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Biomedical subjects

D A Cherry

Publications and source records attributed to D A Cherry.

28 records · Page 2Linked to original sources

The use of temporary atrial electrodes to improve diagnostic capabilities with Holter monitoring after cardiac surgery.

The use of temporary atrial electrodes implanted during cardiac surgery has been advocated for diagnosis and treatment of cardiac arrhythmias in the postoperative period. We have adapted this technique to allow continuous ambulatory electrocardiographic (Holter) recording of atrial activity in patients after coronary artery surgery. The electrodes of one of the two leads of the Holter recorder were attached as a surface electrocardiographic lead, while the electrodes of the other were each attached to one of the two implanted atrial wires. The Holter record was then obtained in the usual way. A satisfactory recording of the atrial electrocardiogram and the simultaneous surface electrocardiogram was obtained in all 6 patients and resulted in improved diagnostic capabilities, specifically in differentiating supraventricular and ventricular arrhythmia. As has proven to be true in the post-myocardial infarction setting, arrhythmias that were not noted clinically despite continuous electrocardiographic monitoring were demonstrated on Holter records.

Arrhythmias, Cardiac↗

A technique for the insertion of an implantable portal system for the long-term epidural administration of opioids in the treatment of cancer pain.

The feasibility of using a subcutaneously implanted portal system attached to a conventional 16-gauge epidural catheter has been evaluated in 50 patients with sever pain associated with cancer. This technique allowed for the percutaneous epidural administration of morphine at 8-12-hourly intervals for pain control. The mean duration of implantation was 12 weeks and the longest period a portal remained in situ was 36 weeks. Five portals had to be removed for various reasons. The injection system has blocked on eight occasions due to catheter blockage (six times) and portal blockage (two occasions). These patients have continued to obtain excellent analgesia when either catheter or portal were replaced. In a cadaver, 300 injections were simulated using either 22-gauge Huber point needles or disposable needles (25 gauge) and the injectate examined by both light and scanning electron microscopy. Both needle types resulted in particulate contamination which was greater with the recommended Huber point needles.

Analgesia↗

Analgesics.

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Analgesics↗

A technical aid to performance of neurolytic lumbar sympathectomy.

The injection of ten ml of air into the retroperitoneal space outlines the anterior margin of the psoas muscle. This been found to be useful, using an Image Intensifier, for the accurate location of needle tips in the performance of neurolytic lumbar sympathectomy.

Autonomic Nerve Block↗

Persistent atrial activity during cardioplegic arrest: suppression by verapamil.

Postoperative supraventricular tachyarrhythmia may occur more often in patients with persistent atrial activity during hyperkalemic hypothermic cardioplegic arrest. Cannulation of both venae cavae with simultaneous right atrial intra-cavitary cooling reduces atrial activity but is cumbersome. To evaluate pharmacologically-induced atrial arrest using verapamil, bipolar ventricular and right atrial electrograms were recorded in 12 dogs during one hour of hyperkalemic hypothermic cardioplegic arrest and cardiopulmonary bypass using single caval cannula. Group I (n = 6) received hyperkalemic hypothermic cardioplegic solution (4 degrees C) (20 mEq/1 K+) with verapamil (1 mg/L) by intermittent intra-aortic infusion during systemic hypothermia (28 degrees C). Group II (n = 6) received hyperkalemic hypothermic cardioplegia without verapamil. The percentage of time atrial activity was present (greater than 10 beats/min) in Group I, was significantly less than in Group II. Similarly the total number of atrial beats in Group I was less than in Group II. Recovery of normal sinus rhythm during reperfusion was prolonged in Group I in comparison to Group II. Verapamil induces significant and persistent atrial suppression during hyperkalemic hypothermic cardioplegic arrest but prolongs recovery of normal sinus rhythm during reperfusion. It remains to be established clinically whether verapamil-induced atrial suppression is associated with less postoperative supraventricular tachyarrhythmia. The potential disadvantage of prolonged sinus node recovery time must also be assessed.

Animals↗