Biomedical subjects

Chunling Yang

Publications and source records attributed to Chunling Yang.

3 recordsLinked to original sources

PubMed2006

Global impact: elucidating plant responses to viral infection.

Viruses induce a variety of responses in host cells that are mediated by perturbation of different signaling pathways. Advances in our understanding of the functions of viral proteins, plant biology in general, as well as technologies for profiling gene expression have converged in recent years to provide new insight into the events occurring inside susceptible and resistant host cells in response to virus infection. These effects range from nonspecific changes in gene expression due to the general accumulation of viral proteins to those responses that are initiated by the specific interactions between virus and host proteins. Here, we discuss a variety of expression profiling methods and approaches that have been used to study the effects of viruses on host transcriptomes. These studies have identified distinct sets of genes that have altered expression profiles in response to viruses, including stress- and defense-related genes. The activities of viral RNA silencing suppressors and interference with hormone signaling or biogenesis also influence plant gene expression and lead to developmental abnormalities.

Gene Expression Profiling↗

PubMed2006

Study on modeling of multispectral emissivity and optimization algorithm.

Target's spectral emissivity changes variously, and how to obtain target's continuous spectral emissivity is a difficult problem to be well solved nowadays. In this letter, an activation-function-tunable neural network is established, and a multistep searching method which can be used to train the model is proposed. The proposed method can effectively calculate the object's continuous spectral emissivity from the multispectral radiation information. It is a universal method, which can be used to realize on-line emissivity demarcation.

Letter↗

PubMed2003

Novel mutations in the IRF6 gene for Van der Woude syndrome.

Van der Woude syndrome (VWS, OMIM 119300) is an autosomal dominant craniofacial disorder characterized by pits of the lower lip, hypodontia, and cleft lip and/or cleft palate. It is the most common form of syndromic orofacial clefting and has very high penetrance with varied expressivity. The disease locus for VWS has been mapped to a 1.6-cM region on 1q32-41 between D1S205 and D1S491. Recently, mutations have been found in the interferon regulatory factor 6 ( IRF6) gene in patients with VWS and popliteal pterygium syndrome. To identify novel mutations of IRF6 in VWS patients, we screened four Chinese VWS families in all nine exons and their flanking splice junctions by direct sequencing. We identified three missense mutations and one nonsense mutation in IRF6. Our study further confirmed that IRF6 is essential for craniofacial development.

Base Sequence↗