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Biomedical subjects

D A Gordon

Publications and source records attributed to D A Gordon.

At least 91 records · Page 5Linked to original sources
PubMed1983

Avascular necrosis of bone with rheumatoid vasculitis.

A 76-year-old woman with classical rheumatoid arthritis presented with a left groin mass associated with radiologic erosion of the adjacent bony public ramus. The hip joint was not involved. Computerized tomography showed an encapsulated cyst of the pubic ramus that was surgically excised and measured about 6 x 8 cm. Histologic examination of the cystic mass and adjacent bone showed marked avascular necrosis, surrounded by an acute necrotizing vasculitis with fibrinoid necrosis. We postulate that, in this case, rheumatoid vasculitis caused an avascular necrosis of the pubic ramus.

Aged↗
PubMed1983

A systematic controlled study of pulmonary abnormalities in rheumatoid arthritis.

We have conducted a prospective comparison of 155 rheumatoid patients and 95 control subjects. Both groups were selected without regard to respiratory status, but were comparable in age, sex and smoking experience. The prevalence of respiratory symptoms, of past respiratory illnesses and of pulmonary function findings of airway obstruction was similar in both groups. However, the rheumatoids showed an increased frequency of chest crackles and abnormal chest radiographs, and had pulmonary function changes suggestive of a restrictive ventilatory defect. These pulmonary abnormalities were associated with smoking, the presence of nonpulmonary extraarticular features, the level of rheumatoid disease activity and treatment with oral corticosteroid or gold.

Adult↗
PubMed1982

Prolongation of pancreatic islet cell allograft survival by graft pretreatment with antilymphoblast globulin (ALG).

The effect of antilymphoblast globulin (ALG) as a graft pretreatment for pancreatic islet cell allografts was tested in the canine model. Previous experiences on minimally immunosuppressed renal allografts had demonstrated significant prolongation of survival after graft pretreatment with ALG. ALG was injected with pancreatic islet cell fragment allografts that had been processed by mincing and subsequent collagenase digestion into the splenic pulp after total pancreatectomy of recipients immunosuppressed only with azathioprine following transplantation. Graft survival for pancreatic controls was 5.6 +/- 2.59 (M +/- SD) days. Islet cell allografts that received no ALG had a mean survival of 11.0 +/- 13.99 days (M +/- SD), P greater than 0.1). However, allografts pretreated with ALG had a significantly longer graft survival of 29.6 +/- 18.7 days (M +/- SD,P less than .01). Therefore, the spleen not only is an acceptable site for pancreatic islet cell transplantation in the dog, but significant graft prolongation can be achieved by utilization of ALG as a graft pretreatment modality for recipients receiving minimal immunosuppression with azathioprine.

Animals↗
PubMed1982

Immunologic response to liver cell allografts.

Hepatocyte transplantation is one modality that has been suggested for providing temporary hepatic support during periods of liver regeneration following acute hepatic failure. Although liver cells have been successfully transplanted in the rat, transplantation in a larger model is necessary before these techniques can be applied clinically. This study attempts to define the immunologic response of the canine recipients to intrasplenic hepatocyte allografts. Our results indicate that canine hepatocytes are highly immunogenic, initiating a host response which destroyed the allograft within one week post-transplantation (survival range 1-6 days, mean +/- SD = 3.33 +/- 1.86 days). Administration of azathioprine post-transplantation significantly (P less than 0.01) extended the survival of the hepatocyte allografts (survival range 3-9 days, mean +/- SD = 5.66 +/- 2.16 days. However, long-term survival was not seen using this type of minimal immunosuppression. Histologic observation also confirmed these findings. Based on these results, therefore, caution is recommended prior to the application of hepatocyte transplantation to the clinical setting.

Animals↗
PubMed1979

A measure of intensity of parental punishment.

To test the possibilities that antecedents and consequents of certain levels of intensity of punishment may have far-reaching effects on behavior, a self-report measure of parental intensity of punishment was developed. Consisting of 33 different situations to which parents react, scores from the instrument were found to be reliable over time. Further construct validity was demonstrated with a variety of predicted relationships between punishment intensity and parent and child characteristics. Five samples of subjects were used with over 400 families, high intensity of punishment scores were found to be related to mothers' lack of warmth and to her intrusiveness when playing with her child; children's maladjusted behavior; aggression and impulsivity in boys; withdrawal and inhibition in girls, and uncooperativeness. Inconsistency of parental punishment also was associated with maladjustment. Results were discussed in terms of Rotter's social learning theory.

Adolescent↗
PubMed1978

Structures and moelcular motions in alkaline earth hexammines.

The alkaline earth hexammines have novel structures and molecular motions. The ammonia molecules in these compounds adopt an entirely different geometry from that of normal ammonia. There are two motional transitions as the temperature is increased. The first transition is due to ammonia rotation, and the second results from ammonia diffusion.

Magnetic Resonance Spectroscopy↗