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Biomedical subjects

C d'Ivernois

Publications and source records attributed to C d'Ivernois.

13 recordsLinked to original sources
PubMed1994

Life-threatening pulmonary embolism with right-sided heart thrombus. Rapid recovery with recombinant tissue plasminogen activator.

We report the case of a woman treated with urokinase for acute pulmonary embolism with a right-sided heart thrombus. She developed life-threatening acute cor pulmonale which dramatically improved within 4 h with recombinant tissue plasminogen activator (rtPA). We emphasize the clinical interest of rtPA for the treatment of life-threatening pulmonary embolism.

Acute Disease↗
PubMed1992

Frequency of recurrent atrial fibrillation after catheter ablation of overt accessory pathways.

The effect of successful catheter ablation of overt accessory pathways on the incidence of atrial fibrillation (AF) was studied in 129 symptomatic patients with (n = 75) or without (n = 54) previous documented AF. Fourteen had had ventricular fibrillation. Factors predictive of recurrence were examined, including electrophysiologic parameters. Atrial vulnerability was defined as induction of sustained AF (greater than 1 minute) using single, then double, atrial extrastimuli at 2 basic pacing cycle lengths. When compared to patients with only reciprocating tachycardia, patients with clinical AF included more men (77 vs 54%, p = 0.008) and were older (35 +/- 12 vs 29 +/- 12 years, p = 0.01). They had a significantly shorter cycle length leading to anterograde accessory pathway block (252 +/- 42 vs 298 +/- 83 ms, p less than 0.001), greater incidences of atrial vulnerability (89 vs 24%, p less than 0.001) and subsequent need for cardioversion (51 vs 15%, p less than 0.001). After discharge, the follow-up period was 35 +/- 12 months (range 18 to 76); 7 patients with previous spontaneous AF (9%) had recurrence at a mean of 10 months after ablation. Age, presence of structural heart disease accessory pathway location, atrial refractory periods and accessory pathway anterograde conduction parameters were not predictive of AF recurrence. Persistence of atrial vulnerability after ablation was the only factor associated with further recurrence of AF. Atrial vulnerability was observed after ablation in only 56% of patients with previous AF versus 89% before ablation. It is concluded that successful catheter ablation of accessory pathways prevents further recurrence of AF in 91% of patients.(ABSTRACT TRUNCATED AT 250 WORDS)

Adolescent↗
PubMed1992

Elimination of atrioventricular nodal reentrant tachycardia using discrete slow potentials to guide application of radiofrequency energy.

BACKGROUND: Ablation of the slow pathway has been performed to eliminate atrioventricular (AV) nodal reentrant tachycardia (AVNRT) either by a surgical approach or by using radiofrequency catheter technique guided by retrograde slow pathway activation mapping. From previous experience of midseptal and posteroseptal mapping, we were aware of the existence of peculiar slow potentials in most humans. Postulating their role in AVNRT, we studied these potentials and the effects of radiofrequency energy. METHODS AND RESULTS: Sixty-four patients (mean age, 48 +/- 19 years) with the usual form of AVNRT were studied. Slow, low-amplitude potentials were recorded when using the anterograde AV conducting system. Slow potentials occupied all (giving a continuum of electrograms) or some of the time between the atrial and ventricular electrograms. Their most specific patterns were their progressive response to increasing atrial rates, which resulted in a dramatic decline in amplitude and slope, a corresponding increase in duration, and a separation from preceding atrial potentials until the disappearance of any consistent activity. Slow potentials were recorded along a vertical band at the mid or posterior part of the septum near the tricuspid annulus. Radiofrequency energy applied at the slow potential site resulted in interruption of induced tachycardia within a few seconds and rendered tachycardia noninducible in all patients. A median of two impulses was delivered to each patient. In 69% of patients, postablation atrial stimulation cannot achieve a long atrial-His interval, which previously was critical for tachycardia induction or maintenance. No patient had AVNRT over a follow-up period of 1-16 months, and all had preserved AV conduction. In all except two patients, the PR interval was unchanged. In 47 patients, long-term electrophysiological studies confirmed the efficacy of ablation and the nonreversibility of results by isoproterenol; however, echo beats remained inducible in 40% of patients. CONCLUSIONS: An area showing slow potentials is present at the perinodal region in humans. In patients with AVNRT, application of radiofrequency energy renders tachycardia noninducible through the preferential modification of the anterograde slow pathway. With present clinical methods, the exact origin and significance of these physiological potentials cannot be specified.

Cardiac Pacing, Artificial↗
PubMed1992

[Potential value of omega-3 polyunsaturated fatty acids in the prevention of atherosclerosis and cardiovascular diseases].

