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Biomedical subjects

Ch Meyenberger

Publications and source records attributed to Ch Meyenberger.

5 recordsLinked to original sources

[Helicobacter pylori 2006: how to test, when to treat].

The role of Helicobacter pylori in peptic-disease, gastric adeno-carcinoma and the MALT- lymphoma is established. The H. pylori diagnostics and the eradication therapy are highly disputed in patients with dyspepsia. An endoscopy is recommended to patients older than 45 who have dyspeptic disorders. Non-invasive testing and treatment is an adequate option to those patients younger than 45, if no alarm symptoms exist. The H.pylori serology, the 13C- breath test and the stool-antigen test have proven to be the best in laboratory testing. The therapeutic regimen of H. pylori eradication consists of a proton pump inhibitor (PPI) and two antibiotics, though it isn't always successful. After a second treatment failure, a H. pylori culture is indicated to asses the antibiotic resistances.

Adenocarcinoma↗

[Does the ultrasound make the clinical examination of the abdomen unnecessary?].

The clinical examination holds an important significance in today's medical way of life. Especially in Gastroenterology, the conversation including a meticulous anamnesis, the observation of a patient and the physical examination are the key to diagnosing a multitude of diseases. And are also indispensable for a sensible and purposeful use of all of today's available technical resources.

Abdomen↗

[Non-healing gastric ulcer].

HISTORY AND ADMISSION FINDINGS: A 47-year-old Angolan complained of upper abdominal pain, fever, weight loss and night sweats. Abdominal ultrasound performed by his general practitioner showed enlarged lymph nodes at the liver hilum. Physical examination was negative except for slight tenderness over the right upper abdomen. INVESTIGATIONS: A tuberculin skin test was clearly positive. Upper gastrointestinal endoscopy revealed multiple gastric ulcers and the Helicobacter pylori test was positive. The lymph nodes at the liver hilum were needle-aspirated, this showed granulomatous inflammation similar to the biopsies of the ulcers. Eradication of Helicobacter pylori and therapy with proton pump inhibitors were initiated. DIAGNOSIS, TREATMENT AND COURSE: Epigastric pain and the ulcers persisted unchanged. The culture of the lymph node aspirate grew multiresistent Mycobacterium tuberculosis. With adequate tuberculostatic therapy the patient improved rapidly and the further course was without any complications. CONCLUSION: Tuberculosis should be included in the differential diagnosis in non-healing ulcers of the gastrointestinal tract, especially in immigrants from endemic areas.

Biopsy, Needle↗

[Biliary stents].

Endoscopically implantable stents are today the mainstay for therapy of biliary stenoses. It is important to know if a benign or a malignant stenosis is the cause of the biliary obstruction. Generally benign stenoses are treated with plastic-stents whereas malignant stenoses are managed by implantation of a metallic stent. The main indications for plastic stents are postoperative strictures in the biliary tree for example, after biliary tract surgery or liver transplantation, primary sclerosing cholangitis and postoperative biliary leakage. Metallic stents are implanted in palliative circumstances like in stenosing cholangiocarcinoma or in situations where a hepatic metastasis exerts an extrinsic compression on the biliary tract with consecutive cholestasis. The materials used for manufacturing both stent types are biologically inert and thus biocompatible. A current poorly resolved problem is the occlusion of the stent lumen (by sludge, bacterial degradation products etc.) which occurs in both stent types with time. These problems lead to stentocclusion around three to six months after implantation and necessitate endoscopical re-interventions in order to overcome the occlusion. The patency rate for metallic stents is better than for plastic ones. The endoscopic stenttherapy is equivalent to surgical therapy (Intestinal bypass-procedures).

Bile Duct Neoplasms↗