Biomedical subjects

Chiaki Tanaka

Publications and source records attributed to Chiaki Tanaka.

3 recordsLinked to original sources

PubMed2003

Hip dysplasia in Charcot-Marie-Tooth disease: report of a family.

Charcot-Marie-Tooth disease is classified into hereditary motor and sensory neuropathy (HMSN) types I and II, and affected patients present with progressive peripheral neuropathy. Some previous orthopedic studies have revealed the association of hip dysplasia with HMSN, in addition to pes cavovarus, scoliosis, and recurrent dislocation of the patella. We describe three patients from the same family who were each diagnosed as having HMSN type I with associated bilateral severe hip dysplasia, borderline abnormalities of both acetabula, and dysplastic osteoarthritis. Based on our experience with these patients and a review of previous reports, we concluded that routine screening of hip joints, especially for those with a family history of HMSN, is necessary for early diagnosis.

Adult↗

PubMed2002

Reference method for platelet enumeration.

The main principle of enumerating platelets in automated hematology analyzer is electric resistance system. However, there have been an increasing number of instruments that can enumerate platelets by optical system. The use of a flow cytometry (FCM) employing monoclonal antibody has been under study for the enumeration of platelets in recent years. At its meeting held in April 2000, the International Society for Laboratory Hematology (ISLH) decided on a protocol to study the possibility of using, as reference method, a monoclonal antibody-employed FCM of enumerating platelets. In our present study, we obtained platelet count by the monoclonal antibody-employed method proposed by ISLH, and compared the result with platelet count obtained with an automated hematology analyzer XE-2100 (Standard counter at Scientific Division, Sysmex, Kobe, Japan) employing electric resistance system, and another platelet count obtained by optical system.

Antibodies, Monoclonal↗

PubMedDate not supplied

Extension of breast cancer: comparison of CT and MRI.

PURPOSE: To compare three-dimensional (3D) helical CT with 3D MRI in the evaluation of intraductal spread of breast cancer. METHODS: Fifty patients with breast cancer were examined. Tumor size ranged from Tis to T2. The whole breast was scanned by both breath-holding helical CT and MRI with contrast media. Linear or segmental enhancement, and spotty enhancement around the main tumor were considered to indicate ductal carcinoma in situ (DCIS) or ductal spread. These findings were compared with thin section histopathologic data. RESULTS: Seventeen of 35 patients had intraductal spread with invasive cancer and 15 patients had DCIS. The sensitivity, specificity, and accuracy of 3D CT in detecting intraductal spread or DCIS were 71.9%, 83.3%, and 76.0%, respectively, and those of 3D MRI were 87.5%, 61.1%, and 78.0%. Overestimations numbered three (6.0%) on CT and seven (14.0%) on MRI, and underestimations numbered nine (18.0%) on CT and four (8.0%) on MRI. CONCLUSION: 3D helical CT can provide good information about the spread of breast cancer and could be an alternative to 3D MRI for preoperative examination of breast cancer.

Adult↗