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Biomedical subjects

D A Edelman

Publications and source records attributed to D A Edelman.

At least 55 records · Page 3Linked to original sources
PubMed1986

The intrauterine device and ectopic pregnancy.

Based on data given by case-control and cohort studies the relationships between current and past IUD use, duration of IUD use and the type of IUD were evaluated to determine the risk of ectopic pregnancy among IUD users. The results of this review indicate that current and past IUD users do not have an increased risk of ectopic pregnancy. No relationship was found between the duration of IUD use, for either current or past IUD users, and the risk of ectopic pregnancy. Pooled data from clinical studies of different types of IUD showed that the lowest risk of ectopic pregnancy was for users of copper-bearing IUDs, and the highest risk was for users of progesterone-releasing IUDs. Further research is needed to evaluate the ectopic pregnancy risks to past IUD users, especially in view of recent studies which have shown that these women may be at a higher risk of infertility.

Female↗
PubMed1986

Pelvic inflammatory disease and the IUD.

The evidence for the association between IUD use and PID is reviewed based on the results of case-control and cohort studies. Both types of epidemiologic studies are described briefly. Most case-control studies are hospital-based and show that IUD users have a higher risk of having PID compared to women using other contraceptive methods. The results of case-control and cohort studies, however, are not in agreement. Considered collectively, cohort studies show that the PID rates are the same for users of all types of IUDs. This rate is similar to the PID rate in the general population not associated with abortion, childbirth or surgery.

Female↗
PubMed1986

Longterm use of the Today contraceptive sponge.

Users of the Today contraceptive sponge who participated in a comparative trial of the sponge and diaphragm were followed up for an additional year. There were no serious adverse effects attributable to sponge use during the second year of use. The second year life-table pregnancy rate for sponge users was significantly lower (p less than 0.05) than the first year rate. The pregnancy rates for first time sponge and diaphragm users were similar (p greater than 0.10) and both rates improved with increasing user experience.

Adult↗
PubMed1985

Worldwide method effectiveness of the Today vaginal contraceptive sponge.

The Today vaginal contraceptive sponge is made of polyurethane and contains 1 gram of the spermicide nonoxynol-9. Following preclinical and phase I and II clinical trials, extensive worldwide phase III trials were conducted. These multiclinic trials were conducted according to a common protocol with regularly scheduled follow-up visits and examinations. The cumulative first year method effectiveness rate (life table) was 90 per 100 women. The second year rate was 97 per 100 women. No statistically significant difference was found in method failures between nulliparous and parous women. No serious complications occurred in over 1000 women-years of sponge use.

Adult↗
PubMed1985

Transcutaneous procedures for male sterilization.

Outside the People's Republic of China transcutaneous methods of male sterilization are not widely used, even though there are advantages of these methods over surgical vasectomy procedures. Methods of transcutaneous sterilization (intratesticular, intraepididymal, and intravasal) that have been evaluated in men are reviewed.

Animals↗
PubMed1984

A comparative trial of the Today contraceptive sponge and diaphragm.

A comparative trial was conducted in the United States to compare the Today contraceptive sponge and the diaphragm used with spermicide. Subjects were randomly assigned to contraceptive methods and were followed up for 1 year. None of the subjects were previous sponge users, but about 30% were previous diaphragm users. The overall cumulative 1-year life-table pregnancy rate was higher for sponge users compared to diaphragm users. No serious side effects occurred with either product. The discontinuation rates for allergic-type reactions and discomfort were higher for sponge users. Similar rates of method-related complaints and discontinuation rates for personal and product-related reasons suggest there were no differences in the acceptability of the two products. In this trial, the allowable use time for the sponge was 2 days. The sponge is now recommended for 1-day use. The overall results of the study indicate the sponge to be a safe and acceptable method of contraception with an effectiveness rate in the range of that for other vaginal contraceptives.

Adolescent↗
PubMed1984

Vaginal contraception: an overview.

Some of the more recent advances in vaginal contraception (suppositories, diaphragms, cervical caps, contraceptive sponges) are reviewed, and, when available, data relating to their safety and effectiveness are presented.

Contraception↗
PubMed1984

Postpartum insertion of modified intrauterine devices.

The immediate postpartum insertion of standard intrauterine devices (IUDs) and those specially modified for postpartum use was evaluated in a multicenter clinical trial. The immediate postpartum insertion of IUDs was not associated with any increased risk of perforation or infection, although expulsion rates were higher than with interval insertions. The expulsion rate varied widely between centers using similar devices, suggesting that training in insertion is essential. Postpartum IUD insertions can be a practical contraceptive option for patients and providers of medical services.

Adult↗
PubMed1983

Other milestones.

Explore the source record for details and available documents.

Abortion, Septic↗
PubMed1983

Comparative trial of the contraceptive sponge and diaphragm. A preliminary report.

We evaluated the results from an ongoing comparative trial of the VLI contraceptive sponge and the diaphragm used with a spermicide. Among women who were not using vaginal contraceptives when enrolled in the study, the cumulative 12-month pregnancy rates were similar for the two contraceptive methods. Among women who were using vaginal contraceptives (principally diaphragms) when they were enrolled in the study, the group of women assigned to the diaphragm, as might be expected, had a significantly lower pregnancy rate. Rates of side effects and acceptability appeared to be similar for sponge and diaphragm users.

Adolescent↗