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Biomedical subjects

D A Bell

Publications and source records attributed to D A Bell.

At least 235 records · Page 13Linked to original sources
PubMed1982

Factor VIII related antigen in adenomatoid tumors: implications for histogenesis.

The current study was undertaken to reevaluate the histogenesis of adenomatoid tumor by an immunoperoxidase method of detecting factor VIII related antigen, a tissue specific marker for vascular endothelium. Three of eight adenomatoid tumors showed diffuse cytoplasmic staining of the cells lining the lumina. When these results were correlated with the light and electron microscopy, it was found that there were two distinct groups of tumors. The vascular adenomatoid tumors stained positively for factor VIII related antigen and did not have tumor cells between tubules. The mesothelial adenomatoid tumor did not stain for factor VIII related antigen, had individual and solid nests of tumor cells between the tubules and had mesothelial characteristics on electron microscopy. These results strongly suggest that adenomatoid tumors can be subdivided into tumors of either mesothelial or vascular endothelial origin, and that these two groups can be distinguished on light microscopy.

Adenoma↗
PubMed1982

Pathologic predictors of recurrence in stage 1 (TINOMO) breast cancer.

A group of 122 consecutively treated pathologic Stage 1 (TINOMO) patients with cancer of the breast were studied to define histopathologic predictors of recurrence. Lymphatic invasion was the most significant predictor of recurrence; recurrence was present in 32% (8/25) of patients who had lymphatic invasion and in 10.3% (10/97) of patients who did not (P = 0.006). Histologic type was also predictive of recurrent disease. Eighteen per cent (18/101) of patients with invasive ductal or lobular carcinoma developed recurrent disease, while none of the group of 21 patients with medullary carcinoma, tubular carcinoma, colloid carcinoma, Paget's disease, and intraductal carcinoma with minimal invasion suffered a recurrence (P = 0.036). Vascular invasion, grade of malignancy, cellularity, presence or absence of circumscription, cellular infiltrate, fibroblastic response, neural invasion, and necrosis were not significant predictors of recurrence. Multiple logistic regression analysis of patients with invasive ductal or lobular carcinoma confirmed the results for individual factors, that only patients with lymphatic invasion were at higher risk of recurrence.

Breast Neoplasms↗
PubMed1981

Chronic relapsing pancreatitis in childhood.

A case of idiopathic, chronic relapsing pancreatitis arising in childhood is presented and compared with the 12 previously reported cases. This entity is a rare cause of severe, recurrent abdominal pain in childhood. The diagnosis is suggested by elevated serum or urine amylase values or pancreatic calcifications. Ultrasound, computerized tomography, or as in this case, endoscopic retrograde cholangiopancreatography can aid in the diagnosis. Surgery yields excellent results.

Adult↗
PubMed1981

Cardiac myxoma with chondroid features: a light and electron microscopic study.

The first case of a cardiac myxoma exhibiting chondroid differentiation is described. The tumor showed lacunar spaces around clusters of typical myxoma cells on light microscopy. Ultrastructurally the tumor cells contained abundant glycogen, and the tumor stroma contained proteoglycan granules identical to those seen in the ground substance of cartilage. These findings lend further support to the belief that the primitive mesenchymal cell is the cell of origin in cardiac myxoma.

Cartilage↗
PubMed1981

Leiomyosarcoma of the dartos muscle.

Smooth muscle is seen in the skin in three locations, the arrectores pilorum muscles, the wall of vessels and the specialized muscles in genital skin (the dartos, vulvar, and mamillary muscles of the scrotum, labia majora, and the breast, respectively). We report a case of a leiomyosarcoma of the dartos muscle in a 57-year-old man. The histological features of this tumor are similar to the previously reported cases of leiomyosarcomas of the skin thought to originate in arrectores pilorum muscles and the wall of vessels.

Genital Neoplasms, Male↗
PubMed1981

Immunogenicity and characterization of supernatant DNA released by murine spleen cells.

The cellfree supernatant from cultured splenocytes contains an immunogenic molecule capable of inducing anti-DNA antibodies in vitro and in vivo in young preautoimmune NZB/W and some normal mouse strains. The response to this supernatant material does not reflect polyclonal activation, and the molecule responsible for its immunogenic activity appears to be a relatively small (approximately 150 base pairs) DNA molecule, predominantly (75 to 80%) double stranded with tail-end single-strand regions. It does not appear to contain any unusual secondary structure. This immunogenic DNA molecule can be recovered from cultures of some normal as well as young B/W mice. It contains no observable protein moiety, and after phenol-chloroform extraction, the immunogenic DNA migrates on polyacrylamide and agarose gels as a relatively narrow homogeneous band. The anti-DNA antibody response detected in the serum of mice after injection of this DNA molecule appears to have its greatest affinity for the homologous DNA and for undenatured calf thymus DNA. Unique base sequences do not appear to be responsible for its immunogenic effects. Rather, this may depend on its relatively small size, since calf thymus DNA sheared to a similar size and also found incapable of digestion with restriction endonucleases had a similar immunogenic effect.

Animals↗
PubMed1980

Serologic subsets in systemic lupus erythematosus: an examination of autoantibodies in relationship to clinical features of disease and HLA antigens.

