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Biomedical subjects

D A Cooley

Publications and source records attributed to D A Cooley.

At least 19 recordsLinked to original sources

Aortic aneurysm operations: past, present, and future.

Effective methods to treat aortic aneurysms are now available, although these lesions still challenge the cardiovascular surgeon. Attempts at treatment began in earnest in the 1800s, with the introduction of indirect and direct methods of repair. A major breakthrough occurred in the late 1800s, when Dr Rudolph Matas devised a method for internal repair of aneurysms in which continuity of blood flow was restored by excising the diseased portion of the lesion and creating a tunnel through the remaining normal portion. Matas named this technique reconstructive endoaneurysmorrhaphy. Until that time, surgeons had treated aneurysms by ligating the parent vessel with a Hunterian ligature or introducing foreign material to promote coagulation. Ligating the aneurysm rendered the extremities vulnerable to ischemic damage, however, and results were unpredictable with the use of various foreign materials. Around the turn of the century, Carrel began experimenting with different techniques for vascular anastomoses. The work of these early pioneers formed the basis for much of the modern treatment of aneurysms of the thoracic aorta. My experience began in 1950, when I excised a large aortic aneurysm in one of Dr Alfred Blalock's patients. The patient survived and was cured. After that experience, I knew that aortic aneurysms could be treated successfully by aggressive surgical means. Treatment has changed, however, from the early emphasis on excising the lesion to the present practice of restoring circulatory continuity with a suitable graft, ie, endoaneurysmorrhaphy. The development of reliable synthetic grafts has been one of the most important advances in the treatment of aneurysms. The surgical technique used today depends on the anatomic location of the aneurysm, which can occur anywhere from the aortic annulus and aortic valve to the distal thoracic aorta and visceral vessels in the abdomen.

Aortic Aneurysm

Selective hypothermia in repair of aneurysms of the descending aorta.

Since 1991, we have used a simple, single-clamp technique with open distal anastomosis to repair aneurysms of the descending aorta. To enhance the results of the single-clamp technique in a recent high-risk patient, we used selective hypothermia, cooling primarily the tissues and organs supplied by the aorta and tributaries distal to the left subclavian artery. This preliminary report describes the technique and gives the rationale for its use.

Aged

Concomitant occlusive disease of the coronary arteries and great vessels.

BACKGROUND: Although an increasing number of elderly and high-risk patients, including those with generalized atherosclerosis, are undergoing coronary revascularization, few reports exist regarding the management of patients who have both occlusive disease of the great vessels and coronary artery disease. METHODS: Between 1972 and 1996, 31 consecutive patients (mean age, 56.5 years; 74% men) with multivessel coronary artery disease and symptomatic occlusive disease of the great vessels (25 single-vessel, 80.6%; 6 multiple-vessel, 19.4%) had 40 great vessels reconstructed by transthoracic bypass (n = 17, 42.5%), transthoracic endarterectomy (n = 8, 20%), or extrathoracic bypass (n = 15, 37.5%). All patients had simultaneous coronary artery bypass grafting (mean, 2.6 grafts per patient), and 8 patients had 10 distal carotid bifurcation endarterectomies (6 staged, 4 simultaneous). RESULTS: The early primary patency rate was 100%, and symptoms resolved completely in all 31 patients. There was 1 in-hospital death (3.2%) in a patient who had a respiratory arrest 11 days after operation. Perioperative morbidity included two myocardial infarctions (6.5%) and one opposite-hemisphere, embolic stroke (3.2%). Long-term follow-up of the 30 survivors (167.4 patient-years; mean, 5.6 years per patient) documented 5- and 10-year actuarial survival rates of 88.6% and 60.4%, respectively, with a 100% late brachiocephalic primary patency rate. Ten-year actuarial rates of freedom from the following events were as follows: death, 60.4%; myocardial infarction, 82.5%; stroke, 90.9%; percutaneous transluminal coronary angioplasty or redo coronary artery bypass grafting, 95.2%; and vascular operation or amputation, 78.4%. CONCLUSIONS: Depending on the anatomic distribution of the disease, an integrated approach to great vessel reconstruction that incorporated transthoracic and extrathoracic approaches and techniques of endarterectomy and bypass resulted in few adverse outcomes and excellent long-term patency. Simultaneous revascularization of the great vessels and coronary arteries can produce immediate and long-term, symptom-free outcome with acceptably low operative risk.

Aged

Transmyocardial laser revascularization in allograft coronary artery disease.

We used transmyocardial laser revascularization to treat accelerated cardiac allograft atherosclerosis in 2 patients. One patient received transmyocardial laser revascularization as sole therapy, the other as an adjunct to coronary artery bypass grafting. The systolic function improved in both patients, although the patient who had adjunctive transmyocardial laser revascularization died of systemic infection and renal failure on postoperative day 55. The second patient is alive and well 1 1/2 years after the laser procedure. We discuss 4 other patients who received transmyocardial laser revascularization treatment elsewhere in the United States. Transmyocardial laser revascularization has the potential to become important in the treatment of transplant atherosclerosis. Randomized clinical trials are warranted to assess the efficacy of transmyocardial laser revascularization in this setting.

