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Biomedical subjects

D A Czech

Publications and source records attributed to D A Czech.

28 records · Page 2Linked to original sources
PubMed1984

Drinking behavior is modulated by CNS administration of opioids in the rat.

While opiate antagonists have been shown to reliably attenuate drinking following both central and peripheral administration, relatively few data exist on the effects of agonist agents on this behavior. To address this issue, two opiate agonists, morphine sulfate, a mu agonist, and [D-ala2, D-leu5]-enkephalin (DADLE), a semi-synthetic delta analog of a delta agonist, were administered into several CNS sites in rats. There was a dose-related, naloxone-reversible reduction of water intake following morphine injections into the lateral hypothalamus (LH) and preoptic area (POA). In addition, injections of DADLE also attenuated drinking when injected into LH and POA, but not following the ventral tegmental area or zona incerta administration. These data are discussed in view of a role for the endogenous opioid peptides in the regulation of drinking behavior.

Animals↗
PubMed1983

Naloxone-induced hypodipsia: a CNS mapping study.

Opiate antagonists have been shown to reliably attenuate drinking behavior. Recent research points to a central site of action for this antidipsogenic effect. To pursue this issue of site specificity, naloxone, a specific opiate antagonist, was delivered into a number of discrete subcortical areas in 23 hour water-deprived rats. Water intake was measured at 5, 15, 30 and 60 minutes post drug injection. Compared to saline control injections, naloxone reliably depressed water intake, in a dose-related manner, in lateral hypothalamus, preoptic area and zona incerta. Previous research has repeatedly implicated these areas in drinking behavior. Placements which were not generally effective included lateral ventricle, nucleus accumbens, substantia nigra and cortex/corpus callosum. Latency to drink was never affected by any dose of naloxone injected into any site, suggesting an opioid influence on mechanisms involved in termination and/or maintenance rather than on initiation of drinking.

Animals↗
PubMed1980

Naloxone depresses osmoregulatory drinking in rats.

The effect of an opiate antagonist, naloxone, on hypertonic NaCl-induced drinking was studied in rats in a within-subject design. Naloxone reduced drinking at all dosage levels used (0.3-10.0 mg/kg) when compared to a control condition. These results extend previous findings of naloxone mediated reduction in fluid intake in water deprived and osmotically challenged animals. Naloxone's effects on fluid intake seems to be independent of procedure employed, and thus quite general. Possible mechanisms were considered.

Animals↗
PubMed1977

Effect of tetraethyl lead and restricted food intake on locomotor activity in the rat.

The effect of tetraethyl lead (TEL) and restricted food intake on spontaneous locomotor activity in male albino rats was investigated. Forty animals were injected intraperitoneally with 4, 7, 10 or 13 mg/kg body weight of TEL in peanut oil, or a peanut oil placebo. Forty additional animals were food yoked to lead treated animals as a control procedure to hold food intake constant between lead treated and lead free animals. A comparison of pre- and posttreatment measures revealed significant decreases in food intake and increases in activity levels at dosages of 7, 10 and 13 mg/kg of TEL. In addition, food intake and activity were significantly correlated in both lead treated and yoked groups. The issue of factors associated with reduced food intake playing a role in observed activity level increases was raised.

Animals↗
PubMed1976

Effect of tetraethyl lead on food and water intake in the rat.

The effect of tetraethyl lead (TEL) on food and water intake in adult male albino rats was studied. Animals received 1, 4, 7, 10, or 13 mg/kg body weight of TELin peanut oil, or a peanut oil placebo, via either intragastric (IG) intubation or intraperitoneal (IP) injection. For food intake, route of administration was a significant factor and, compared to baseline levels, food intake was significantly depressed at dosage levels of 7, 10, and 13 mg/kg for both IP and IG administration. Further, the time course of food intake differed significantly across route of administration. Water intake was also significantly depressed at 7, 10, and 13 mg/kg, but route of administration was not a critical factor. Results were discussed in relation to clinical and experimental data on lead intoxication, and were viewed as severely limiting the utility of employing food and/or water as motivational variables in assessment of behavioral effects linked to TEL poisoning.

Animals↗
PubMedDate not supplied

Triethyl lead attenuates feeding and drinking, and induces a conditioned taste aversion, in adult rats.

The effect of triethyl lead (TEL) on ingestive behavior in adult male rats was studied in two experiments. In experiment 1, ad lib food and water intakes were monitored following SC injection of 1, 4, or 7 mg/kg body weight of TEL or vehicle; both were significantly attenuated at 4 and 7 mg/kg doses. In a second experiment, the same doses of TEL were given SC in a conditioned taste aversion (CTA) paradigm. Following a single pairing, a dose-related reduction in intake of a 0.1% saccharin solution was observed at all doses tested. Sensitivity of behavioral measures and potential role of discomfort in TEL-induced feeding/drinking shifts were considered.

Animals↗
PubMedDate not supplied

Some aspects of feeding and locomotor activity in adult rats exposed to tetraethyl lead.

The potential relationship between concomitant changes in feeding behavior and locomotor activity in rats exposed to tetraethyl lead (TTEL) was investigated. Two groups of rats were injected IP with a dose of TTEL (7 mg/kg) that depresses food intake. One group served as a control to replicate this effect. Animals in the second lead group were food yoked to animals in a placebo group. Food intake of rats in group 2 was maintained at or near the level of their yoked control via intragastric intubation. Food loads did not maintain body weights at control levels; however, locomotor activity level in both lead treated groups was significantly elevated above controls during normophagic periods when body weights approximated control levels as well as during hypophagic, low body weight periods. These observations suggest that activity shifts are not mediated in a simple way by factors linked to reduced food intake. Two additional experiments were briefly reported in which TTEL-exposed rats were challenged with 2-deoxy-D-glucose and insulin, either during their hypophagic phase or during a later recovered (normophagic) period. Feeding in response to glucoprivic challenge was similar to that of control animals under both conditions. Results were discussed.

Analysis of Variance↗