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Biomedical subjects

C Zimmer

Publications and source records attributed to C Zimmer.

At least 181 records · Page 10Linked to original sources
PubMed1974

CD studies on the conformation of some deoxyoligonucleotides containing adenine and thymine residues.

CD studies of the deoxyoligomer series d(pT)(n) and d(pA)(n) show increasing CD maxima for oligo (dT)'s with chain length variation from two to seven, while oligo (dA)'s exhibit a decreasing CD maximum. Concentrated solutions of NaClO(4) cause a decrease in the CD of longer oligo (dT)'s towards the CD of d(pT)(2) which is different from oligo dA's. Probably base-sugar interactions are important in the observed conformational effects. The chemically synthesized oligomers dpApApTpT and dpTpApTpA show deviations in their CD spectra which reflect a dominating conformational effect of d(pA)(2) in the former but not in the alternating isomer.

Adenine↗
PubMed1970

Optical rotatory dispersion properties of nucleic acid complexes with the oligopeptide antibiotics distamycin A and netropsin.

ORD measurements of nucleic acids in the presence of the oligopeptides netropsin and distamycin A have indicated association of the antibiotics with DNA and strong conformational changes of the DNA structure with specificity to AT-rich helical regions. The RNA conformation is relatively unaffected by these antibiotics. The results are explained in terms of a perturbation of the DNA secondary structure as well as of the chromophore system of the oligopeptides.

Journal Article↗