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Biomedical subjects

C Xie

Publications and source records attributed to C Xie.

106 records · Page 6Linked to original sources
PubMed1991

[Longitudinal changes of serum specific antibodies in Lewis rats immunized with IRBP].

The serum antibodies specific to either interphotoreceptor retinoid-binding protein (IRBP) or retinal S-antigen were longitudinally determined in Lewis rats immunized with 50 x 10(-6)g of IRBP emulsified with complete Freund's adjuvant. To our knowledge, it is the first time to purify IRBP and to address the experiment with IRBP in China. It was shown that the antibody specific to IRBP appeared on the 7th day, followed by a gradual increase, and reached its peak on the 26th day after immunization. No antibody specific to S-antigen was found. The relation between anti-IRBP antibody and experimental autoimmune uveoretinitis (EAU) which occurred in the increasing phase of the antibody suggests that the humoral immunity may be implicated in the pathogenesis of EAU.

Animals↗
PubMed1990

[Epidemiological survey on patients with advanced filariasis in Shandong Province with bancroftian filariasis basically eliminated].

This paper reports on the incidence of advanced filariasis after basic elimination of bancroftian filariasis since 1983 in Shandong Province. Investigation was carried out in a population of 166,776 between 1984 and 1988 in 252 villages of Teng Xian and other 5 counties/cities, the erstwhile highly endemic areas. A total of 1,038 filariasis patients were found with an average incidence of 0.6%. Among them, 383 were with elephantiasis, 357 with chyluria and 298 with hydrocele. 902 cases (86.9%) who suffered the disease before the elimination of filariasis and 136 cases (13.1%) after it, 125 (91.9%) being chyluria cases. The oldest of the 1,038 cases was 86 years of age and the youngest, 6 years of age. The course of duration as 8-74 years in elephantiasis cases, 82.8% of them (317 cases) had previously lymphangitis and/or lymphadenitis. In the past three years 16.4% (52 cases) suffered from prolonged or intermittent acute lymphangitis and/or lymphadenitis. The results of this survey indicated that, after the basic elimination of filariasis in Shandong Province together with thorough clearance of infection source, elephantiasis and hydrocele persisted while new cases of chyluria continued to develop. Therefore, in such areas more emphasis should be put on the treatment of clinical patients. New patients should be surveyed and old patients be treated actively so as to reach the goal of eradicating filariasis.

Adolescent↗
PubMed1990

[plants of Coptis from Tibet and Yunnan].

In this paper the relationship of Tibetan Huanglian and Yunnan Huanglian with Coptis teeta has been studied. The distribution and taxonomic features of Tibetan Huanglian are just the same as Coptis teeta, but quite different from Yunnan Huanglian. The results reveal that Tibetan Huanglian and Yunnan Huanglian are different in botanical origin.

China↗
PubMed1990

[Effects of danggui shaoyao powder on blood rheological indexes and prostaglandin F2 alpha in dysmenorrhea patients].

The results showed that several blood rheological indexes of dysmenorrhea patients were abnormal, the contents of plasma prostaglandin F2 alpha (PGF2 alpha) and menstrual blood PGF2 alpha of the patients were significantly higher than those of the normal women. The abnormal indexes were recovered to normal range after the patients had been treated with Danggui Shaoyao Powder for 3 months. Danggui Shaoyao Powder had better actions of improving the abnormal indexes than Tianqi Dysmenorrhea Capsule did.

Adult↗
PubMed1990

[Serum antibodies to bovine retinal S antigen in the patients with uveitis and healthy subjects].

The antibodies to bovine S-Ag in sera were determined by ELISA in 43 patients with acute or chronic, anterior or panuveitis and in 32 healthy persons as controls. The results showed that the antibodies titers to bovine S-Ag in the patients with panuveitis were not different from those in the controls (P greater than 0.05). However the antibody titers to bovine S-Ag in the patients with anterior uveitis were significantly lower than those in the controls (0.01 less than P less than 0.05). It is suggested that there are naturally occurring antibodies to S-Ag in health persons. The relationship between antibodies to S-Ag and uveitis is discussed. It is indicated that natural antibodies to S-Ag may play a protective role in the healthy subjects.

Adolescent↗
PubMed1990

[A new species of Curcuma (zingiberaceae) from Sichuan].

The rhizomes and roots of Curcuma are commonly used as Traditional Chinese Drugs. In this paper, a new species of Genus Curcuma from Sichuan, viz. Curcuma chuanyujin is reported, it is similar to C. aromatica, but differs from the dispersion of downs and the colour of bracts.

Medicine, Chinese Traditional↗
PubMed1989

[Epidemiological surveillance of filariasis after its being basically eradicated in Shandong Province].

This paper reports the results of epidemiological surveillance in areas where filariasis has been basically eradicated and control measures no longer adopted in Shandong Province. A 3-year longitudinal surveillance in 18 villages in 5 counties and a cross-sectional survey in 13 villages of 4 counties were carried out. The results showed that the average microfilaria rate was further reduced from 0.28% and 0.15% in 1980 to 0.19% and 0.05% in 1986, decreased by 32.1% and 66.7% respectively. 34.2% of the microfilaremic cases were found to be negative during the two-year follow-up. The positive rate of IFA and skin test was 34.2% and 38.6% respectively. In longitudinal surveillance. of the 240,992 Culex pipiens pallens dissected, 152(0.06%) were found to harbour different stages of larvae, among them, 5 were infective larvae from 4 vector mosquitoes. In cross-sectional survey, of the 3,875 Culex pipiens pallens dissected only 1 which had bitten immigrant from Zhejiang was found to contain one larvae at stage 1. No positive mosquito was found in the household of native villagers. No new infection was discovered at longitudinal and cross-sectional survey. The transmission of filariasis in these areas was interrupted. The results showed that in areas where filariasis has been basically eradicated, further control measures may not be instituted, but the management population movement and surveillance should be strengthened.

Animals↗
PubMedDate not supplied

Acrolein is increased in Alzheimer's disease brain and is toxic to primary hippocampal cultures.

Accumulating evidence implicates oxidative stress in the pathogenesis of several neurodegenerative diseases including Alzheimer's disease (AD). Increased lipid peroxidation, decreased levels of polyunsaturated fatty acids, and increased levels of 4-hydroxynonenal (HNE), F(2)-isoprostanes, and F(4)-neuroprostanes are present in the brain in AD. Acrolein, an alpha,beta-unsaturated aldehydic product of lipid peroxidation, is approximately 100 times more reactive than HNE and recently was demonstrated in neurofibrillary tangles in the brain in AD. In three brain regions of 10 AD patients compared with 8 age-matched control subjects, we found increased mean extractable acrolein, with the increases reaching statistical significance in the amygdala and hippocampus/parahippocampal gyrus. In hippocampal neuron cultures, acrolein was neurotoxic in a time- and concentration-dependent manner and more toxic than HNE at 5 microM concentrations of each. Acrolein exposure led to a significant concentration-dependent increase in intracellular calcium concentrations. Collectively, these data show that acrolein is increased in the brain in AD and demonstrate neurotoxicity mechanisms that might be important in the pathogenesis of neuron degeneration in AD.

Acrolein↗