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Biomedical subjects

D A Clarke

Publications and source records attributed to D A Clarke.

24 records · Page 2Linked to original sources
PubMed1972

Arbovirus infections in man in British Columbia.

During the summer of 1971, the first laboratory-proved cases of acute encephalitis in man due to any of the known arboviruses occurred in the south-central region of British Columbia. Five human cases of encephalitis with two deaths were diagnosed; three of these patients, including one of the fatalities, were proven in the laboratory to have contracted western equine encephalitis.During 1968 and 1969, a human serum survey undertaken in approximately 2000 life-long residents of the province discovered low levels of hemagglutinin-inhibiting and/or complement-fixing as well as neutralizing antibodies for western equine encephalitis, St. Louis encephalitis, Powassan encephalitis, California encephalitis and Colorado tick fever. Evidence of recent sub-clinical infection was detected in some cases.

Adolescent↗
PubMedDate not supplied

Mixed leukocyte reaction in rheumatoid arthritis.

The mixed leukocyte reaction (MLR) responses of 29 patients with classic rheumatoid arthritis (RA) were compared with those of 24 age- and sex-matched healthy controls. Pools of stimulating cells were selected to include the major cross-reacting HL-A specificities. In pooled human serum the MLR response of the RA lymphocytes was significantly enhanced relative to the response controls (P less than 0.05). In autologous serum there was suppression of the MLR response in patients with RA which correlated with disease activity. The data suggest the presence of an intrinsically enhanced cellular reactivity of RA lymphocytes suppressed by serologic factor(s). The mechanisms of this enhancement of suppression are discussed.

Adult↗
PubMedDate not supplied

Diastema preservation in resin-bonded fixed partial dentures.

The etched-metal, resin-bonded fixed partial denture has evolved rapidly from its origination as an extracoronal splint. Technologic advancements in both resin chemistry and retentive surface etching techniques have markedly improved the quality of the prosthesis. Today, resin-bonded fixed partial dentures are an effective, conservative means of replacing missing teeth when specific contra-indications--long spans, insufficient sound enamel, malocclusion, pathologic occlusal habits--are identified and avoided. A universally-accepted standard preparation does not exist for resin-bonded fixed partial dentures; rather, common principles of tooth reduction are agreed upon by most authors. This case report details necessary modifications in typical preparation and framework design that must be included to maintain a midline diastema when such spacing is required or preferred by the patient.

Adolescent↗
PubMedDate not supplied

Erythrocyte cation cotransport and countertransport in essential hypertension.

We studied erythrocyte cation cotransport and countertransport systems in 21 and 27 patients with essential hypertension, respectively, all of whom were under 50 years of age, had a diastolic blood pressure level greater than 100 mm Hg, and had a family history of hypertension. The following parameters were normal in nearly all patients: total erythrocyte Na+ and K+ concentrations, the maximal rate (Vmax) of inward cotransport, the affinity of cotransport with Rb+ as the substrate, the net outward cotransport of Na+ ions, the passive "leak" influx of Rb,+ and the maximal rate of Li+-Na+ countertransport. Only four patients gave clearly abnormal results; in two the maximal rate of both cotransport and countertransport was double the normal values, while another two patients demonstrated a greater than twofold increase in passive "leak" influx to Rb+ ions. Most of the patients with moderate to severe essential hypertension in this Australian study were characterized by normal erythrocyte cation fluxes, but a few showed elevation of both cotransport and countertransport of cations.

Adult↗