[Unusual aspects of acute coronary insufficiency].
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Aged↗
Biomedical subjects
C Zamfir
Publications and source records attributed to C Zamfir.
[Considerations on some aspects of acute disorders of cardiac rhythm].
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Adult↗
[Considerations on 2 cases of traumatic heart diseases].
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Adult↗
[A comparative study of the dimensional variability in different cell types of the human adrenal cortex in the newborn infant and the adult].
The selection of the material for this study was governed by the idea that at the newborn like at the adult, the cortex of the adrenal gland is complete, including all the three zones, while medulla is not structured until 12-36 month; for this reason, we used only the cellular cortical elements. The quantitative method of evaluation of the cellular diameter, as well as the interpreting and correlation of the values with age, have confirmed that the dynamics of the cellular components of the adrenal gland depends on age, indicating significant differences. The cell diameter is usually bigger at the newborn compared with the adult (with zonal variations). The variability is relatively small which means that the individual values are placed in a limited field.
Adrenal Cortex↗
[Changes in the histoarchitectonics and enzymatic histochemistry in guinea pigs during chemically induced stress].
The adrenal glands particularly react to various chemical over-requirements. Through the administration of aloxan to a group of thirteen guinea pigs we investigated the different implication of the major adrenal components (the cortex and the medulla), as well as the affecting of the enzymatic histochemistry. Aloxan acts as a toxic both at the nuclear level and on the cellular membranes which explains the modifications that occur especially at the level of the zona fasciculata. The enzymatic reactions were moderately positive even reduced here and there because aloxan is able to induce the variable levels of the enzymatic inhibition.
Adrenal Glands↗
[The middle cerebral artery system in fetuses: the distribution of the pial branches].
The aim of our study is to point out the influence of the cerebral development on the evolution of the middle cerebral artery (MCA) system. Brains of 20 fresh fetuses (16-22 weeks) were injected with gelatin-ink China mixture, observed and dissected under surgical microscope in correlation with the evolution of the sylvian fossa. Ending pattern of MCA and territories of distribution of its branches were also discussed.
Female↗
[Intermesenteric anastomoses].
This work is based on dissection and the analysis of the arteriographies of two mesenteric arteries and it analyses the type of intermesenteric anastomoses and their importance in surgical practice. The morphological varieties of Riolan's arcade depends on its pillars, as well as on the eventual presence, especially in the middle part of the transversal mesocolon, of the secondary arcades; it seems that the colic wall necrosis depends less upon the location of the lesion or the level of the suture of the arcade, but more so on the stretch of the destruction of the mesocolon. The intermesenteric trunk, a second way of intermesenteric anastomoses is a embryological remaining, non-functional in normal conditions, but capable to partially or completely replace the Riolan's arcade when the later is sutured or interrupted.
Angiography↗
Fine-needle biopsy cytology in autoimmune thyroiditis.
Fine-needle biopsy is used in the thyroid pathology especially for the differential diagnosis concerning malignant lesions. From a total of 59 cases of thyroiditis, in 12 was possible to proceed to fine-needle biopsy, in large goiters and nodules larger than 1 cm in diameter; in these cases were obtained smears, stained in May-Grünwald-Giemsa technique. In 9 cases of the 12 investigated, in the smears appeared lymphocytes and macrophages, cells commonly found in the infiltrates of the thyroid gland, in autoimmune thyroiditis, and sometimes also few normal thyrocytes. Fine-needle biopsy is important in the diagnosis algorithm of the thyroid nodules, involving 4, up to 7% of the general population. It has also the advantage of reducing the number of cases solved by surgical therapy, as it is the case with the diagnosis of Hashimoto's thyroiditis.
Biopsy, Needle↗
Assessing the plasma pharmacokinetics, tissue distribution, excretion and effects on cholesterol pharmacokinetics of a novel hydrophilic compound, FM-VP4, following administration to rats.
PURPOSE: The purpose of this project was to 1) assess the disposition kinetics of [3H]-cholesterol following co-administration with a novel hydrophilic compound, FM-VP4, and 2) determine the pharmacokinetics, tissue distribution and excretion of [3H]FM-VP4 following single oral (150 mg/kg which includes 100 mCi of radiolabel) and intravenous (15 mg/kg which includes 10 mCi of radiolabel) doses. METHODS: Following an overnight fast (12-16 h) and 48 h post-surgery, adult male Sprague Dawley rats were divided into six treatment groups (n=4/group). Groups received single oral doses of 25 mCi/ml [3H]cholesterol alone or with 5, 10, 20, 50 and 100 mg/kg FM-VP4 at 0700 h. Ten percent Intralipid was used to solubilize and co-administer [3H]-cholesterol and FM-VP4. LC-MS analysis confirmed minimal cholesterol and vegetable stanol content within 10% Intralipid. Thin layer chromatography was used to confirm that the majority of radioactivity measured in plasma was associated with either esterified or unesterified cholesterol. In a second study pharmacokinetics of [3H]FM-VP4 were studied following intravenous or orally gavaged doses (n=8). Tissues, urine and feces were also collected in FM-VP4 kinetics study to measure tissue distribution of radioactivity. Plasma [3H]-cholesterol and [3H]FM-VP4 were tested for radioactivity. RESULTS: FM-VP4 co-administration significantly decreased [3H]-cholesterol AUC0-48h and Cmax, and increased CL/F and Vd/F of [3H]-cholesterol as compared to controls in a dose-dependent manner. Following oral administration of [3H]FM-VP4, the majority of radioactivity following was recovered in the feces and gastrointestinal (GI) tract. The compound exhibited an oral bioavailability of 6.5%. Following IV administration, a two-compartment pharmacokinetic model was observed and the majority of the radioactivity was recovered in the GI tract. CONCLUSIONS: FM-VP4 reduces plasma concentration of [3H]-cholesterol in fasting rats. [3H]FM-VP4 has a very low oral bioavailability.
Administration, Oral↗
[The luteolytic action of prostaglandin F2-alpha analogues in guinea pig's ovary].
The role of prostaglandin at the level of the female genital system is multiple; they are involved in ovulation, luteolysis, contractility of the tube muscles, contraction of the gravid uterus, dilatation of the cervix. The synthetic analogous of the prostaglandin F2 alpha are utilized in a large area of treatments, for multiple purposes. The study was made on 2 lots with 10 non pregnant female guinea pig: the first lot was the witness lot and didn't receive any substance. The second lot received 100 micrograms/kg/day Isopropyl ester PGF2 alpha. The prostaglandin analogous produces vasodilating effects on the ovary blood vessels and luteolytic effects with the destruction of the ovarian follicles.
Animals↗
[Ultrastructural characteristics of the adrenal gland].
The Adrenal glands can be viewed as sustaining vital processes in the human body, through two different but related components: the cortex and the medulla. It is well known that the close connection between the cortical cells is able not only to support the adrenal functions, but in the same time to serve the better understanding of the normal way of its hormonal production. Using the ultrastructural study of the adrenal gland, we obtain images which can provide informations about details of the cellular structure, in the eventuality that all this work will continue to improve to the point that we might be able to completely understand the complex interrelations between the structure of each cell and the function of the whole organ.
Adrenal Glands↗