Coronary Artery Bypass

Minimally invasive valve surgery versus the conventional approach.

As a result of reports touting the effectiveness of minimally invasive valve operations, many cardiovascular surgeons and their patients are beginning to believe that smaller incisions are always better. According to its proponents, the minimally invasive approach results in less pain, a faster recovery, and a more satisfactory cosmetic result. Proponents also believe that the operation can be done safely and effectively at a lower cost than traditional surgical approaches. This may not be the case, however, and additional prospective studies must be done before firm conclusions can be drawn. For example, cardiopulmonary bypass, myocardial ischemia, and overall operative times are significantly longer (40% or more) for minimally invasive surgical procedures. Morbidity and mortality rates do not appear to be decreased, the length of hospital stay varies by only 1 or 2 days, and patients do not necessarily report less postoperative pain. When the conventional technique is used, the operation can be performed precisely and expeditiously. Should complications occur, the surgeon will have direct access to the heart. The cost of a conventional procedure should not be much more than that of a minimally invasive procedure, and in some instances it may even be less-particularly when the less invasive procedure significantly extends the operating room time or requires additional monitors or costly disposables.

Cardiac Surgical Procedures

Postinfarction ventricular septal rupture.

Postinfarction ventricular septal rupture is an uncommon but serious complication of acute myocardial infarction. Although I have tried various methods for repairing postinfarction septal defects, I recently began to use an exclusion technique, which is an extension of the intracavitary repair method that I use to treat ventricular aneurysms. This exclusion technique yields satisfactory results (early mortality rate, 36.4%), even in patients in severe cardiogenic shock.

Animals

Single-clamp repair of aneurysms of the descending thoracic aorta.

Ischemic injury of the spinal cord remains a serious threat during the surgical treatment of aneurysms of the descending and thoracoabdominal aorta. Time is the critical factor in preventing spinal cord injury. The author uses a single-clamp technique that is simple and limits distal dissection, heparin dosage, and cross-clamp time, thus reducing the risk of paraplegia.

Aortic Aneurysm, Thoracic

Transmyocardial laser revascularization. Does it have a role in the treatment of ischemic heart disease?

Transmyocardial laser revascularization, with or without coronary artery bypass grafting, is an alternative modality for complete revascularization in selected patients with coronary artery disease. Arguably, this modality works by shunting left ventricular blood directly into the ischemic myocardium via laser-mediated transmural channels. In clinical trials, drilling of laser channels has been strongly correlated with long-term improvement of angina, but a causal relationship has not yet been documented. For now, the usefulness of transmyocardial laser revascularization and the nature of its mechanism remain controversial. Some researchers question the existence of myocardial sinusoids altogether. Others question the physiologic possibility of moving blood from the left ventricular cavity into the myocardium against a pressure gradient. Further questions concern the possible routes through which the additional blood gains access to the myocardium; the difficulty of objectively documenting improved myocardial perfusion after transmyocardial laser revascularization; and the nature of the mechanism responsible for the observed clinical benefit. This article examines the different aspects of this controversy and discusses the current status of transmyocardial laser revascularization, as well as possible future directions.

Cardiac Output

Limited-access coronary artery bypass grafting. The Texas Heart Institute experience.

Limited-access coronary artery bypass grafting, without the aid of cardiopulmonary bypass, is being performed with increased frequency, but its indications are not well defined. To determine the outcome of, and indications for, this procedure, we analyzed our experience with limited-access coronary artery bypass grafting. Between February 1996 and June 1998, 84 patients underwent limited-access coronary artery bypass grafting at our institution. We retrospectively divided these patients into 2 groups: a high-risk group with complex disease and multiple comorbidities (n = 56), and a low-risk group with uncomplicated disease (n = 28). There were 2 perioperative deaths (2%), and both of them occurred in high-risk cases. Early and late complications included myocardial infarction (2 cases), recurrent angina necessitating revascularization (2 cases), and multisystem dysfunction (1 case). Compared with conventional bypass grafting, limited-access coronary artery bypass grafting offered a smaller skin incision, fewer arrhythmias, less blood loss, less need for inotropic drugs, shorter hospitalization, lower cost, and quicker recovery time. Limited-access coronary artery bypass grafting might have a role in treating high-risk patients who have complex disease and require single-vessel bypass. Anastomosis can be challenging, however, if the target coronary artery is small, calcific, or intramyocardial. Moreover, the long-term results are unknown. Therefore, nonselective use of limited-access coronary artery bypass grafting is unjustified.

