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Biomedical subjects

D A Cozanitis

Publications and source records attributed to D A Cozanitis.

11 recordsLinked to original sources
PubMed1979

Atropine versus glycopyrrolate. A study of intraocular pressure and pupil size in man.

Following control observations of intraocular pressure and pupil size, in doses suitable for pre-anaesthetic medication, glycopyrrolate (0.004 mg/kg) and atropine (0.01 mg/kg) were given intramuscularly to healthy volunteers in a randomised, cross-over fashion. No significant change in either intraocular pressure or pupil size was noted 45 min after drug administration.

Adult↗
PubMed1979

Atropine versus glycopyrrolate. A study using repeated doses of suxamethonium in man.

Intermittent doses of suxamethonium have been known to result in bradycardia changes in cardiac rhythm. In order to assess the efficacy of a newer quaternary ammonium antimuscarinic, glycopyrrolate, on the cardia effects of intermittent suxamethonium, 28 patients received this drug intravenously just before induction of anesthesia. For comparison, 28 other patients were given atropine. In the atropine series, three patients developed bradycardia while none of those of the glycopyrrolate series did so. In addition, more patients had cardiac arrhythmias in the atropine group. Although no statistically significant differences were seen, clinically, glycopyrrolate seems to afford better protection against the cardiac changes resulting from intermittently administered suxamethonium.

Adult↗
PubMed1978

Galanthamine.

Explore the source record for details and available documents.

Behavior↗
PubMed1978

Bacterial contamination of telephones in an intensive care unit.

Pathogenic and potentially pathogenic bacteria were found on telephones of an intensive care unit. Direct contamination by microorganisms from throats, hands, and noses of the staff members is real although airborne contamination would also play a role. The awareness of environmental risk in intensive care units is underlined.

Asepsis↗
PubMed1977

The potency ratio of galanthamine and neostigmine on the reversal of the tubocurarine block in the isolated rat diaphragm.

The potency ratio of galanthamine and neostigmine was studied on the rat phrenic nerve-diaphragm preparation. This ratio appeared to be about 18 on a weight base. The potency ratio in man in vivo, is about 20. Hence we concluded that this potency ratio might mainly be due to the difference in potency on the neuromuscular transmission and not to kinetic differences.

Animals↗
PubMed1977

Galanthamine hydrobromide, a longer acting anticholinesterase drug, in the treatment of the central effects of scopolamine (Hyoscine).

Galanthamine hydrobromide, an anticholinesterase drug capable of penetrating the blood-brain barrier, was used in a patient demonstrating central effects of scopolamine (hyoscine) overdosage. It is longer acting than physostigmine and is used in anaesthesia to reverse the non-depolarizing neuromuscular block. However, studies into the dose necessary to combating scopolamine intoxication are indicated.

Adult↗