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Biomedical subjects

D A Buchler

Publications and source records attributed to D A Buchler.

At least 37 records · Page 2Linked to original sources
PubMed1983

Colon carcinoma metastatic to the ovary.

We reviewed 17 patients with colon carcinoma metastatic to the ovary seen from 1970-1980. This represents 2.5% of the total malignant ovarian neoplasms seen during this time period. In 3/17 patients, exploratory celiotomy was performed without preoperative barium enema, stool for occult blood, or colonoscopy. These patients subsequently were found to have a primary colon carcinoma. Colectomy was performed in 8/17 of our patients without prophylactic oophorectomy. All of these patients subsequently developed metastatic ovarian carcinoma. Long-term survival in our series was dismal. We recommend (1) a compulsary colon examination to include colonoscopy prior to surgery for ovarian masses, and (2) prophylactic bilateral salphingo-oophorectomy at the time of colectomy for colon carcinoma.

Adult↗
PubMed1983

The structure and origin of giant nuclei in human cancer cells.

The structure and origin of giant nuclei in human cancer cells were studied in two cases of squamous cell carcinoma of the cervix. Feulgen-squash preparations of untreated biopsies showed the following types of nuclei: fairly evenly stained nuclei, nuclei with distinct chromocenters from which individual chromosomes sometimes seemed to radiate, and nuclei with banded structures which we tentatively interpret as some type of "polytene" chromosomes possibly showing prophase chromomeres. In neither tumor did either the small or large nuclei display any X chromatin bodies. The main processes giving rise to the different types of nuclei are endoreduplication, true endomitosis, and a kind of polytenization. The multichromosome chromocenters that fell apart possibly represent polytene chromosomes separating into individual chromosomes.

Biopsy↗
PubMed1982

Percutaneous lymph node aspiration in patients with gynecologic tumors.

Sixty-one patients with gynecologic malignancies had percutaneous transperitoneal lymph node aspiration performed by a flexible 8-inch needle guided to the nodes under monoplanar fluoroscopy. Of the patients who had malignant cells aspirated from pelvic and periaortic lymph nodes, 64% died or are alive with disease. Only 30% who had negative cytologic testing died or are alive with disease. Of the patients who had malignant cells aspirated from periaortic nodes, 69% died or are alive with disease whereas only 8% with negative cytologic testing died or are alive with disease. We believe that therapy such as extended field irradiation can be given on the basis of these results.

Aorta↗
PubMed1982

Neurotropic melanoma of the vulva.

A spindle cell melanoma of the clitoris was associated with a large area of lentiginous melanocytic dysplasia in the vulva of a 51-year-old woman. There was extensive neoplastic of the dermis, a desmoplastic reaction, and replacement of perineurial and Schwann cells by tumor cells (neurotropism). The superficial dysplastic components were pigmented, but melanosomes were not identified in a lymph node metastasis. Here the internuclear areas strongly resembled neuropil. Vulvar melanoma is rate, and this is the first report of neurotropic melanoma in this site.

Cell Nucleus↗
PubMed1979

Primary invasive squamous carcinoma of the vagina.

Forty-three cases of primary vaginal squamous cell cancer were treated at the University of Wisconsin Hospital between 1956 and 1971. These cases comprised 1.2% of patients admitted to the University Hospital with female genital tract cancer. Evidence is presented to support a modification of the currently accepted FIGO staging system for vaginal carcinoma (Stage II disease). Radiation therapy using both external beam and brachyradium equivalents or interstitial implantation of suitable isotopes was an effective method for the treatment of patients having early and locally advanced invasive vaginal cancer. The 5-year absolute survival rate for the entire series was 37.2%. Absolute survival rate by modified FIGO clinical staging was 66% for Stages I and IIA, 31% for Stage IIB, 25% for Stage III, and 0% for Stage IV.

Adult↗
PubMed1977

Carcinoma of vagina 10 or more years following pelvic irradiation therapy.

Gynecologic cancer records of 4,238 patients treated between 1956 and 1974 were reviewed. Sixteen patients developed noeplasia in the cervix or vagina 10 or more years following pelvic irradiation. Three patients had squamous carcinoma in situ; the other 13 patients had invasive squamous cancer involving the upper vagina. Only 1.26 per cent of invasive carcinoma of the cervix treated by radiation therapy from 1956 to 1966 presented with a late or recurrent or new primary tumor involving the vagina or cervix 10 or more years after primary treatment. The authors conclude that the risk of developing radiation-induced carcinoma in the upper vagina or cervix following pelvic irradiation is low. Follow-up Pap smears are indicated for all patients treated for cervical or vaginal malignancies by radiation therapy in order to detect vaginal neoplasia as well as recurrent carcinoma of the cervix.

Adult↗
PubMed1977

Stage III ovarian carcinoma: treatment and results. Comparison of multiple drugs, a single drug, and irradiation.

Multiple drugs, a single drug, and irradiation were compared in patients with Stage III ovarian carcinoma. The results were categorized as "favorable" [pelvic mass less than 8 cm and/or upper abdominal tumor nodule(s) less than 2 cm] or "unfavorable" (more massive disease). A total of 62 patients are reviewed of whom 25 had irradiation and 37 had chemotherapy. It was found that patients with slight residual disease after celiotomy did equally well with either irradiation or chemotherapy, but survival was improved using a combination of both. Use of 5 drugs did not significantly improve survival beyond that obtained with a single drug.

Drug Therapy, Combination↗
PubMed1977

Bipedal lymphangiography in malignancies of the uterine corpus.

Bipedal lymphangiography was performed in 116 selected patients with primary endometrial malignancy since 1970. A total of 32 were interpreted as positive and 84 as negative. Although histologic confirmation of nodal interpretation was seldom obtained, short term follow-up indicates that a positive interpretation is associated with an extremely poor prognosis. Lymphangiograms are recommended in all stage I patients except those with well differentiated histology, a small corpus, and no deep myometrial invasion. This study is also recommended for all stage II and III patients and for selected patients with stage IV disease.

Adenocarcinoma↗
PubMed1975

Multiple primaries and gynecologic malignancies.

An analysis was done on all gynecologic malignancies over a 13 year period to review the frequency and types of multiple primaries. A surprising spectrum of malignancy is seen and certain radiologic studies are of particular value. The time from occurrence of the various extragenital and genital tract cancers to the original gynecologic malignancy is shown. The per cent and types of malignancies that subsequently develop after a genital tract cancer are discussed.

Breast Neoplasms↗