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Chung-Yau Lo

Publications and source records attributed to Chung-Yau Lo.

6 recordsLinked to original sources
PubMed2002

Well-differentiated thyroid carcinoma in Hong Kong Chinese patients under 21 years of age: a 35-year experience.

BACKGROUND: Sporadic well-differentiated thyroid cancer is an uncommon condition in children, adolescents, and young adults. It is associated with distinct clinicopathologic features and prognosis. The present study reviews our experience in management of this condition in ethnic Chinese in Hong Kong. STUDY DESIGN: A retrospective study was performed to review the clinicopathologic features and outcomes of 34 patients less than 21 years of age with well-differentiated thyroid carcinoma over a 35-year period. Median followup was 15.2 years (range 1 to 32.5 years). RESULTS: There were 27 girls and 7 boys with a median age of 19 years (range 10 to 21 years). None had previous history of irradiation. Twenty-eight patients had papillary and six had follicular carcinomas. Operative procedures included total thyroidectomy (n = 27) and unilateral lobectomy (n = 7) with concomitant neck dissection performed in nine patients. The median tumor size was 2 cm and extrathyroidal invasion was present in 19 tumors. Adjuvant radioactive iodine treatment was administered to 18 patients after total thyroidectomy. Disease progression or recurrence rate was 24% and 27% at 5 and 10 years, respectively. The presence of lymph node metastases was associated with a higher incidence of disease recurrence. One patient with advanced local disease died from tumor bed recurrence with anaplastic transformation 18 years after the initial operation. CONCLUSIONS: Well-differentiated thyroid carcinoma is a relatively indolent tumor associated with good prognosis in young patients. Although death from this condition is rare, recurrence is frequent and longterm followup is necessary.

Adenocarcinoma, Follicular↗
PubMed2002

Parathyroid autotransplantation during thyroidectomy.

Permanent hypoparathyroidism is a debilitating morbidity following thyroidectomy, with a reported incidence of up to 43%. Apart from meticulous dissection to preserve parathyroid glands and their blood supply, parathyroid autotransplantation (PA) has been increasingly employed to preserve parathyroid function. The adoption of PA during thyroidectomy has been reported to be associated with a low incidence of permanent hypoparathyroidism. Biochemical function of parathyroid autografts can be demonstrated objectively by forearm reimplantation or during long-term follow up. The clearest indication for PA is for inadvertently removed or devascularized parathyroid glands during thyroid surgery. Other strategies, including routine autotransplantation of at least one parathyroid gland, can be considered, but is associated with a high incidence of transient hypocalcaemia. Apart from refinement in technique to facilitate graft success, a reliable way to assess overall parathyroid function or viability of individual parathyroid gland may assist in monitoring parathyroid function and selecting patients requiring this procedure to prevent permanent hypoparathyroidism.

Calcium↗
PubMed1999

The Clinicopathologic Significance of Unilateral Adrenal Cortical Hyperplasia: Report of an Unusual Case and a Review of the Literature.

We report a case of unilateral primary adrenal cortical hyperplasia associated with hyperaldosteromsm in a 39-yr-old Chinese man. The patient presented with hypertension hy pokalemia, primary hyperaldosteronism(1) suppressed renin activity, and was complicated with aortic dissection. The aortic dissection required emergency realignment while unilateral laparoscopic adrenalectomy was performed subsequently Pathologic examination of the adrenal lesion revealed multiple cortical nodules (up to 1 4 cm in diameter). No telomerase activity was detected in the adrenal lesion. A review of the literature showed that unilateral adrenal cortical hyperplasia has a predilection for the left side occurring more often in males. We conclude that unilateral adrenal cortical hyperplasia is a rare but unique entity and that unilateral adrenalectomy is the treatment of choice.

Journal Article↗
PubMed1999

Composite Pheochromocytoma-Ganglioneuroma of the Adrenal Gland: An Uncommon Entity with Distinctive Clinicopathologic Features.

Background: Adrenal composite pheochromocytoma-ganglioneuroma is uncommon. The aim of this study is to investigate the characteristics of patients with this tumor. Methods: Histologic features of 46 pheochromocytomas diagnosed over a 28-year period (1971-1998) were reviewed. The clinical records, pathologic features, and ploidy patterns of patients with composite pheochromocytoma-ganglioneuroma were studied. Cases reported in the literature were also reviewed and compared with typical pheochromocytomas. Results: Four patients (two men; two women) with composite pheochromocytoma-ganglioneuromas were found. The tumors comprised 8.7% of pheochromocytomas. The two male patients with composite tumors were younger than the two female patients (age = 32, 52 vs 73, 75, respectively). The radiologic, gross, and microscopic appearances of the tumors were heterogeneous. One patient had malignant tumor with distant metastases. Flow cytometric analysis showed that the pheochromocytoma component was aneuploid and the ganglioneuroma portion was diploid. A review of the literature showed 31 adrenal composite pheochromocytoma-ganglioneuromas. Composite tumors were seen in older patients and were bigger than typical pheochromocytomas. Conclusion: Composite pheochromocytoma-ganglioneuromas had distinctive clinicopathologic features. Life-long clinical and biochemical follow-up of these patients is essential in view of the non-diploid DNA pattern.

Journal Article↗