: Efficacy was calculated with data from the North American Symptomatic Carotid Endarterectomy Trials and the Asymptomatic Carotid Atherosclerosis Study. In calculating effectiveness, we accounted for increased surgical mortality rates reported in population-based studies. RESULTS: For symptomatic patients, the NNT predicted by the effectiveness model differed little from that estimated by the efficacy model (10 versus 9 for severe carotid stenosis and 29 versus 23 for moderate carotid stenosis). However, the NNT predicted by the effectiveness model was substantially higher than that predicted by the efficacy model for patients with asymptomatic severe stenosis (63 versus 38). CONCLUSIONS: In symptomatic patients, carotid endarterectomy is both efficacious and effective for severe and (to a lesser extent) moderate carotid stenosis. However, in asymptomatic patients, the benefits observed in published trials may overestimate those likely to be achieved in clinical practice.

Aged↗