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Biomedical subjects

Christof Radler

Publications and source records attributed to Christof Radler.

5 recordsLinked to original sources

Dysplasia of the cruciate ligaments: radiographic assessment and classification.

BACKGROUND: A common pathologic finding in the knee associated with congenital longitudinal deformity is aplasia of one or both cruciate ligaments. We performed a radiographic analysis to assess the changes in the femoral intercondylar notch and the tibial eminence in relation to the status of the cruciate ligaments. METHODS: Thirty-four knees in thirty-one patients with longitudinal congenital deficiency of the lower limb were evaluated. The cruciate ligaments and the associated abnormalities of the distal aspect of the femur and the proximal aspect of the tibia were evaluated with use of magnetic resonance imaging and a tunnel view radiograph. RESULTS: We differentiated three main types of dysplasia of the cruciate ligaments with typical associated changes. In type I, partial closure of the femoral intercondylar notch and hypoplasia of the tibial eminence are observed and the anterior cruciate ligament is hypoplastic or aplastic. In type II, these findings are accentuated and there is additional hypoplasia of the posterior cruciate ligament. In type III, the femoral intercondylar notch and the tibial eminence are completely absent and there is aplasia of both cruciate ligaments. CONCLUSIONS: We delineated three types of congenital deficiency of the cruciate ligaments and found corresponding morphologic changes of the femoral notch and the tibial eminence, which can be observed on tunnel view radiographs. Thus, the diagnosis and differentiation between aplasia of one or both cruciate ligaments and between congenital and trauma-induced absence of the cruciate ligaments may be made by interpreting plain radiographs.

Adolescent↗

Treatment options for developmental dislocation of the hip after walking age.

Cases of developmental dislocation of the hip occur after walking age because of late or missed diagnosis and failed conservative or operative treatment. Although a general consensus exists for the treatment in infants up to the age of 18 months, the recommendations for the treatment of developmental dislocation of the hip in older children range from conservative treatment up to 3 years of age to primary surgical procedures from the age of 18 months. A review of the pertinent literature and of the different treatment options was performed and the authors' preferred treatment regime and techniques for the operative treatment of developmental dislocation of the hip after walking age are reported.

Adolescent↗

Pharmacological management of aseptic osteonecrosis in children.

Aseptic osteonecrosis (AON) in children can progress during ossification of cartilage in periods of increased growth or excessive physical stain and may occur in various locations in the skeleton. Disturbance of blood supply to the bone has been suggested as the main pathological mechanism involved in AON, which is characterised by the death of bone marrow and trabecular bone. The extent and development of osteonecrosis and the duration of disease until restorative healing, depend on the formation of new blood vessels, the spreading of vessels in the affected bony areas, the absorption of osteonecrotic tissue and the structure of new bone. Conservative and operative treatment options for AON vary according to the location and development of the disease and the age of the patient. The goal of all treatment options currently used today is to achieve relief of physical load in the affected bone and to promote and regulate blood supply. Treatment should be started early in order to minimise the extent of osteonecrosis and allow restorative healing. As the processes of myelopoiesis, myelophthisis and fracture healing become more clear, interest has focused on advances in the utilisation of bioactive factors to salvage bone in children affected by AON. Such methods include the use of osteoinductive agents, such as cytokines and bone morphogenetic proteins, as well as factors that stimulate angiogenesis and regulate blood supply. Currently, the prostacyclin analogue, iloprost (Ilomedin, Schering AG), has been successfully used in a pilot study in children suffering from early stages of AON.

Child↗

Ponseti versus traditional methods of casting for idiopathic clubfoot.

Serial casting is successful in avoiding extensive posteromedial release (PMR) in only 11% to 58% of patients with idiopathic congenital clubfoot. Extensive open surgery is commonly associated with long-term stiffness and weakness. Ponseti claims to avoid PMR in 89% of cases by using his specific technique of manipulation, casting, and limited surgery. The authors report their first 27 patients undergoing the Ponseti technique (34 feet) with a group of 27 matched control patients (34 feet). All patients underwent serial casting, begun within the first 3 months of life. The parameter studied was the need to perform PMR within the first year of life. In the Ponseti group, only 1 (3%) of 34 feet required PMR. In 31 (91%) of 34 feet, percutaneous Achilles tenotomy was performed at age 2 to 3 months. The average duration of casting was 2 months. In the control group, 32 (94%) of 34 feet required PMR within the first year of life, despite a longer casting period. Based on the authors' initial success with the Ponseti method, they no longer believe that PMR is required for most cases of idiopathic clubfoot. Foot abduction splints are crucial to avoid recurrence. Longer follow-up will determine whether the authors can continue to match Ponseti's reported outcomes.

Case-Control Studies↗