Aged

Long- and short-term effects of transmyocardial laser revascularization in acute myocardial ischemia.

BACKGROUND AND OBJECTIVE: This study examined the effect of transmyocardial laser revascularization (TMLR) on infarct size and global and regional left ventricular (LV) function. STUDY DESIGN/MATERIALS AND METHODS: Acute ischemia was induced in 24 dogs by ligating the left anterior descending artery. TMLR was done through a left thoracotomy in 12 dogs. The 12 control dogs had ligation only. Global and regional LV function were measured before ligation, then at 6 hours or 3 months after ligation. We calculated the volumetric ratio of damaged myocardium to myocardium at risk (Vd/Vr). RESULTS: At 6 hours, global compensation despite regional dyskinesia was universal; Vd/Vr was the same in control and TMLR dogs. At 3 months, global function during stress was significantly higher in TMLR dogs than in control dogs (P < .05); regional contractions were synergic only in TMLR dogs; mean Vd/Vr was significantly lower in TMLR dogs. CONCLUSION: TMLR limits infarct expansion and improves long-term global and regional function after acute ischemia.

Animals

Refractory angina pectoris in end-stage coronary artery disease: evolving therapeutic concepts.

Refractory angina pectoris in coronary artery disease is defined as the persistence of severe anginal symptoms despite maximal conventional antianginal combination therapy. Further, the option to use an invasive revascularization procedure such as percutaneous coronary balloon angioplasty or aortocoronary bypass grafting must be excluded on the basis of a recent coronary angiogram. This coronary syndrome, which represents end-stage coronary artery disease, is characterized by severe coronary insufficiency but only moderately impaired left ventricular function. Almost all patients demonstrated severe coronary triple-vessel disease with diffuse coronary atherosclerosis, had had one or more myocardial infarctions, and had undergone aortocoronary bypass grafting (70% of cases). We present three new approaches with antiischemic properties: long-term intermittent urokinase therapy, transcutaneous and spinal cord electrical nerve stimulation, and transmyocardial laser revascularization.

Aged

Correction of anomalous systemic venous drainage: transposition of left SVC to left PA.

In some patients, a persistent left superior vena cava drains into the left atrium (rather than the right) and may produce a symptomatic right-to-left shunt. We describe an extracardiac approach for correcting anomalous systemic venous drainage when the innominate vein is absent. In this technique, the left superior vena cava is transposed to the left pulmonary artery.

Arteriovenous Shunt, Surgical

Is an integrated approach warranted for concomitant carotid and coronary artery disease?

BACKGROUND: The management of patients with severe, concomitant coronary and carotid artery occlusive disease is controversial. METHODS: Between 1975 and 1996, 512 patients (mean age, 64.9 years; 70% male) were admitted for coronary revascularization; 316 (61.7%) had asymptomatic, severe carotid disease (stenosis > 70%) and 196 (38.3%) had symptomatic carotid disease (159 [31.1%] with transient ischemia and 37 [7.2%] with completed stroke). In group 1, coronary revascularization and carotid endarterectomy were simultaneously performed in 255 patients (49.8%) with unstable angina. In group 2 (staged approach), carotid endarterectomy was performed before coronary revascularization in 257 patients (50.2%) without unstable angina. RESULTS: Before 1986, the incidence of stroke and death was greater in group 1 (n = 149) than in group 2 (n = 156) (14 [9.4%] versus 4 [2.6%]; p < 0.01). Since 1986, outcomes in group 1 (n = 106) and group 2 (n = 101) have been similar for stroke (2 [1.9%] versus 2 [2.0%]), death (4 [3.8%] versus 3 [3.0%]), and myocardial infarction (4 [3.8%] versus 5 [5.0%]). Significant univariate and multivariate predictors of adverse outcome were primarily heart-related (reoperation, intraaortic balloon use, ejection fraction < 0.50, and angina grade 4 for death; age > 70 years and congestive heart failure for stroke). CONCLUSIONS: Despite highly selected populations, contemporary surgical results do not indicate that staged treatment of severe, concomitant coronary and carotid artery occlusive disease has an advantage over simultaneous treatment. Advances in myocardial protection and perioperative hemodynamic management may account for the low incidences of stroke and death in these operations.

Adult

Early development of congenital heart surgery: open heart procedures.

Experience in the surgical management of congenital heart defects led to the advent of open heart surgery as it is known today. Only after 1938, when Robert Gross first ligated a patent ductus arteriosus, did congenital anomalies yield to correction. Success with these anomalies encouraged surgeons to attempt other extracardiac and intracardiac repairs. These attempts resulted in a steady flow of advances that culminated in the practical application of cardiopulmonary bypass and the procedures it made possible. Today, less than 60 years since Gross's landmark operation, surgical intervention can fully or partially correct 95% of congenital heart defects.

Cardiac Surgical Procedures