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Biomedical subjects

C Zeană

Publications and source records attributed to C Zeană.

26 records · Page 2Linked to original sources
PubMedDate not supplied

Morphophysiological studies in experimental myocardial aggressions with isoproterenol. Note I. Morphological aspects.

The morphopathogenesis of lesions induced by high doses of isoproterenol injected for 1-7 days and 1-3 months is dynamically studied in groups of Wistar rats and guinea pigs. The disseminated myocardial necroses induced were of a hypoxic nature. By cicatricial substitutions, lesions of cardiosclerosis similar to those observed in pheochromocytoma cases were obtained.

Animals↗
PubMedDate not supplied

Morphophysiological studies in experimental myocardial stress induced by isoproterenol. Note II. The myocardioprotector effect of magnesium ascorbate.

The efficiency of magnesium ascorbate, a new Romanian cardioprotector drug, was studied in guinea pigs and Wistar rats, both normal and with scurvy, within the framework of morphophysiological investigations of the pathogenesis of myocardial disease induced by large doses of beta-adrenergic substances of the isoproterenol type. The preventively treated animals presented only disseminated myocardial ultrastructural lesions within reversible limits. Biochemically, as compared with controls, a return to normal levels of ATP and Mg2+ and a decrease in the uptake of 45CaCl2 by the myocardium were observed. The pharmacological mechanisms of action of magnesium ascorbate are discussed.

Animals↗
PubMedDate not supplied

[Immunological aspects of adverse reactions during treatment with rifampicin].

It has already been established that during the treatment with rifampicin severe adverse reactions may occur, especially mediated by immune mechanisms. The most severe are those followed by renal failure. This type of reactions usually occur in patients that have undergone previous long treatments with the drug (RMP), given intermittently, twice a week, who, after an intermission, take up again the treatment with rifampicin. The symptoms occur after the administration of the first dose of the second course. Three cases are presented in the paper, of renal failure that developed after a new course of rifampicin was started. In spite of the treatment applied, which included hemodialysis, two of the patients died. In all three the indirect Coombs test was positive for anti -- RMP antibodies, and the histopathologic investigation revealed extensive lesions, including necrosis, of the renal tubules. Diagnostic, prognostic, pathogenic and therapeutic aspects of the cases are discussed.

Acute Kidney Injury↗
PubMedDate not supplied

[Surgically treated pulmonary transfixing wound penetrating the right ventricle. Autoimmune pericarditis. Recovery].

A clinical observation is presented, of patient with a transfixiant wound of the right lung that penetrated the right heart ventricle. Surgery was performed and the patient recovered without sequels. Comments are made in connection with the frequency of cardiac wounds, with the diagnosis and the emergency surgical treatment. The patient was followed clinically and para-clinically for a period of two years by functional explorations, electrocardiography, radiology and immunological methods. An auto-immune post-traumatic pericarditis ws noted in the evolution.

Adult↗