Keys to unlock cancer: targeted therapy.
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Antibodies, Monoclonal↗
Biomedical subjects
Carol S Viele
Publications and source records attributed to Carol S Viele.
Normal clotting.
OBJECTIVE: To review the normal coagulation process and the mechanisms that lead to abnormal clotting. DATA SOURCES: Primary and tertiary literature and the authors' clinical experience. CONCLUSION: The process of coagulation is complex and can be easily misunderstood. It is important to be familiar with normal coagulation before one can comprehend the coagulopathies associated with malignancies. IMPLICATIONS FOR NURSING PRACTICE: A thorough understanding of the coagulation process is a critical prerequisite to caring for patients with clotting disorders. Once the normal clotting process is understood, the abnormal becomes easier to recognize and the cancer-associated dysfunctions more readily identified.
Blood Coagulation↗
Diagnosis, treatment, and nursing care of acute leukemia.
OBJECTIVE: To review the clinical presentation, current methods of diagnosis and classification, treatment modalities, and novel treatment approaches of acute myelogenous and lymphoblastic leukemia. DATA SOURCES: Professional journals, web sites, and books. CONCLUSION: The incidence of acute leukemia is increasing. As the population ages, it is anticipated that an even greater number will be diagnosed with this malignancy. The development of monoclonal antibodies, the recognition of the benefit of graft versus leukemia effect, and targeted therapies have improved overall survival rates. Still, age remains a significant prognostic variable. More research is needed to improve both the quality and the quantity of life for these patients. IMPLICATIONS FOR NURSING PRACTICE: Nurses must understand the rationale and implications of each phase of treatment to educate patients, administer treatments, manage side effects, and provide support throughout the continuum of care.
Adult↗
Overview of chemotherapy-induced diarrhea.
OBJECTIVES: To provide a general overview of chemotherapy-induced diarrhea (CID) that will highlight the pathophysiology, incidence, and impact of this problem, as well as describe the oncology nurse's role in the management of CID. DATA SOURCES: Primary and tertiary literature, the authors' clinical experience. CONCLUSION: CID is a frequent complication of many types of chemotherapy that can significantly affect patient quality of life, increase treatment costs, and limit the ability to deliver full doses of chemotherapy. Because patients may be reluctant to discuss diarrhea with their health care providers, vigilance on the part of the health care team is needed. IMPLICATIONS FOR NURSING PRACTICE: Through ongoing, regular patient contact, the oncology nurse is uniquely situated to monitor patients for the development of CID, assess its severity, and provide guidance to the health care team on the patient's status.
Antineoplastic Combined Chemotherapy Protocols↗