A search for anti-Ro or anti-nRNP antibodies by precipitin analysis among a population of 64 patients with systemic lupus erythematosus (SLE) or mixed connective tissue disease was undertaken. The 25% of SLE patients with anti-Ro did not have any distinct clinical features, compared to patients without anti-Ro or to anti-nRNP patients with SLE or mixed connective tissue disease. However, these patients did have a significantly greater frequency of rheumatoid factor (80%). Most importantly however, patients with anti-Ro had a significantly increased frequency of HLA-B8 (81%) and HLA-DRw3 (100%) compared to patients with anti-nRNP (B8--29%; DRw3--33%) or SLE patients without such antibodies (B8--41%; DRw3--25%). These data suggest the existence of a specific immune response gene for Ro close to the D region of the major histocompatibility complex.

Adult↗
PubMed1980

Induction of anti-ssDNA antibodies in normal and preautoimmune mice in vivo.

Splenic lymphoid cells of normal and preautoimmune mice escape normal regulatory mechanisms in vitro and spontaneously synthesize anti-ssDNA antibody in the absence of any exogenous antigen. In addition, both the cultured cells and their cell-free supernatants were capable of inducing specific anti-ssDNA responses in vivo upon their injection into syngeneic recipients. The response was host-derived, required the participation of B and T cells, and was not due to polyclonal activation. The immunogen responsible for this response appeared to be membrane-associated, was found predominantly on cultured T cells, and was sensitive to DNase and proteolysis.

Animals↗
PubMed1980

Tubular carcinoma and sclerosing adenosis: the use of basal lamina as a differential feature.

Recent ultrastructural studies have shown that tubular carcinoma of the breast lacks basal lamina. This study was undertaken to determine the usefulness of light-microscopic examination of PAS staining for basal lamina in the differentiation of tubular carcinoma and sclerosing adenosis. Ten cases of tubular carcinoma show no basal lamina except for an occasional short segment. Ten cases of sclerosing adenosis show intact basal lamina except for short focal discontinuities. It is concluded that the lack of basal lamina in tubular carcinoma and its presence in sclerosing adenosis is a useful differential feature.

Adenocarcinoma↗
PubMed1980

Benign cystic teratoma in the omentum: a mechanism of its development.

Benign cystic teratoma rarely occurs in the omentum. The pathogenesis of the occurrence of this tumor in the omentum is unclear. A case of this entity is presented in which the pathological findings indicate that the omental benign cystic teratoma detached from the left ovary, leaving only a small portion of residual ovary in the left adnexa. Additional findings in this case were a ventral hernia, intra-abdominal adhesions, a second benign cystic teratoma in the right ovary, and a ruptured mucocele of the appendix. The unusual coexistence of these lesions led to the erroneous impression at operation that the omental tumor represented metastatic carcinoma.

Dermoid Cyst↗
PubMed1978

Familial lupus. Family studies of HLA and serologic findings.

HLA profiles in 103 members of 4 separate kindred with multiple occurrence of SLE were compatible with the presence of a disease susceptibility factor linked to HLA or a direct effect of antigens B8, A11, and B35 on disease expression. Serum ANA was found in 52.9% of consanguineous, 56.5% of nonconsanguineous relatives of SLE probands, and 5% of controls, a finding that suggests the presence of a transmissible agent in the families. By contrast, lymphocytotoxic antibodies were not increased in relatives compared to controls.

Adolescent↗
PubMed1978

Alzheimer's disease and HLA.

Thrity-four unrelated patients with Alzheimer's disease were typed for HLA-A, -B and -C serological determinants. HLA-Cw3 was increased over control antigen frequencies. This difference lost significance when corrected for the number of antigens tested.

Alzheimer Disease↗
PubMed1978

Antibody to extractable nuclear antigen in the rheumatic diseases.

Two hundred and eighty-four patients with various rheumatic diseases were studied for the prevalence of antibodies to extractable nuclear antigen (anti-ENA) using an improved haemagglutination technique. Anti-ENA rarely occurred in patients with rheumatoid arthritis, scleroderma, polymyositis, dermatomyositis and Sjögren's syndrome. Seventeen per cent (13/72) of patients fulfilling at least four preliminary ARA criteria for systemic lupus erythematosus (SLE) demonstrated anti-ENA. The predominant antibody was directed at ribo-nuclease-resistant ENA (anti-Sm). Antibodies to ribo-nuclease-sensitive ENA (anti-RNP) occurred in the minority of patients with SLE (2/72) and the mixed connective tissue disease syndrome (MCTD). A trend toward an increased incidence of renal disease in SLE patients with anti-Sm was present. Sequential analysis of anti-Sm in patients with SLE showed a fall in titre paralleling the normalization of anti-DNA antibody titres and serum complement values. No case of unrecognized MCTD was uncovered in our rheumatic disease population.

Adult↗
PubMed1978

The occurrence of systemic lupus erythematosus in two kindreds in association with selective IGA deficiency.

The families of two patients with SLE and IgA deficiency were examined. A study of the first patient's family revealed that IgA deficiency was determined by an incompletely penetrant autosomal dominant gene not linked to the HLA locus. Antinuclear antibodies, found in consanguineous and nonconsanguineous relatives were not related to the presence of IgA deficiency or any HLA haplotype. The second patient and his father with antinuclear, anti RBC, and antithyroid auto-antibodies shared an HLA haplotype not present in other sibs. IgA deficiency was not inherited in this family but may have influenced the expression of disease in the propositus or could have resulted from the disease itself.

Adolescent↗