Biomedical subjects

Christopher G Eden

Publications and source records attributed to Christopher G Eden.

7 recordsLinked to original sources

PubMed2006

The impact of obesity on laparoscopic radical prostatectomy.

OBJECTIVE: To investigate the effect of obesity on the operative variables of patients undergoing laparoscopic radical prostatectomy (LRP). PATIENTS AND METHODS: The database entries and case-notes of 532 consecutive patients undergoing LRP from March 2000 to August 2005 were examined retrospectively. Complete data were available on 505 (95%) patients, 108 (21%) of whom were obese (body mass index, BMI, > or = 30 kg/m2). All patients had clinical stage T < or = 3aN0M0 prostate cancer and had their procedure done or supervised by the same surgeon. RESULTS: The patients' prostate-specific antigen level, Gleason score, clinical stage and prostate weight were similar. The mean values for patients deemed not obese and obese were: for operative duration (182 and 197 min, P = 0.01), blood loss (310 and 250 mL, P = 0.66), hospital stay (3.0 and 3.3 nights, P = 1.00), complications (3.5% and 4.6%, P = 0.77), positive margins (15.4% and 20.6%, P = 0.26) and biochemical recurrence (3.8% and 3.7%, P = 1.00) at a mean follow-up of 9.7 and 12.0 months, respectively. CONCLUSION: The operation was significantly longer for obese patients, by a mean of 15 min; all other variables were comparable in the two groups. The results from this study suggest that obese patients can expect a similar outcome to their non-obese counterparts after LRP, when operated on by an experienced surgeon.

Adenocarcinoma↗

PubMed2006

Laparoscopic radical prostatectomy: minimum 3-year follow-up of the first 100 patients in the UK.

OBJECTIVE: To present the results of the first 100 patients in the UK treated by laparoscopic radical prostatectomy (LRP) and with at least 3 years of follow-up, as LRP continues to develop as a minimally invasive alternative to open radical prostatectomy. PATIENTS AND METHODS: In all, 100 patients (mean age 62 years, range 52-72) had a transperitoneal LRP by one surgeon during a 25-month period from 2000 to 2002. Most (78%) patients had a prostate-specific antigen level of 4-10 ng/mL, clinical stage T1 disease (62%), and Gleason 6 on biopsy (50%). Sixty-four patients had unilateral or bilateral nerve preservation and 14 had pelvic lymphadenectomy. RESULTS: The mean operative duration was 245 min, with a 1% conversion rate. Three patients received a blood transfusion and three had major complications, including a rectal injury. The positive margin rate was 16% and correlated with pathological variables. At > or = 3 years of follow-up (mean 3.7) the overall survival rate was 99% and the biochemical progression-free survival was 88% in all patients, at 90% for pT2 and 75% for pT3. Ninety patients used 0-1 pads/day (84% pad-free) and 60 undergoing nerve preservation retained erectile function. CONCLUSION: This series includes the first results for LRP with a > or = 3-year follow-up reported from the UK, with oncological control and morbidity comparable to those in previously published open and laparoscopic series. The history of open radical prostatectomy suggests that as the technique of LRP develops and experience with it increases, these results are likely to improve.

Aged↗

PubMed2006