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Biomedical subjects

C Zhang

Publications and source records attributed to C Zhang.

At least 757 records · Page 42Linked to original sources
PubMed1989

Possible involvement of beta-endorphin in the deteriorating effect of arginine vasopressin on burn shock in rats.

The effect of intracerebroventricular injections of arginine vasopressin (AVP) on burn shock in the rat and its possible mechanism were explored in this study. AVP was administered intraventricularly at 30 min intervals (50 ng) in the burned rats. The arterial pressure and electrocardiogram (ECG) were recorded with a multipurpose polygraph before and after burn. Compared with the control, the MAP of the rats in the AVP group was elevated at the initial stage and fell dramatically at the late stage of burn shock with a higher mortality. The ECG of the rats in the AVP group also displayed earlier changes such as elevation of S-T segment, inversion of T wave, and ventricular fibrillation. These findings suggest an unfavorable role of AVP in burn shock. The plasma, hypothalamic, and anterior and posterior pituitary levels of beta-endorphin 3 hr after burn were measured by radioimmunoassay. The increased level of beta-endorphin in the plasma after AVP treatment indicates the possible involvement of beta-endorphin in the deteriorating effect of AVP on burn shock.

Animals↗
PubMed1989

[Preventive effects of fortified pollen on diphenylhydantoin teratogenesis].

This paper reports the preventive effects of fortified pollen and folic acid on diphenylhydantoin (DPH) teratogenesis in pregnant SD rats. The experiment showed that i.p. injection of DPH 75mg/kg per day to pregnant rats on gestational days 7 through 11, and feeding of fortified pollen (pollen 10g/kg per day plus folic acid 20mg/kg per day) or folic acid (20mg/kg per day) on gestational days 0 through 20 may partly prevent the embryotoxicity and fetal toxicity produced by DPH. However, the preventive effects of fortified pollen is better than those of folic acid on the following: decrease of fetal body weight; retarded ossification of metacarpus, proximal phalanx, metatarsus, and supraoccipital bone; sternebrae ossification agenesis; subcutaneous hemorrhage; single eye defect; hydronephrosis and the widening of subarachnoid space. This paper also discusses the possible mechanism of prevention of fortified pollen and folic acid against DPH teratogenesis.

Abnormalities, Drug-Induced↗
PubMed1989

[Influence of subtotal gastrectomy on bile acid concentration, total bacterial counts in the gastric juice, and histologic changes in the gastric mucosa].

The concentrations of bile acids, PH and total bacterial counts in the gastric juice were measured among 44 patients with peptic ulcer before and after subtotal gastrectomy (Billroth II in 14 cases, Billroth I in 10 cases, and PAFPG in 20 cases). Thirty three patients were studied by endoscopy and gastric mucosa biopsy one year after the surgery. The results showed that the fasting gastric bile acids concentrations in both B-II and B-I groups were significantly higher than in PAFPG group, when examined 3 weeks and 1 year postoperatively. The PH and total bacterial counts in gastric juice were increased significantly after B-II and B-I reconstruction compared with PAFPG. The abnormal histology of gastric remnant mucosa was more common in B-II or B-I groups than in PAFPG (P less than 0.05). Our data demonstrated that B-II and B-I gastrectomy caused considerably enterogastric reflux, while PAFPG prevented it effectively by keeping the gastric physiology in a relatively stable status. It is the authors' belief that the results provide objective basis for selecting surgical procedure and evaluating operative effects.

Adult↗
PubMed1986

[Reimplantation of 83 teeth].

A total of 83 teeth were reimplanted after extraction and treatment of periapical or pulpoperiodontal lesions in 79 patients, age range 9 to 55 years. Only anterior teeth were immobilized by ligature and self-polymerizable resin. Follow up of from 1 to 5 years showed complete success in 69% clinical success but with root lysis in 11%, as shown by radiologic imaging, and failure of treatment, mainly in patients over 40 years, in 20%. Healing was usually by ankylosis but an alveolodental new ligament formation was noted in only 3 cases. Root lysis occurred in 28% of cases, including 1/3 rd of the compensated type with a very slow course and 2/3 rds of the inflammatory type with resulting failure of treatment.

Adolescent↗