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Biomedical subjects

C Y Chang

Publications and source records attributed to C Y Chang.

At least 253 records · Page 14Linked to original sources

Computed tomography of a meniscal cyst.

A meniscal cyst of the knee is a rare lesion, and a palpable large meniscal cyst is even more rare. This article suggests that CT scan demonstrates clear location, size, contents, and connection of the cyst with meniscus and peripheral tissue. By a combination of arthrography and CT scan, detection of the cysts in zone 3 (parameniscal area) is possible with ample demonstration of whether the cyst is associated with a meniscal tear. This provides a guideline in determining the treatment of the lesion.

Adult↗

Marrow culture studies in adult acute myeloid leukemia at diagnosis and during complete remission.

We used the human placental conditioned medium stimulated single layer agar culture technique to study the in vitro growth of marrow cells from 62 adult patients with acute myeloid leukemia (AML). Bone marrow cells were cultured from 50 patients at the time of initial diagnosis, 19 patients in early remission and 20 patients during their full complete remission. Marrow cultures from untreated patients exhibited heterogeneous growth patterns ranging from complete growth failure to excessive microcluster formation. We classified the growth patterns into 4 groups: (1) Gr I: normal growth, (2) Gr II: no growth, (3) Gr III: decreased growth, (4) Gr IV: excessive growth of microclusters. At presentation, none had Gr I growth; Gr II growth was observed in 23; Gr III in 14 and Gr IV in 13. A predominance of no growth were seen in M1 and M3 subtypes, while Gr IV growth was more commonly observed in M2 or M4 subtype. We were unable to correlate the culture findings with age or white cell count. The present results not only indicated that AML at diagnosis was characterized by abnormal granulopoiesis but also demonstrated that leukemic progenitor cells were heterogeneous with different capacities to express their proliferating potential in vitro. Except few with decreased growth, the growth characteristics generally returned to normal with successful remission induction. Both Gr II and Gr IV growth patterns were not observed either in early remission or during full complete remission.

Adolescent↗

Testicular gonadal stromal (Sertoli cell) tumor.

Eighty-one cases of testicular gonadal stromal tumor have been reported in the literature. An additional case is herein reported. The pathologic, immunohistologic, and histogenetic aspects are presented.

Carcinoembryonic Antigen↗

Renal artery aneurysms. Significance of macroaneurysms exclusive of dissections and fibrodysplastic mural dilations.

Seventy-two patients (39 females and 33 males), 9 to 84 years in age, exhibited a total of 94 renal artery macroaneurysms. Solitary aneurysms affected 53 patients, and multiple aneurysms occurred in 19 patients. Arteriosclerotic changes, observed in nearly 30% of aneurysms, were considered secondary rather than primary processes in most instances. Renal artery fibrodysplasia was an associated finding among 27 patients. In 57 hypertensive patients, evidence supportive of renal artery aneurysms contributing to elevated blood pressure was meager. Two patients experienced frank aneurysmal rupture. Covert rupture into renal veins occurred twice. Aneurysmectomy was performed on 31 occasions. Nephrectomy, partial as well as total, was performed 17 times. No operative mortality occurred. Potential for rupture and an association with functionally important renal artery stenoses support surgical intervention in selected patients with renal artery macroaneurysms.

Adolescent↗

Cutaneous everted nipple ureterostomy.

Normal dog ureter transplanted to the skin by the everted nipple ureterostomy technique was found to be far superior to the skin flap ureterostomy in nevovascularization and healing of the stoma. The results suggest a possibility of successful application in the human; recent clinical experience supports animal data.

Abscess↗