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Biomedical subjects

Christian von Buchwald

Publications and source records attributed to Christian von Buchwald.

6 recordsLinked to original sources

[An extensive case of maxillary pneumosinus dilatans].

We present a 40-year-old male with an aggressive case of maxillary pneumosinus dilatans. Our examination including rhinoscopy showed that the nasal wall including the middle turbinate was displaced towards the nasal septum obliterating the middle meatus. A reopening of the affected maxillary sinus was performed endoscopically with success. At the follow-up examination and exposure to high altitude simulation in an underpressure chamber 15 months postoperatively the patient had no symptoms and there were no signs of exopthalmus or facial swelling.

Adult↗

[Sentinel node biopsy in head and neck cancer. Is there an indication for use of this new surgical technique in the treatment of head and neck cancer?].

Management of the clinically N0 neck in head and neck squamous cell carcinoma remains controversial. Since lymph node metastasis reduces the five-year survival by up till 50%, the need for an accurate diagnostic procedure is necessary. The sentinel node, being the initial lymph node to which the primary tumour drains, is believed to be invaded by early metastasis. Identification of the sentinel node by means of a dye or isotope or a combination, and surgical removal followed by histological examination verifies the involvement of the regional glands. At present few and limited materials on head and neck cancers exist, primarily on oral and oropharyngeal cancers. The techniques used are various and not without difficulties. To evaluate the feasibility of the sentinel node biopsy in head and neck cancer, it is proposed to perform a nationwide cohort study that comprises all minor oral and oropharyngeal cancers (T1, T2, N0).

Carcinoma, Squamous Cell↗

[Oral focal epithelial hyperplasia. Any risk of confusion with oral condylomas?].

INTRODUCTION: Focal epithelial hyperplasia (FEH) is a disease of the oral mucosa caused by human papilloma virus (HPV) types 13 and 32. It is not very common in Denmark and thus not well known to most physicians. It is rarely seen in Caucasians, but in other parts of the world, especially in the southeast Mediterranean countries, among the native Indians of South and Central America, and in Eskimos the disease is rather common. FEH presents with exophytic lesions of the oral mucosa and may be rather easily confused with papillomas or condylomas, and therefore perhaps give rise to the suspicion of sexual abuse in children. We describe easy ways of making an accurate diagnosis of FEH and other HPV-related diseases. MATERIAL AND METHODS: We present five patients who were diagnosed with FEH by in situ hybridisation on biopsies or by conducting PCR with HPV type-specific consensus primers followed by analysis of the restriction fragment length polymorphism. RESULTS: FEH could be diagnosed in all five patients by the two procedures described. In three cases, both methods were applied and gave identical results. Three patients were infected with HPV type 32 and two patients with HPV type 13. Co-infection with more than one HPV type was not found. DISCUSSION: Many physicians rarely encounter FEH, and will thus have difficulty in reaching an accurate diagnosis. In doubtful cases, oral papillomatous or exophytic lesions should be subjected to HPV typing. When suspicion of oral condylomas is raised, particularly in children, accurate diagnosis is necessary to rule out suspected sexual abuse. Viral DNA for HPV typing can be easily obtained, simply by scraping the lesion.

Adolescent↗

Sentinel node biopsy: the technique and the feasibility in head and neck cancer.

Management of the clinically N(0) neck in head and neck squamous cell carcinoma is still under debate. Tumour spread to the neck is the most important prognostic factor in head and neck cancer patients. The sentinel node technique comprises the identification of the sentinel node by means of dye or isotope or a combination, and surgical removal followed by histological examination. We have reviewed the preliminary reports indicating that sentinel node identification is technically feasible in head and neck cancer surgery, i.e. in solitary and unilaterally oral and pharyngeal cancer stages T1 and T2 with clinical N(0). However, the existing reports enrole observational studies, thus randomised trials should be considered to gain maximum valid data to prove that sentinel node biopsy has an effect on parameters such as loco-regional control and survival.

Carcinoma, Squamous Cell↗

Unexpected expansive paranasal sinus mucormycosis.

Mucormycosis infection of the paranasal sinuses is a very rare but serious condition. Patients are usually immunocompromised by systemic disease. We report an unexpected case of expansive paranasal sinus mucormycosis in an immunocompetent European treated successfully with surgical debridement and intravenous amphotericin B. The pathogenesis, diagnosis and treatment of paranasal sinus mucormycosis is discussed.

Anti-Bacterial Agents↗