Several epidemiological studies have shown decreased cardiovascular mortality and a lower incidence of coronary artery disease in subjects with high dietary intakes of Omega-3 polyunsaturated fatty acids. It has since been shown that Omega-3 fatty acids have a number of beneficial effects in the prevention of atherosclerosis in man: reduction of blood pressure, modifications of lipoprotein metabolism, modifications of haemostasis (increased bleeding time and reduced platelet aggregation), decreased plasma fibrinogen, modifications of the metabolism of arachidonic acid and its derivatives (decreased thromboxane and leukotriene synthesis, increased prostacyclin synthesis). Therefore, Omega-3 polyunsaturated fatty acids have several beneficial effects on the presumed mechanisms of atherogenesis and/or its complications: they could represent an original and seductive solution to the problem of prevention of cardiovascular disease.

Arteriosclerosis↗
PubMed1991

[Cardiac lesions in AIDS].

The frequency of cardiac lesions in AIDS patients is diversely evaluated. At post-mortem examination macroscopic lesions are said to have been found in 20 percent of the patients, and microscopic lesions in 50 percent. In some clinical studies, up to 55 percent of the patients had echocardiographic abnormalities. All three cardiac wall layers may be involved. Cases of myopericardial Kaposi's sarcoma or non-Hodgkin's lymphoma have been described, together with infectious myocarditis or pericarditis, non-obstructive cardiomyopathy, aseptic fibrinous pericarditis, marantic endocarditis and other, less frequent lesions.

Acquired Immunodeficiency Syndrome↗
PubMed1991

Decreased incidence of infection after renal transplantation with the use of cyclosporine.

The incidence of infection within six months of cadaveric kidney transplantation was reviewed in 183 consecutive patients. Prior to June, 1985, 91 patients received azathioprine 2 mg/kg/day and prednisone 0.5 mg/kg/day; 63 patients (group A1) also received antilymphocyte globulin 15 mg/kg/day for the first ten days, whereas for the 28 other patients (group A2) antilymphocyte globulin had to be withdrawn before 72 hours because of general intolerance. The next 92 patients received cyclosporine 5-8 mg/kg/day and prednisone 0.25 mg/kg/day (group B). The three groups were similar for all studied parameters except for the number of patients with anti-HLA antibodies. At six months the mortality rate was not significantly different between the three groups. After six months the number of infections per patient was 1.47, 1.03 and 0.84 (p less than 0.01) in groups A1, A2 and B respectively; the percentage of patients developing one or more infections was 81, 58 and 57% (p less than 0.01); bacterial infections: 57, 50 and 34% (p less than 0.01); viral infections: 40, 14 and 10% (p less than 0.01); cytomegalovirus infections: 27, 11 and 4% (p less than 0.001). After adjustment with logistic regression upon factors which might facilitate infections, the results showed a significantly lower incidence of infection for the cyclosporine-treated group, especially for cytomegalovirus, as compared with the antilymphocyte globulin-treated group.

Adolescent↗
PubMed1990

[Interventional rhythmology].

Interventional cardiorhythmology was born with the invention of electrical catheter ablation of the common atrioventricular bundle of His as a palliative treatment of supraventricular arrhythmias refractory to medicinal treatment. This method is now used as a curative treatment. In Wolff-Parkinson-White syndrome, all accessory pathways, whatever their location, can be destroyed with a very high success rate (96 p. 100) and very low morbidity and mortality rates. Reentrant nodal tachycardias can also be treated by catheter ablation with, however, a low risk of atrioventricular block which, for the moment, limits its indications. In intractable ventricular tachycardias, its indications will certainly be extended and its efficacy will increase since numerous recent studies have identified a limited, slow-conduction area (arrhythmogenic substrate) as being the real target for ablation. Other sources of energy are also used for the same purposes, including radiofrequency currents with results that are promising but vary according to the type of arrhythmia treated. Thus, interventional cardiorhythmology is progressively replacing surgery.

Arrhythmias, Cardiac↗
PubMed1989

[The stunned myocardium. A new pathological entity].

A 70 years old woman presented with clinical, electrical and haemodynamic evidence of myocardial infarction. The course of the disease was unusual in that enzyme levels were not increased and the electrocardiogram and ventricular kinetics returned to normal 25 days after the infarction. This syndrome was typical of electrical and mechanical myocardial stunning. The physiopathological theories behind this post-ischaemic transient myocardial dysfunction syndrome and its practical consequences are presented.

Aged↗
PubMedDate not supplied

Scrub typhus: an imported Rickettsial disease.

A case of scrub typhus due to Rickettsia tsutsugamushi is reported. This imported rickettsial disease was contracted by a 30-year-old woman while traveling in Thailand, and was transmitted by an infected mite's bite. Diagnosis was confirmed by specific serology and resolution was obtained by tetracycline therapy. Current concepts of the disease are reviewed.

Adult↗