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Biomedical subjects

D A Fitzgerald

Publications and source records attributed to D A Fitzgerald.

7 recordsLinked to original sources
PubMed1995

Cutaneous infection with Mycobacterium abscessus.

Cutaneous infection with rapidly growing mycobacteria is uncommon and diagnosis may be difficult. However, the histopathological features are distinctive and may aid diagnosis. The three pathogenic species, Mycobacterium fortuitum, M. chelonae and M. abscessus, show major differences in their antimicrobial sensitivities, and species identification is therefore important. We describe a case of infection with M. abscessus, and discuss the clinical and pathological features of such infections, and approaches to their treatment.

Aged↗
PubMed1990

Seizures associated with 1% cyclopentolate eyedrops.

A 4.5 year old boy with cerebral palsy presented with seizures associated with facial flushing and tachycardia following the instillation of 1% cyclopentolate, a commonly used mydriatic in paediatric practice. He had no prior history of convulsions. This case demonstrates the uncommon, though serious, atropine-like side effect of cyclopentolate eyedrops (Cyclogyl, Alcon) in usual dosage in a brain damaged child without an epileptic focus.

Cerebral Palsy↗
PubMedDate not supplied

Expression of cytochrome P450 aldosterone synthase and 11 beta-hydroxylase mRNA during adrenal regeneration.

In situ hybridization histochemistry was used to monitor the expression of cytochrome P450 aldosterone synthase (P450aldo) and cytochrome P450 11 beta-hydroxylase (P45011 beta) mRNA in regenerating rat adrenals. Comparisons were made between regenerating adrenals from unilateral enucleated/unilateral adrenalectomized (ULE/ULA) and bilateral enucleated (BLE) rats. During the first week after enucleation, P45011 beta mRNA was expressed in all adrenals reflecting the presence of fasciculata cells; however, P450aldo mRNA was detected only in adrenals from ULE/ULA rats suggesting that the glomerulosa cell phenotype was absent after BLE. These findings suggest that the expression of glomerulosa cells during the early period of regeneration is influenced by the presence of a second regenerating adrenal.

Adrenal Glands↗