Biomedical subjects

Corina Dima Cozma

Publications and source records attributed to Corina Dima Cozma.

3 recordsLinked to original sources

PubMedDate not supplied

[The effects of the physical training on the hypertensive patients with glycoregulation disorder].

UNLABELLED: The purpose of our clinical study was the evaluation of moderate physical training on hypertensive patients with the impaired glycoregulation, for a determinate period of time. METHODS: The study included 80 patients with moderate hypertension, divided in two groups: group B formed of 40 patients that followed an associated treatment (physical exercises 3-5 times/week, 45-60 min. for one training and antihypertensive drug therapy) and group C formed of 40 patients that followed only drug therapy for controlling blood pressure. The glycoregulation disorder was appreciated by determining a jeune glycemia to all the patients, the oral glucose tolerance test at the patients who were until 60 years old and for which there wasn't any evidence of glucose intolerance a jeune. The uniform pattern of OGTT values was considered due to insulin resistance and hyperinsulinism. We obtained the values of cholesterol, triglycerides, HDL-C, LDL-C and atherogenesis index. RESULTS: The patients with impaired glycoregulation had significant increased values of cholesterol (p = 0.03) and triglycerides (p < 0.001), decreased HDL-C (p = 0.004), compared to the patients without glycoregulation disorder. LDL-C didn't vary significantly (p = 0.2). The patients with impaired glycoregulation had the value of ventricular mass 254.46 +/- 38 g, compared to 239.52 +/- 41 g for the patients without glycoregulation disorder. In group B, we found 14 patients with impaired glycoregulation (35%) and 11 patients in group C (27.5%) with the same metabolic disorder. After 6 month, only 9 patients with glycoregulation disorder (22.5) were left in group B and also 10 patients (25%) with the same disorder in group C. CONCLUSION: Moderate physical exercise associated with antihypertensive therapy induced, besides the decrease of blood pressure values, a good control of lipids and glucose markers of metabolism.

Antihypertensive Agents↗

PubMedDate not supplied

[Left cardiac dysfunction in COPD].

The study of evaluation and rehabilitation of COPD patient (SERBOC) started in January 2004 in the 6th Medical Clinic of the Iaşi Rehabilitation Hospital. One of its goals is to evaluate the left cardiac morphology and function in the chronic obstructive pulmonary disease. The inn-patients have been complexly approached by physical examination, chest X-ray, rest electrocardiogram, echocardiography and Holter monitoring. The stage result is that physical examination, chest X-ray and rest electrocardiogram fails in offering satisfactory information regarding left cardiac dysfunction; it is necessary to add Holter monitoring and especially echocardiography. The conventional and Doppler echocardiography performed in our clinic allowed the possibility to identify diastolic dysfunction in all 9 patients and systolic dysfunction in 7 of them.

Aged↗

PubMedDate not supplied

[The influence of intermediate physical training on some non-enzyme antioxidants of oxidative stress, in moderate hypertension].

A group of patients with moderate hypertension (149-150/90-99 mm Hg) performed physical exercise for 3 months; we determined the oxidative stress in blood samples, by calculating the level of some biochemical markers, non-enzyme antioxidants, glutathione (GSH), total -SH groups (G-STH), nonprotein -SH groups (G-SHNP), their G-SHT/G-SHNP ratio, uric acid, malondialdehyde (MDA) and comparing the results with the values obtained from a group of healthy subjects. We found an increased oxidative stress at the HTA patients, with initial (Vi) decreasing values of GSH and uric acid, and with higher values of MDA. After the 3 months (Vf) of physical training, the oxidative stress improved, with increasing GSH, uric acid and decreasing MDA, compared to normal subjects. The initial values of G-SHT, G-SHNP and their ratio, increased, but decreased after 3 months, with an inverse aspect to GSH. The clinical study proved that after 3 months of physical exercise, there wasn't any increased oxidative stress at the HTA patients; however, the oxidative stress is present, proved by the values of MDA, significantly higher compared to the normal subjects.

Antioxidants↗