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Biomedical subjects

C Young

Publications and source records attributed to C Young.

At least 271 records · Page 15Linked to original sources
PubMed1980

Selective vs. nonselective media and direct plating vs. enrichment technique in isolation of Vibrio cholerae: recommendations for clinical laboratories.

The occurrence of human cholera along the Gulf of Mexico and the isolation of Vibrio cholerae O1 from the Gulf and Chesapeake Bay make it imperative that microbiology laboratories along estuaries develop the capabilities to culture for these pathogens. In attempts to devise a simplified but efficient culture procedure, a selective medium, thiosulfate-citrate-bile salts-sucrose (TCBS) agar, was compared with a nonselective medium, gelatin agar (GA), and the utility of enrichment was examined. TCBS agar detected 99% of the stools found to be positive by all techniques combined, whereas GA identified only 80%. Of acute diarrheal stools, 96% were positive on direct plating, whereas only 66% of formed stools containing V. cholerae were detected by direct plating. Stools from patients with acute diarrhea can be plated directly into TCBS agar alone; stools from persons shedding low numbers of organisms (such as contacts, carriers, or patients receiving antibiotics) should be incubated first in an enrichment broth and then on TCBS agar.

Bacteriological Techniques↗
PubMed1980

Relationship between physiological and self-reported stressful response and psychosomatic disorders.

A revised version of the Atonomic Perception Questionnaire (Mandler, Mandler, & Uviller, 1958) was administered to 359 psychology students and the highest and lowest scoring (12.5%) males and females (N = 88) of this group were selected to participate in two experiments. In Exp. 1, skin conductance, muscle tension, respiratory rate, and heart rate were recorded prior to and during presentation of neutral and stressful visual stimuli. In Exp. 2, the same indices were recorded and the same procedure was used. Participants were instructed to rate physiological reactivity to the stimuli. Finally, a medical history questionnaire was mailed to each participant 1 wk. after completing the experiments. The data indicate that this version of the Autonomic Perception Questionnaire was predictive only of responsivity of skin conductance to stressful stimuli.

Arousal↗
PubMed1979

Metabolic changes during dopamine infusion in dogs.

The effects were investigated, in 12 dogs, of the infusion of dopamine 10 or 30 micrograms kg-1 min-1 on circulating glucose, glycerol, lactate and potassium concentrations. Both doses of dopamine produced in initial increase in blood glucose concentration (P less than 0.05) followed by hypoglycaemia (P less than 0.05). Lipolysis was stimulated as shown by an increase in plasma glycerol concentrations with dopamine 10 micrograms kg-1 min-1 (P less than 0.05) and dopamine 3 micrograms kg-1 min-1 (P less than 0.01). Blood lactate concentrations increased slightly in both groups, but this was significant (P less than 0.05) only in the dogs infused with dopamine 10 micrograms kg-1 min-1. Dopamine had no significant effect on the plasma potassium concentration.

Animals↗
PubMed1979

The inverse relationship between cost and survival in the critically ill cancer patient.

The enormous cost of intensive multiple organ system support is apparent from patient or third party charges of $1500--$2000 per day exclusive of physician fees sampled during a retrospective review of 700 consecutive recent admissions to the Critical Care Facility of Memorial Cancer Center. Mortality rates of 49% for general medical, 54% for lymphoma or leukemia, and 20% for surgery patients suggest the need for a selective admission and discharge policy which concentrates financial and personnel resources on those for whom there remains a reasonable chance of worthwhile palliation, if not cure, of their malignancy. An informal policy of this kind may have contributed to a 10% increase in hospital discharges and a reduction of in-unit mortality from 22--18% when compared to 1035 earlier unselected admissions. A modified version of the classification suggested by the Critical Care Committee of the Massachusetts General Hospital has been adopted for use at this institution. A similar approach by other cancer centers is urged so that predictive indices based on prognosis of the underlying disease as well as physiological status may be developed. Otherwise, cost-benefit analysis by third party payers or government will become an unavoidable, and less satisfactory, alternative.

Adult↗
PubMed1979

Phase II trial of pyrazofurin, alone and in combination with trifluorothymidine, in non-Hodgkin's lymphoma.

A phase II trial of pyrazofurin, alone and in combination with trifluorothymidine, was carried out in patients with advanced non-Hodgkin's lymphoma. None of the 19 patients evaluable for response had complete or partial remissions but 14 had minor regressions. Toxicity, consisting primarily of myelosuppression and stomatitis, was of moderate severity. These studies suggest that pyrazofurin, alone or in combination with trifluorothymidine, is of limited utility in advanced non-Hodgkin's lymphoma.

Antibiotics, Antineoplastic↗
PubMed1979

Phase I evaluation of piperazinedione in patients with advanced cancer.

The effects of iv administered piperazinedione were studied in 28 evaluable adult and eight evaluable pediatric patients with advanced cancer. Piperazinedione produced predictable myelosuppression of moderate degree at dosages of 3--3.5 mg/m2/day X 5 days by iv injection. When given in this manner, nausea and vomiting did not occur. Single iv doses of 10--15 mg/m2 produced mild-to-moderate nausea and vomiting and mild myelosuppression. Thrombocytopenia was more severe than leukopenia in both schedules. The drug produced comparable dose-related effects in adults and children. Although no therapeutic response was observed in the adults, a partial remission of 6 months' duration was seen in one child with Hodgkin's disease.

Adult↗
PubMed1978

Cardiorespiratory effects of increased airway pressure during controlled and spontaneous breathing after cardiac surgery.

The cardiorespiratory effects of intermittent positive pressure ventilation with zero end-expiratory pressure (IPPV), continuous positive airway pressure breathing (CPAP) and spontaneous breathing (SR) were studied in 11 patients 3--20 h after open-heart surgery. The transition from IPPV to CPAP resulted in a significant reduction in tidal volume and significant increases in respiratory frequency, PaCO2, oxygen transport and mean arterial pressure, but there were no significant changes in cardiac output or PaO2. There were no significant differences in any of the measurements between CPAP and SR.

Adult↗
PubMed1975

Effects of lowered environmental temperature on the growth of exoerythrocytic stages of Plasmodium berghei.

The effect of lowered host-environmental temperature upon the development and maturation of the preerythrocytic tissue stages of rodent malaria parasites has been investigated in two strains of Plasmodium berghei originating from the highlands of Katanga. Young albino rats inoculated with massive sporozoite doses of P. berghei NK 65 and maintained for 48 hours at 12 degrees C developed small, stunted tissue schizonts, averaging 11 X 15 microns, of a distinct morphology. Control rats kept at room temperature of 27 degrees C showed mature tissue schizonts of normal growth averaging 24 X 29 microns. Blood from the rats kept at lower temperature for 48 to 50 hours failed to produce parasitemia when inoculated into susceptible recipient mice. All the mice given blood from control rats developed parasitemia. However, when sporozite-inoculated rats were kept for 96 hours or longer at 12 degrees C they developed parasitemia and their liver showed maturation of 10% of the preerythrocytic schizonts. Experiments with the ANKA strain of P. berghei did not show significant differences in size and morphology between parasites in rats kept for 46.5 hours at 9 degrees C and 12 degrees C and those in controls kept at 20 degrees C. However, subinoculation of blood from the low temperature experimental groups into recipient mice at 46.5 hours after intravenous sporozoite inoculation failed to produce parasitemia, whereas all the recipient mice from the control groups developed parasitemia in 4 or 5 days. The findings are discussed in the light of the evolution of plasmodia and the phenomena of relapse and delayed primary attack in certain malaria infections.

Animals↗