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Biomedical subjects

C Z Fuchs

Publications and source records attributed to C Z Fuchs.

7 recordsLinked to original sources
PubMed1982

A double-blind study of tranylcypromine treatment of major anergic depression.

Fifty-nine anergically depressed patients were randomly assigned to 6 weeks of double-blind treatment with either tranylcypromine or placebo. Anergic major depression most typically occurs in primary bipolar and in pseudounipolar affective illnesses. We hypothesized that tranylcypromine would be a highly effective and rapid treatment for depressions of this type. Results of repeated measures analyses of variance showed superiority of active drug over placebo by the end of the first week, and this improvement increased in significance at each successive visit. Improvement on tranylcypromine after week 1 was greater than that on placebo after week 6. Analysis of covariance of week 6 scores (corrected for week 0 scores) showed significantly greater improvement for tranylcypromine patients on all measures of depressive symptomatology. Tranylcypromine is a rapid, relatively safe, and dramatically effective treatment for anergic depression. Since 24 of 29 of the bipolar subjects had previously failed to respond to tricyclics and since bipolar depression is usually anergic, tranylcypromine should be compared to imipramine to determine the antidepressant of choice for manic-depressive illness.

Adult↗
PubMed1981

When a schizoaffective diagnosis has meaning.

Recently, there has been a flurry of studies showing that schizoaffective patients, diagnosed using acute symptom complexes, usually turn out to have affective disorders if they are rediagnosed applying more reliable longitudinal parameters. However, Occam's razor cuts both ways. This investigation shows that if schizoaffective illness is diagnosed using the nonacute parameter "presence of interepisodic thought disorder," it looks more like schizophrenia. Schizoaffectives diagnosed this way have earlier onset of illness, tend to remain unmarried, usually do not abuse alcohol or sedatives, have a worse response to psychopharmacological treatments, relapse more frequently, and tend to deteriorate.

Acute Disease↗
PubMed1980

Age, dementia, dyskinesias, and lithium response.

Nineteenth-century neuropsychiatrists felt that the aged bipolar patient usually developed chronic mania, which eventually turned into dementia. The authors' elderly patients seemed to experience few such denouements, so they evaluated the course and treatment response of 81 bipolar patients over the age of 55. Fifty-six responded well to lithium. Advanced age had no effect on course or outcome. However, with increased clinical evidence of neurological illness there was an increased incidence of chronic mania, a poorer response to lithium, and more frequent and severe neurotoxicity. Extrapyramidal syndromes were particularly devastating.

Age Factors↗
PubMed1980

Pseudomanic-depressive illness and cognitive-behavior therapy.

A history of manic or hypomanic symptoms is not pathognomonic of manic-depressive illness (MDI). The authors present a patient in whom manic symptoms probably did not represent MDI, but were part and parcel of a struggle to adapt to the omnipresent threat of death. During the course of brief cognitive-behavioral treatment, the patient experienced rapid and significant improvements without medication. He has remained symptom free since termination.

Achievement↗